1.
Interdiscip Sci
; 4(4): 268-72, 2012 Dec.
Article
in English
| MEDLINE
| ID: mdl-23354815
ABSTRACT
The anti inflammatory potential of the human and microbial biotransformed derivatives of berberine were determined by molecular docking. It was revealed that almost all derivatives formed as a result of biotransformation showed increase in phospholipase A(2) binding affinity compared to berberine. The newly introduced -OH group/groups establish stronger hydrogen bonding interactions and more number of van der Waals contacts with the protein. As phospholipase A(2) is a target of anti inflammatory drugs, it might be concluded that certain biotransformed derivatives of berberine could be better anti inflammatory agents compared to berberine.