Subject(s)
Antineoplastic Agents/therapeutic use , Lymphoma, Large B-Cell, Diffuse/therapy , Stem Cell Transplantation , Adult , Aged , Antibodies, Monoclonal, Murine-Derived/administration & dosage , Female , Humans , Lymphoma, Large B-Cell, Diffuse/drug therapy , Male , Middle Aged , Prognosis , Remission Induction , Retrospective Studies , Rituximab , Transplantation Conditioning , Transplantation, Autologous , Treatment OutcomeSubject(s)
Aminoglycosides/administration & dosage , Antibodies, Monoclonal/administration & dosage , Antineoplastic Agents/administration & dosage , Hematopoietic Stem Cell Mobilization , Leukemia, Promyelocytic, Acute/therapy , Peripheral Blood Stem Cell Transplantation , Transplantation Conditioning , Antibodies, Monoclonal, Humanized , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Female , Gemtuzumab , Humans , Middle Aged , Remission Induction , Transplantation, AutologousSubject(s)
Leukemia, T-Cell , Neoplasm Regression, Spontaneous , Pancytopenia , Aged , Aged, 80 and over , Female , HumansABSTRACT
We report a rare case of chronic neutrophilic leukemia (CNL) which terminated in acute myeloblastic transformation 3 years after the onset of the disease. The increased leukocytes were mainly neutrophils at various maturational stages until 1 month before transformation without dysplastic hematopoietic cells or other myeloproliferative disorders. Repeated analyses for the Philadelphia chromosome (Ph1), rearrangement of the BCR gene or chimeric BCR/ABL mRNA, major, minor and mu, were negative. Genomic analysis of granulocyte colony-stimulating factor (G-CSF) receptor did not reveal any abnormality. The clinical manifestations were characterized by hyperleukocyte syndrome with respiratory distress and ischemic legs with gangrene.
Subject(s)
Blast Crisis/pathology , Bone Marrow/pathology , Leukemia, Neutrophilic, Chronic/pathology , Aged , Blast Crisis/genetics , Cell Transformation, Neoplastic , Fusion Proteins, bcr-abl/genetics , Gene Rearrangement , Humans , Leukemia, Neutrophilic, Chronic/genetics , Male , Philadelphia Chromosome , RNA, Messenger/genetics , Receptors, Granulocyte Colony-Stimulating Factor/geneticsABSTRACT
A patient with acute myeloid leukemia (AML)-M2 with t(8;21)(q22;q22) achieved complete remission with remission-induction chemotherapy followed by consolidation and intensification chemotherapies. T(8;21)(q22;q22) disappeared, but chimeric AML1/MTG8 was continuously detected in bone marrow cells. Following the development of therapy-related leukemia after 1 year, evolution of therapy-related AML-M4 with t(11;17)(q23;q25) and the rearrangement of the MLL gene were observed, while AML/MTG8 disappeared. After reinduction and following intermittent chemotherapies, a subsequent alternative transformation to AML-M2 occurred after detection of t(3;21)(q21;q22), with a break in the AML1 gene shown by interphase fluorescence in situ hybridization analysis. This leukemia transformed to AML-M4 after t(9;22)(q34;q11), with a minor BCR/ABL rearrangement, and then finally to AML-M2. This therapy-related leukemia was resistant to chemotherapy. These findings indicate that alterations in cytogenetic and molecular events caused by chemotherapeutic agents contribute to the sequential evolution of new leukemic clones with different morphology.
Subject(s)
Chromosomes, Human, Pair 21 , Chromosomes, Human, Pair 8 , Leukemia, Myeloid, Acute/genetics , Neoplasms, Second Primary/genetics , Translocation, Genetic , Adult , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Clone Cells/pathology , Cytogenetics , Evolution, Molecular , Fusion Proteins, bcr-abl/genetics , Humans , Leukemia, Myelomonocytic, Acute/genetics , Male , Neoplasms, Second Primary/chemically induced , Neoplasms, Second Primary/pathology , Translocation, Genetic/drug effectsABSTRACT
Two cases of non-Hodgkin's lymphoma (NHL) generated within 6 months in first degree relatives, a father and a son, are presented. The NHL was a diffuse large B-cell type in the father and a small cleaved follicular type in the son. Cytogenetic and molecular studies of the lymphoma cells revealed the rearrangement of the immunoglobulin heavy chain (JH) gene in both patients, the mutation of p53 gene in the father and t(14; 18) (q32; q21) in the son. Both patients had low serum immunoglobulin levels. It is not known whether the occurrence of NHL in this family was incidental or pathogenetically related, since there was no clear common molecular abnormality between the father and the son. The pathogenetic mechanism of this familial occurrence of NHL is discussed.
Subject(s)
Lymphoma, Non-Hodgkin/genetics , Adult , Aged , Family Health , Genes, p53/genetics , Humans , Immunoglobulin Heavy Chains/genetics , Lymphoma, Non-Hodgkin/etiology , Male , Mutation , PedigreeSubject(s)
Frameshift Mutation , Gene Deletion , Protein C/genetics , Thrombosis/genetics , Venous Thrombosis/genetics , Female , Humans , Middle Aged , PedigreeABSTRACT
A man with refractory anemia and trisomy 8 complained of repeated febrile episodes. He exhibited oral aphtha, exanthema, genital ulcer, and epididymitis. Laboratory data obtained during febrile episodes revealed leukocytosis with elevated CRP and ESR. Repeated examinations for infectious bacterial agents were negative. HLA analysis detected HLA-B51. Behçet's disease of incomplete type was diagnosed and successfully treated with prednisolone. It was speculated that the repeated febrile episodes may have been a manifestation of neutrophil hyper-function induced by increased blood levels of inflammatory cytokines, including IL-6, IL-8 and G-CSF, in association with rare complications of Behçet's disease.
Subject(s)
Anemia, Refractory/complications , Behcet Syndrome/complications , Chromosomes, Human, Pair 8 , Cytokines/blood , Trisomy , Anti-Inflammatory Agents/therapeutic use , Behcet Syndrome/drug therapy , Biomarkers/blood , Fever/etiology , HLA-B Antigens/blood , HLA-B51 Antigen , Humans , Male , Middle Aged , Myelodysplastic Syndromes/complications , Neutrophils/physiology , Prednisolone/therapeutic use , Recurrence , Treatment OutcomeSubject(s)
Anemia, Aplastic/immunology , Leukocytes, Mononuclear/immunology , Membrane Glycoproteins/blood , Myelodysplastic Syndromes/immunology , Anemia, Aplastic/blood , Anemia, Refractory/blood , Anemia, Refractory/immunology , Anemia, Refractory, with Excess of Blasts/blood , Anemia, Refractory, with Excess of Blasts/immunology , Antigens, Surface/blood , Fas Ligand Protein , Humans , Myelodysplastic Syndromes/blood , Reference ValuesABSTRACT
The quality of the sacred "temizu" water in shrines in Kyoto was surveyed. It was found that the sources of "temizu" were the municipal water supply or domestic wells and that the "temizu" was usually used for washing the hands and mouth, while in certain shrines it was drunk as well. Of 50 visitors responding to questions, 26 persons said that they drank "temizu". In some shrines using the municipal water supply as "temizu", the free residual chlorine concentration was lower than that in the municipal water supply itself. Contamination of "temizu" by Escherichia coli or Aeromonas hydrophila was observed in some shrines.
