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1.
Prenat Diagn ; 31(10): 985-9, 2011 Oct.
Article in English | MEDLINE | ID: mdl-21812008

ABSTRACT

OBJECTIVE: To compare the uptake of Down syndrome screening by women following referral by direct access and general practitioner (GP) modes. METHODS: The method of referral by either GP or direct access, for women who booked into prenatal care in Hull and East Yorkshire in 2010, was analysed using data collected from the Protos database at the Women and Children's Hospital, Hull. Subsequently, the uptake of first and second trimester screening for Down syndrome was reviewed by combining the Protos database to the screening data collected by the Clinical Biochemistry Laboratory at Hull Royal Infirmary, Hull. RESULTS: Women booked into prenatal care significantly earlier when referred by GP in comparison to direct access with a significant difference in screening uptake of 49.5 and 42.7%, respectively. The ratio of uptake between first and second trimester screening was not significantly different. CONCLUSIONS: Further research on the new direct access method of referral is required, as it may have a role in the uptake of prenatal screening for Down syndrome. More time is needed to show a definitive effect.


Subject(s)
Down Syndrome/diagnosis , Mass Screening/statistics & numerical data , Nurse Midwives , Prenatal Care/methods , Adult , Biomarkers/blood , Chorionic Gonadotropin, beta Subunit, Human/blood , Down Syndrome/blood , Female , General Practitioners , Humans , Mass Screening/methods , Medical Audit , Nuchal Translucency Measurement , Pregnancy , Pregnancy Trimester, First/blood , Pregnancy Trimester, Second/blood , Referral and Consultation , Retrospective Studies , alpha-Fetoproteins/metabolism
2.
Eur J Obstet Gynecol Reprod Biol ; 159(1): 95-8, 2011 Nov.
Article in English | MEDLINE | ID: mdl-21839574

ABSTRACT

OBJECTIVE: To describe any trends in the uptake of antenatal screening for Down's syndrome since the addition of the earlier first trimester combined test. STUDY DESIGN: All antenatal screening tests for Down's syndrome were carried out and their results were recorded by the Clinical Biochemistry Department at the Hull Royal Infirmary (HRI) and reviewed against the antenatal booking data held at the Women and Children's Hospital at HRI. The uptake of antenatal Down's syndrome screening for 5 different age groups of women across a four-year-period from 2007 to 2010 was analysed. RESULTS: There was a significant increase in uptake of antenatal screening for Down's syndrome from 43.9% to 56.5% after the introduction of the combined test in 2010. This increase was apparent in all age groups. There was no change in the proportion of women opting for an invasive test following a positive screening test. CONCLUSION: Addition of the earlier first trimester combined test has increased uptake of antenatal screening for Down's syndrome in women of all ages. This is most likely due to the advantages this test gives women such as earlier decision making, earlier further invasive diagnostic testing and earlier termination, if necessary.


Subject(s)
Down Syndrome/diagnosis , Patient Acceptance of Health Care , Prenatal Diagnosis/methods , Adolescent , Adult , Age Factors , Biomarkers/blood , Chorionic Gonadotropin, beta Subunit, Human/blood , Databases, Factual , Down Syndrome/diagnostic imaging , Down Syndrome/embryology , Female , Humans , Middle Aged , Nuchal Translucency Measurement , Pregnancy , Pregnancy Trimester, First/blood , Pregnancy-Associated Plasma Protein-A/analysis , Prenatal Diagnosis/psychology , United Kingdom , Young Adult
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