ABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Kartagener Syndrome/complications , Kartagener Syndrome/diagnosis , Delayed Diagnosis/prevention & control , Delayed Diagnosis/trends , Oxygen Inhalation Therapy , Radiography, Thoracic , Echocardiography/methods , Echocardiography , Kartagener Syndrome/physiopathology , Kartagener Syndrome , Oxygen Inhalation Therapy/instrumentationSubject(s)
Colon , Foreign Bodies/complications , Liver Abscess, Pyogenic/etiology , Aged, 80 and over , Humans , MaleABSTRACT
OBJECTIVE: To analyze the incidence of adverse drug events (ADE) as noted in hospital discharge reports, as well as their potential avoidability, drugs involved, clinical symptoms and the type of medication errors that led to the preventable ADE. MATERIAL AND METHODS: A retrospective study for the January- December 2005 period of time, at a district hospital. ADE were detected in which patients with discharge reports including event codes as defined by the IDC-9-CM system, using the minimum basic data set (MBDS). RESULTS: ADEs were detected in 4.01% of all discharge reports in the study period (n = 160). 45% of ADEs were were detected at the Emergency Department (n = 72) and 55% (n = 88) were detected during hospitalization.62.3% of ADEs were considered potentially avoidable (n = 109). 38.1% of ADEs were serious, 40.0% moderate and 21.9% mild. Drugs most commonly involved in the ADEs sample studied included: antimicrobials (24.0%), systemic corticoids (15.4%), NSAIDs (11.4%), diuretics (10.3%), digoxin (9.1%), insulin and oral hypoglycaemic agents (5.7%), anticoagulants and heparin (5.7%). Inadequate therapy monitoring (47.7%), excessive dosage (28.5%), drug-drug interactions (10.1%) were the most common identified type of errors leading to preventable ADE. CONCLUSIONS: 3.2% of admissions was caused by ADEs. 2.2% of hospitalized patients experienced ADEs. 62% of ADEs were potentially preventable. A high proportion of preventable ADEs were around a small number of drugs. Effective safety practices directed to reduce the incidence of medication errors are needed.
Subject(s)
Adverse Drug Reaction Reporting Systems , Adult , Aged , Female , Humans , Male , Middle Aged , Retrospective Studies , SpainABSTRACT
Objetivo: Analizar la incidencia de los acontecimientos adversos a medicamentos (AAM) notificados en el informe de alta hospitalaria, valorar su evitabilidad y describir los fármacos implicados, las manifestaciones clínicas y los tipos de errores asociados a los AAM prevenibles. Material y método: Estudio retrospectivo del Conjunto Mínimo Básico de Datos (CMBD) del periodo enero-diciembre de 2005 en todos los servicios asistenciales de un hospital de ámbito comarcal, centrado en los pacientes en cuyo informe de alta se incluían los códigos asociados a efectos adversos por medicamentos según la Clasificación Internacional de Enfermedades (CIE-9-MC) Resultados: Se detectan AAM en un 4,01% de las altas codificadas en el período de estudio (n = 160). 45% de los AAM (n = 72) causados por el uso extrahospitalario de fármacos y 55% (n = 88) durante la hospitalización. El 62,3% de los AAM eran prevenibles (n = 109). El 38,1% de los AAM fueron graves, 40,0% moderados y 21,9% leves. Los fármacos más frecuentemente implicados en AAM fueron: antiinfecciosos 24,0%, glucocorticoides sistémicos 15,4%, AINEs y otros analgésicos 11,4%, diuréticos 10,3%, digoxina 9,1%, insulina y antidiabéticos orales 5,7%, anticoagulante orales y heparina 5,7%. Las causas que motivaban su aparición fueron la falta de seguimiento (47,7%), dosis elevada (28,5%), e interacción medicamentosa (10,1%) Conclusiones: Un 3,2% de los ingresos urgentes estaba motivado por AAM. Un 2,2% de los pacientes hospitalizados presentó AAM. Un 62% de AAM era prevenible. Un alto grado de AAM prevenibles se centran en un número reducido de fármacos. Es necesario implantar prácticas efectivas de seguridad para reducir los errores de medicación
Objective: To analyze the incidence of adverse drug events (ADE) as noted in hospital discharge reports, as well as their potential avoidability, drugs involved, clinical symptoms and the type of medication errors that led to the preventable ADE. Material and methods: A retrospective study for the January- December 2005 period of time, at a district hospital. ADE were detected in which patients with discharge reports including event codes as defined by the IDC-9-CM system, using the minimum basic data set (MBDS). Results: ADEs were detected in 4.01% of all discharge reports in the study period (n = 160). 45% of ADEs were were detected at the Emergency Department (n = 72) and 55% (n = 88) were detected during hospitalization. 62.3% of ADEs were considered potentially avoidable (n = 109). 38.1% of ADEs were serious, 40.0% moderate and 21.9% mild. Drugs most commonly involved in the ADEs sample studied included: antimicrobials (24.0%), systemic corticoids (15.4%), NSAIDs (11.4%), diuretics (10.3%), digoxin (9.1%), insulin and oral hypoglycaemic agents (5.7%), anticoagulants and heparin (5.7%). Inadequate therapy monitoring (47.7%), excessive dosage (28.5%), drug-drug interactions (10.1%) were the most common identified type of errors leading to preventable ADE. Conclusions: 3.2% of admissions was caused by ADEs. 2.2% of hospitalized patients experienced ADEs. 62% of ADEs were potentially preventable. A high proportion of preventable ADEs were around a small number of drugs. Effective safety practices directed to reduce the incidence of medication errors are needed
Subject(s)
Humans , Adverse Drug Reaction Reporting Systems/statistics & numerical data , Medication Errors/statistics & numerical data , Pharmaceutical Preparations/adverse effects , Drug Utilization/statistics & numerical data , Retrospective Studies , Hospitalization/statistics & numerical data , Safety Management/organization & administrationABSTRACT
La prevalencia del hiperaldosteronismo primario ha aumentado significativamente, por lo que algunos autores lo consideran la causa principal de hipertensión arterial secundaria. Este hecho se basa en la gran frecuencia con que se detectan cocientes elevados de aldosterona/renina en pacientes hipertensos. Presentamos dos casos de hiperaldosteronismo primario por adenoma suprarrenal y revisamos el protocolo de estudio escalonado de los pacientes con dicha patología. El tratamiento farmacológico de los adenomas productores de aldosterona es una opción válida para el control de la presión arterial y la hipopotasemia, cuando no pueden intervenirse quirúrgicamente
The prevalence of primary aldosteronism has increased significantly so that some authors consider it as the main cause of secondary hypertension. This fact is based on the great frequency with which high aldosterone/renin ratios are detected in hypertensive patients. We present two cases of primary aldosteronism due to adrenal adenoma and review the protocol for stepwise investigation in patients with such a condition. Drug management of aldosterone-producing adenomas is an adequate option for controlling blood pressure and hypopotassemia when adrenalectomy is not viable
Subject(s)
Humans , Female , Adult , Hypokalemia/etiology , Hypertension/etiology , Hyperaldosteronism/complications , Adrenal Gland Neoplasms/complications , Adenoma/complicationsABSTRACT
No disponible
Subject(s)
Middle Aged , Humans , Behcet Syndrome/diagnosis , Cartilage Diseases/complications , Scleritis/complications , Stomatitis, Aphthous/complicationsSubject(s)
Adrenal Gland Neoplasms/complications , Diabetes Mellitus, Type 2/complications , Hyperglycemia/etiology , Leukocytosis/etiology , Pheochromocytoma/complications , Adrenal Gland Neoplasms/diagnosis , Adrenal Gland Neoplasms/surgery , Adult , Diabetes Mellitus, Type 2/blood , Diabetes Mellitus, Type 2/drug therapy , Endocrine Surgical Procedures , Female , Humans , Hyperglycemia/diagnosis , Hyperglycemia/drug therapy , Leukocyte Count , Leukocytosis/diagnosis , Leukocytosis/drug therapy , Magnetic Resonance Imaging , Pheochromocytoma/diagnosis , Pheochromocytoma/surgery , Treatment OutcomeABSTRACT
No disponible
Subject(s)
Male , Aged , Humans , Anti-Bacterial Agents/adverse effects , Ofloxacin/adverse effects , Achilles Tendon , Tendinopathy/chemically inducedSubject(s)
Edema/pathology , Physical Exertion , Skin Diseases/pathology , Skin/pathology , Adult , Biopsy , Diagnosis, Differential , Edema/etiology , Eosinophilia/etiology , Eosinophilia/pathology , Fasciitis/etiology , Fasciitis/pathology , Humans , Male , Middle Aged , Sclerosis/etiology , Sclerosis/pathology , Skin Diseases/etiologySubject(s)
Liver Abscess/microbiology , Yersinia Infections/microbiology , Yersinia enterocolitica , Humans , Male , Middle AgedABSTRACT
We present the case of a patient with AIDS who developed abscessified pneumonia by Rhodococcus equi. We publish this case given the rare frequency of presentation of this opportunistic infection in this type of patient and given its good clinical evolution, on the contrary of other cases described so far in the literature. The good evolution of the patient may be due to an early diagnosis, less than one month, and the combined medical therapy with rifampicine and tetracyclines.