The association between postprandial urinary C-peptide creatinine ratio and the treatment response to liraglutide: a multi-centre observational study.

AIMS: The response to glucagon-like peptide 1 receptor agonist treatment may be influenced by endogenous ß-cell function. We investigated whether urinary C-peptide creatinine ratio assessed before or during liraglutide treatment was associated with treatment response. METHODS: A single, outpatient urine sample for urinary C-peptide creatinine ratio was collected 2 h after the largest meal of the day among two separate groups: (1) subjects initiating liraglutide (0.6 â†’ 1.2 mg daily) or (2) subjects already treated with liraglutide for 20-32 weeks. The associations between pretreatment and on-treatment urinary C-peptide creatinine ratio and HbA1c change at 32 weeks were assessed using univariate and multivariate analyses (the ratio was logarithm transformed for multivariate analyses). Changes in HbA1c according to pretreatment urinary C-peptide creatinine ratio quartiles are shown. RESULTS: One hundred and sixteen subjects (70 pretreatment, 46 on treatment) with Type 2 diabetes from 10 diabetes centres were studied. In univariate analyses, neither pretreatment nor on-treatment urinary C-peptide creatinine ratio correlated with HbA1c change (Spearman rank correlation coefficient, r = -0.17, P = 0.17 and r = -0.20, P = 0.19, respectively). In multi-linear regression analyses, entering baseline HbA1c and log urinary C-peptide creatinine ratio, pretreatment and on-treatment log urinary C-peptide creatinine ratio became significantly associated with HbA1c change (P = 0.048 and P = 0.040, respectively). Mean (sd) HbA1c changes from baseline in quartiles 1 to 4 of pretreatment urinary C-peptide creatinine ratio were -3 ± 17 mmol/mol (-0.3 ± 1.6%) (P = 0.52), -12 ± 15 mmol/mol (-1.1 ± 1.4%) (P = 0.003), -11 ± 13 mmol/mol (-1.0 ± 1.2%) (P = 0.002) and -12±17 mmol/mol (-1.1±1.6%) (P=0.016), respectively. CONCLUSIONS: Postprandial urinary C-peptide creatinine ratios before and during liraglutide treatment were weakly associated with the glycaemic response to treatment. Low pretreatment urinary C-peptide creatinine ratio may be more useful than higher values by predicting poorer glycaemic response.

Prevalence of mesiodens among six- to seventeen-year-old school going children of Indore.

INTRODUCTION: 'Mesiodens' are the supernumerary teeth present in the midline of the maxilla between the two central incisors. These mesiodens are the most common supernumerary teeth and are usually responsible for eruption disturbance or delay of the maxillary anterior permanent teeth. The present study seeks to investigate the prevalence of mesiodens among school going children in Indore City, India. MATERIALS AND METHODS: The study was a retrospective collection of data to evaluate the prevalence of mesiodens among 3896 children, whose ages ranged between six and seventeen years. RESULTS: The results showed that males were affected approximately 1.2 times as frequently as females; 3.18% of the total screened population had mesiodens and among the affected population 4.03% had two or more mesiodens. Most of the mesiodens were conical in shape. The age, sex distribution, number of mesiodens per patient, shape, and direction of the eruption are presented in this study. CONCLUSIONS: The present study gives an insight into the prevalence of mesiodens among school going children of Indore city. A coincidental finding in our study has been the high risk of trauma associated with the occurence of mesiodens. This finding makes it mandatory to include mesiodens as a risk factor in traumatic dental injuries. Early diagnosis and management of these otherwise considered mild factors must be made mandatory in pediatric dentistry.