The role of delay in vaccination rate on Covid-19.

The role of vaccination in tackling Covid-19 and the potential consequences of a time delay in vaccination rate are discussed. This study presents a mathematical model that incorporates the rate of vaccination and parameters related to the presence and absence of time delay in the context of Covid-19. We conducted a study on the global dynamics of a Covid-19 outbreak model, which incorporates a vaccinated population and a time delay parameter. Our findings demonstrate the global stability of these models. Our observation indicates that lower vaccination rates are associated with an increase in the overall number of infected individuals. The stability of the corresponding time delay model is determined by the value of the time delay parameter. If the time delay parameter is less than the critical value at which the Hopf bifurcation occurs, the model is stable. The results are supported by numerical illustrations that have epidemiological relevance.

Photonic-crystal-based high-performance ring resonator using a topological interface state: design and analysis.

We propose a photonic crystal ring resonator for the enhancement of quality factor that supports two-dimensionally bounded topological edge states. Crystal parameters are obtained through finite-difference time-domain numerical simulation to get the enhanced quality factor using the topological properties of the photonic crystal. Topological edge states are created when two regions with dissimilar band topologies come together at an interface and are contained within a slab of dielectric material. These edge states can move along sharp edges without backscattering. The transmission dropout issue arises whenever the quality factor is enhanced in a conventional photonic system and is eliminated remarkably by employing the present approach. Such nanoscale photonic crystal structures promote robust interactions between quantum emitters and photonic edge states.

Transfer matrix optimization of a one-dimensional photonic crystal cavity for enhanced absorption of monolayer graphene.

The optical absorption enhancement of graphene is of significant interest due to its remarkable applications in optical devices. One of the most useful methods is placing graphene in an asymmetric Fabry-Perot cavity made of one-dimensional dielectric multilayers forming two mirrors. In that regard, using the transfer matrix method, we have explicitly calculated the required periodicity of the front photonic multilayer mirror to maximize the absorption in the graphene for any given combination of material types and number of layers. Then we studied the equivalence between these structural configurations and those with arbitrary periodicity but with defects, where the equivalence holds when ω=ξω0,ξ∈Z≥0. These defects are introduced via layer position alterations, based on which we propose an optimization algorithm to maximize absorption in structures having a cavity with an arbitrary periodicity. Numerical calculations are given for dielectric material combinations of TiO2/SiO2 and Ta2O5/SiO2, and to understand the behavior of these optimized structures for any general combination of material types, the mapping of their calculated front mirror periodicity for a range of refractive indices of the two material types has been studied.

Tunable terahertz absorption in Si/SiO2-graphene multilayers: disorder and magneto-optical effects.

In this work we theoretically investigate the influence of disorder and external perpendicular magnetic field on terahertz (THz) absorption in graphene/SiC cap layers on top of one-dimensional photonic structures. We show that left-handed circularly polarized light absorption can be achieved up to 0.9 and even nearly perfect absorption at magnetic fields over 4 T. It is also demonstrated that multichannel absorption can be obtained, in a broad frequency range, by increasing the disorder strength in the layer thicknesses, outperforming the corresponding periodic structures. Altogether, our results reveal the potentialities of introducing disorder to not only enhance but also to tune absorption in photonic superlattices with graphene under the influence of an external magnetic field, allowing for applications such as THz circular polarization selective sensors and photodetectors.

Study of the KIR gene profiles and analysis of the phylogenetic relationships of Rajbanshi population of West Bengal, India.

The natural killer (NK) cells have distinct receptors called killer cell immunoglobulin-like receptors (KIR) which are responsible for regulating NK cell responses to infections and malignancy. The extensive variations in the number and type of KIR genes can be used as a tool to understand the differentiation of populations and also for tracing genetic background. In this study, we have aimed to analyze the KIR gene polymorphism in the Rajbanshi population of West Bengal, India. To our knowledge this is the first report on the KIR gene polymorphism in the Rajbanshis, a population widely distributed in the Terai and Dooars region of West Bengal, India. Herein, we have studied the gene distribution of 14 KIR genes (KIR3DL1-3DL3, KIR 2DL1-2DL5, 2DS1-2DS5 and 3DS1) and two pseudogenes (KIR3DP1 and 2DP1). The gene frequencies and genotypic frequencies were calculated, based on which statistical analyses were performed. The presence of a considerable number of genotypic profiles suggests substantial diversity in the KIR gene pool of the Rajbanshis in the region studied. Apart from the framework genes (KIR2DL4, 3DL2, 3DL3 and 3DP1) present in all the individuals, the gene frequencies of other KIR genes varied between 0.84 and 0.15. Moreover the KIR polymorphisms of the Rajbanshis were also compared with that of available published data of the populations of other ethnicities. Though the Rajbanshi population showed a tendency to cluster with other Indian population based on KIR gene frequencies, the influence of Tibeto-Burman Lineage on their KIR genotypic profiles cannot be overlooked. Furthermore, evidences from previously published data on Y chromosome haplogroup diversity study on Rajbanshis support the view. Our results will not only help to understand the genetic background of the Rajbanshi population, but also in tracing the population migration events in the North-Eastern part of India and in illustrating the extensive genetic admixture amongst the different linguistic groups of the country and also in KIR-related disease researches.

Study of HLA Class I gene in Indian schizophrenic patients of Siliguri, West Bengal.

The authors studied the prevalence of the human leukocyte antigen (HLA) Class I gene in 136 (85 male, 51 female) India-born schizophrenia patients residing in and around the Siliguri subdivision of West Bengal by the PCR-SSP method. The control group consisted of 150 age- and sex-matched healthy individuals from the same ethnic group as the patients. Increased frequency of HLA A*03 as well as decreased frequencies of HLA A*31 and HLA B*51, was noted. The study suggests the possible existence of a susceptibility locus for schizophrenia within the HLA region.

Effect of copper-hydroquinone complex on oxidative stress-related parameters in human erythrocytes (in vitro).

The effect of in vitro exposure of human erythrocytes to micromolar concentrations of hydroquinone and copper simultaneously on oxidative status-related biochemical parameters was studied. Hydroquinone is a component of cigarette smoke and serum copper level is increased in smokers. Copper forms a complex with hydroquinone and enhances its auto-oxidation to benzoquinone which covalently binds to sulfhydryl group containing compounds like reduced glutathione. In this study, copper increased H(2)O(2) production by hydroquinone. Hydroquinone either alone or in the presence of copper produced a decrease of reduced glutathione level without altering methemoglobin concentration and erythrocyte lipid peroxidation. Catalase inhibition by sodium azide depleted reduced glutathione level further. Copper-hydroquinone complex mediated glutathione depletion in the catalase containing RBC was not decreased by antioxidant, butylated hydroxytoluene. From the known facts and above findings, it is suggested that depletion of reduced glutathione by hydroquinone in the presence of copper in catalase active RBC may be due to the formation of 1, 4 benzoquinone adduct of reduced glutathione and to some extent due to binding of copper to the thiol group of reduced glutathione rather than conversion to oxidized glutathione via reactive oxygen species. Depletion of reduced glutathione by N-ethylmaleimide pretreatment followed by copper-hydroquinone treatment had no effect on methemoglobin level or lipid peroxidation. Furthermore, copper-hydroquinone complex did not increase erythrocyte susceptibility to oxidative stress. This suggests hydroquinone in the presence of copper does not contribute to erythrocyte membrane lipid peroxidation seen in smokers. Criteria for ideal antioxidant supplementation in smokers were suggested.