18-year longitudinal study of cantilevered fixed restorations.

One hundred thirty-seven cantilevered fixed partial dentures made between 1974 and 1990 were clinically and radiographically evaluated. Thirty-three of the prostheses were located in the mandible (11 in the anterior and 22 in the posterior region) and 104 were located in the maxillae (58 anterior prostheses and 46 posterior prostheses). Median duration was 84 +/- 3.6 months. During the 18 years, 41 (30%) failed. Of those that "failed," 28 (68%) were in the maxillae and 13 (32%) were in the mandible. Reasons for failure included abutment fracture (4), loosening with or without caries (18), secondary caries (9), fracture of prosthesis (2), fracture of extension (1), periodontal problems (6), and apical reaction (1). Failures occurred significantly more when endodontically treated abutments were used. More mandibular restorations failed than did maxillary units, but the difference was not significant. The prosthesis length ratio and the crown length-bone ratio did not influence the failure rate. The overall success rate of cantilever fixed prostheses was 70% over a period of 18 years.

Immunocytochemical estrogen and progestin receptor assays in breast cancer with monoclonal antibodies. Histopathologic, demographic, and biochemical correlations and relationship to endocrine response and survival.

Breast cancer specimens from 600 women were assayed for estrogen receptors (ER) using an immunocytochemical assay (ICA) employing the monoclonal antiestrophilin antibody H222 Sp gamma. Results showed significant correlation with biochemical ER determinations as well as with tumor grade and menopausal status. In 449 cases, results of progesterone receptor assay by ICA using the monoclonal anti-PgR antibody KD 68, also correlated significantly with biochemical PgR measurements. The ERICA/PgRICA positivity was significantly more frequent in postmenopausal white women. Colloid carcinomas were most likely to be ERICA positive and PgRICA positive whereas medullary carcinomas were most often negative. In 47 patients with advanced mammary carcinoma, results of ERICA and PgRICA were more closely related to endocrine response than those of ER and PgR by dextran-coated charcoal assay (DCC). In 339 women with Stage I or Stage II breast cancer, ERICA was significantly associated with disease-free survival. Analysis by Cox's proportional hazard model, however, showed PgRICA to be the best predictor of survival and disease-free survival in 197 women at the same stages of disease. These data indicate that ICA is more predictive of prognosis than biochemical ER and PgR. The ease of ICA performance coupled with these results indicate that the method is an acceptable substitute for DCC in analyzing breast cancers for ER/PgR.