[EVALUATION OF THE MEDICAL AND ECONOMIC EFFICIENCY OF NON-INVASIVE PRENATAL TESTING IN MOSCOW].

AIM: to evaluate the medical and economic efficiency of prenatal diagnostics of fetal chromosomal abnormalities (CA) in pregnant women in Moscow using a non-invasive prenatal test (NIPT) as a second-line model. A comparative analysis of the medical and economic efficiency of standard prenatal screening and prenatal screening with NIPT in groups of pregnant women, registered in Moscow, with high and medium fetal CA risk was carried out. Analysis was based on the number of children born with CA and the costs of medical care (direct costs) and social payments (indirect costs), calculated for both scenarios. Following standard prenatal screening 111 children with CA would be born, following prenatal screening with NIPT - only 26. Including NIPT in prenatal diagnostics increases direct costs by 299.97 million rubles and reduces annual indirect costs from 61.19 to 28.95 million rubles. Starting from the 13th year of using NIPT the estimated effect of reducing indirect costs would exceed direct costs. NIPT in prenatal diagnostics can increase the detection of fetal CA and reduce indirect costs. Assessing the indirect costs in economic efficiency enhances the accuracy of the estimate.

[The organizational aspects of security support of participants of clinical testing of vaccine "Gam-COVID-Vac"].

The COVID-19 pandemic resulted in many aftermaths, economic crisis and extra charging of health care. The development of vaccine against SARS-nCoV-2 agent turned out as the priority task of world and Russian medicine and pharmaceutics. The investigation of efficiency and safety of vaccines can be prolonged for many years that can aggravate the observed crisis. Having regard to the global scope and speed of pandemic spreading, the vaccine "Gam-COVID-Vac" was registered with special procedure by the Decree of the Government of the Russian Federation No. 441 of 03.04.2020 for accelerated access to civic turn-over. To monitor safety of vaccine on the basis of international experience, the decision was made to organize the independent Committee of monitoring data concerning efficacy and safety of vaccines applied to prevent COVID-19. The article presents rationale for necessity to create independent committee and to implement such a practice.

Analysis of volume and costs of dental care provided in outpatient settings. / Analiz ob''emov i stoimosti stomatologicheskoi pomoshchi, okazyvaemoi v ambulatornykh usloviyakh.

A conducted analysis of volume and cost of dental care provided in outpatient settings proves the need for harmonization of Russian Ministry of Health's documentation regulating dental checks in adults and children, and the Programme of state guarantees.

[State guarantees for medical dental care provided to the outpatientssetting]. / Gosudarstvennye garantii na meditsinskuiu stomatologicheskuiu pomoshch' v ambulatornykh usloviiakh.

The Provision of free dental care is carried out in accordance with the Programme of State`s guarantees of free rendering to citizens of the Russian Federation medical care. Since 1998, the Programme of State`s guarantees has undergone significant changes, but safeguards are declarative for a particular person (the insured).