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1.
Eur J Pharm Sci ; 153: 105494, 2020 Oct 01.
Article in English | MEDLINE | ID: mdl-32730845

ABSTRACT

Although there have been many advancements in scientific research and development, the cause of epilepsy still remains an open challenge. In spite of high throughput research in the field of anti-epileptic drugs, efficacy void is still prevalent before the researchers. Researchers have persistently been exploring all the possibilities to curb undesirable side effects of the anti-epileptic drugs or looking for a more substantial approach to diminish or cure epilepsy. The drug development has shown a hope to medicinal chemists and researchers to carry further research by going through a substantial literature survey. This review article attempts to describe the recent developments in the anti-epileptic agents, pertaining to different molecular scaffolds considering their structure-activity relationship, docking studies and their mechanism of actions.


Subject(s)
Anticonvulsants , Epilepsy , Anticonvulsants/therapeutic use , Epilepsy/drug therapy , Humans , Structure-Activity Relationship
2.
Arch Pharm (Weinheim) ; 353(7): e1900342, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32319117

ABSTRACT

Epilepsy is the most common neurological disorder, which affects more than 50 million people worldwide. Despite the development and use of several antiepileptic drugs (AEDs), attempted seizure control fails in almost 30% of the individuals treated. Other patients benefit from seizure control by drug therapy at the expense of dose-related toxicity and side effects. These drawbacks with conventional AEDs demand the need for developing more effective and safer antiseizure agents. As a result, extensive efforts are devoted to design and develop new effective molecules as antiepileptics. This area of research to find more effective and safer AEDs is important and challenging. This review describes the future perspective of various 1,3,4-oxadiazole derivatives as anticonvulsant agents and focuses on the design and development of the new effective molecule.


Subject(s)
Anticonvulsants/therapeutic use , Oxadiazoles/therapeutic use , Seizures/drug therapy , Anticonvulsants/chemical synthesis , Anticonvulsants/chemistry , Drug Development , Humans , Oxadiazoles/chemical synthesis , Oxadiazoles/chemistry
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