[Development of postresuscitation morphological changes of hippocampal and cerebellar neurons: common regularities and specific features]. / Razvitie postreanimatsionnykh morfologicheskikh izmenenii neironov gippokampa i mozzhechka: obshchie zakonomernosti i osobennosti.

A comparative morphometric study of postresuscitation changes in the neuronal populations of the pyramidal cells from hyppocampal sector CA1 and Purkinje cells of the lateral cerebellar region in the course of postresuscitation period after 12-minute cardiac arrest in rats has shown that the changes differ in severity and pattern. In the pyramidal cells there were reversible dystrophic alterations of the neurons. Purkinje cells showed death of some neurons, this process progressed in the course of postresuscitation period. A positive effect of the peptide kyotorphin on the brain condition after resuscitation was found but its efficacy in different neuronal populations varied.

[Effect sandostatin on functional and structural recovery of the central nervous system after clinical death]. / Vliianie sandostatina na funktsional'no-strukturnoe vosstanovlenie tsentral'noi nervnoi sistemy posle klinicheskoi smerti.

A behavior examination set was used to reveal a decreased anxiety as well as increased locomotor and exploratory activities and changes in resuscitated animals undergoing different learning tests. A single injection of sandostatin--an analogue of regulatory peptide somatostatin--was found to improve the structural and functional recovery of the central nervous system after a 12-minute cardiac arrest.

Postresuscitation recovery of functional activity of central nervous system in rats during combination treatment with mexidol and neuropeptides delta sleep-inducing peptide and oxytocin.

In experiments on rats we studied the effects of antioxidant and membrane-protecting agent mexidol and neuropeptides delta sleep-inducing peptide and oxytocin administered during resuscitation after 12-min clinical death. Individual and combination treatment with these substances accelerated recovery of the neurological status and partially or completely corrected behavioral disorders associated with changes in the emotional and motivational status. Combined administration of mexidol and oxytocin most significantly promoted postresuscitation recovery of functional activity in the central nervous system.

[Therapy of postresuscitation behavioral disorders with mexidol and kyotorphin]. / Korrektsiia postreanimatsionnykh narushenii povedencheskikh reaktsii meksidolom i kiotorfinom.

A complex of behavioral tests revealed diminished anxiety, increased locomotor and exploratory activities, and changes in different learning tests in resuscitated animals. Mexidol alone and in combination with kyotorphin exhibited antistressogenic and nootropic activities, and led to a compensation of ischemic lesions in rats. It can be stated that a the injection of mexidol in combination with kyotorphin yielded better results due to its neuroprotective effect in the CA1 and CA4 fields of the hippocampus.

[Effect of perftoran on post-resuscitation recovery of the central nervous system]. / Vliianie perftorana na postreanimatsionnoe vosstanovlenie tsentral'noi nervnoi sistemy.

The effect of perfluorane on survival and restorative process in the brain were studied in rats subjected to 12-min arrest of systemic circulation. Perfluorane in a single dose of 5-10 ml/kg was injected intraperitoneally 30 min after the beginning of reanimation. The drug did not affect the postreanimation death of animals and time course of neurologic deficiency disappearance. Perfluorane activated behavioral reactions and prevented development of dystrophic changes in the brain structures of rats highly sensitive to hypoxia.

[Functional-morphologic evaluation of the effect of the regulatory peptide kyotorphin on the status of the CNS in the post-resuscitation period]. / Funktsional'no-morfologicheskaia otsenka vliianiia reguliatornogo peptida kiotorfina na sostoianie TsNS v postreanimatsionnom periode.

Functional and morphological analysis of changes in white rat CNS was made throughout 4 months after 12 minute interruption of circulation. Within 3 months after clinical death and resuscitation the rats' neurological status was normal except some abnormalities in emotions and motives especially noticeable under stress. Moreover, neurons in the hippocampus and cerebellum were destroyed. A single intranasal 0.05 mg/kg dose of kyotorphin--a peptide isolated from the brain of winter-sleeping animals--given 30 min after beginning of resuscitation increased survival, accelerated restoration of neurological status, normalized emotional reactivity, orientation and search behavior, prevented death of neurons in the hippocamp and cerebellum.

[The effect of beta-casomorphin-7 on the level of food and defense motivations in different types of learning]. / Vliianie beta-kazomorfina-7 na uroven' pishchevoi i oboronitel'noi motivatsii pri razlichnykh vidakh obucheniia.

The effects of intraperitoneal administration of the heptapeptide beta-casomorphin-7 (beta-C-7) on learning were investigated in white rats using T-maze, active and passive avoidance tests. The substance injected in the dose of 5 mg/kg 5 min prior to training accelerated the acquisition of food-reinforced task increasing the number of correct trials in T-maze. The same injection in the dose of 1 mg/kg impaired the acquisition of avoidance tasks. The heptapeptide didn't influence food motivation and consolidation of memory trace. The data obtained support the idea that beta-C-7 attenuated manifestations of defensive motivation.

[The use of reaferon in treating patients with protracted viral hepatitis]. / Primenenie reaferona v lechenii bol'nykh zatiazhnym virusnym gepatitom.

The paper reports the results of a randomized clinicoimmunological trial of domestic recombinant alpha 2-interferon (reaferon) in 30 patients with protracted viral hepatitis (27 subjects had viral hepatitis B and 3 patients HBV + HDV-coinfection). The reaferon treatment started on the disease week 7-8 and lasted for 2 months (1 x 10(6) IU, once a week, i.m.). VHB patients benefited from reaferon treatment as evident from improved clinical and laboratory indices, cases of complete cure and the agent elimination. In a protracted course of HBV + HDV coinfection reaferon in the above doses failed to produce any effect.

[Effectiveness of using recombinant interferon alfa2 (reaferon) combined with antioxidants in children with acute hepatitis B]. / Effektivnost' primeneniia rekombinantnogo alfa2 interferona (reaferona) v komplekse s antioksidantami pri ostrom virusnom gepatite B u detei.

The authors describe the results of the first experience gained with the use of recombinant alpha 2-interferon in children with acute viral hepatitis B. The drug was administered rectally in combination with antioxidants (tocopherol). The study was carried out by the double blind method with randomization and two control groups (given tocopherol alone or placebo alone). 73 children with acute viral hepatitis B were examined. The therapeutic combination reaferon plus tocopherol was established to favour more rapid elimination of dyspeptic and abdominal phenomena, to shorten the time of the liver and spleen size increase, duration of hyperfermentemia, to provide for an accelerated reduction of HBsAg titers, elimination of HBeAg and seroconversion, to stimulate alpha-interferon production by leukocytes, and to activate the system of mononuclear phagocytes.