[The prenatal diagnosis of placental insufficiency in pregnant women with a herpetic infection]. / Prenatal'naia diagnostika platsentarnoi nedostatochnosti u beremennykh s gerpeticheskoi infektsiei.

Our objective in this study was to find out exactly the diagnostic criteria for dysfunction of the fetoplacental complex in pregnant women with herpes infection. A total of 62 pregnant women who ran a high risk for intrauterine infection were examined. As many as 87 percent of female patients were found to be PHV-infected displaying manifestations of the immunodeficiency syndrome such as increased pathological antibody formation and activation of mechanisms of cell immunosuppression, which fact results in disturbance in the fetomaternal immune relations. Routine methods of obstetric examination lack informative value, which fact necessitates conducting a combined echographic and immunological investigation in order that we might be able to establish a perinatal prognosis.

[The clinical and hemodynamic aspects of using peripheral vasodilators in hypertension in pregnant women]. / Klinicheskie i gemodinamicheskie aspekty primeneniia perifericheskikh vazodilatorov pri gipertenzii beremennykh.

The clinical efficacy of various vasodilators characterized by different direction of the hemodynamic action (arteriolar, mixed, venous) was assessed in therapy of the slight and medium-severe hypertensive syndrome in 92 pregnant women aged 19-36 at pregnancy terms of 24 to 39 weeks. The drugs were administered as monotherapy. Twenty-two healthy women with the normal gestation process made up the reference group. Echocardiograms have shown before the course of treatment the hyper-, hypo-, and eukinetic changes in the hemodynamics (26, 31, 35 cases, respectively). Venodilators (sustonit-mitte) were found the most effective in the pregnant women with the hyperkinetic type of circulation; in patients with the eu- and hypokinetic type both mixed vasodilators and the arteriolodilators (prazosin, cordafen) were effective. Venodilators are not recommended for patients with the hyperkinetic circulation type because of an undesirable reduction of myocardial contractility.

[Immunologic aspects of the fetal growth retardation syndrome]. / Ob immunologicheskikh aspektakh sindroma zaderzhki razvitiia ploda.

Serial measurements of allo- and autoimmune lymphocytotoxic antibodies (LCT-AB), circulating immune complexes (CIC) and heterophilic hemolysins were carried out over pregnancy weeks 24-40 in 63 pregnant women with small-for-date fetuses, 63 ones with other pregnancy complications, and in 15 ones with normal pregnancy. The mean allo- and auto-LCT-AB levels remained unchanged over the course of pregnancy and were virtually the same in all the examinees. CIC and heterophilic hemolysin levels were found growing in women with small-for-date fetuses starting from pregnancy week 28, as against the two reference groups. A direct relationship between abnormally high heterophilic hemolysin levels and blood rheology disorders could be traced. The incidence of unfavorable perinatal outcomes was increasing if heterophilic hemolysin levels surpassed 1.1 U optic density and the placenta was thin. These results permit considering the small-for-date fetus syndrome as a manifestation of immunity conflict in pregnancy.