ABSTRACT
The genetic characteristics are key risk factors of development of many human neoplasms including B-cell tumors of lymphatic system. The relationship between polymorphic variants of genes FCGR2A (His 1 66Agr), CD14 (C-159T). IL1ß (T-31C), IL2 (7:330G) and 7LR2 (Arg753Ghn) and development of various forms of B-cell tumors of lymphatic system in 80 patients was investigated. The statistically significant differences of rates of particiular genotypes of single nucleotid polymorphisms of genes FCGR2A, CD14. IL1ß, IL2 and TLR2 in patients with indolent and aggressive types of course of non-Hodgkin lymphoma and also multiple myeloma. The results prove hypothesis that genetic variants of genes of inborn immune response effect the origin and character of course of different types of lymphoproliferative diseases. The markers can become additional prognostic characteristics of benign and aggressive course of tumors.
Subject(s)
Genetic Predisposition to Disease , Lymphoma, B-Cell/genetics , Lymphoma, Non-Hodgkin/genetics , Multiple Myeloma/genetics , Adult , Aged , Female , Genotype , Humans , Interleukin-1beta/genetics , Interleukin-2/genetics , Lipopolysaccharide Receptors/genetics , Lymphoma, B-Cell/pathology , Lymphoma, Non-Hodgkin/pathology , Male , Middle Aged , Multiple Myeloma/pathology , Polymorphism, Single Nucleotide , Prognosis , Receptors, IgG/genetics , Toll-Like Receptor 2/geneticsABSTRACT
The sample consisted of 102 patients with hemophilia infected and non-infected with hepatitis viruses. It is established that in case of inhibitory form of hemophilia concentration of IgG increases at the expense of subclass II and in case of non-inhibitory form of hemophilia valuable increase of concentration of IgG occurs at the expense of subclasses I, II and III under concomitant chronic hepatitis. No significant differences between these groups in levels of antibodies to factors VIII and IX is established.
