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1.
Article in Russian | MEDLINE | ID: mdl-30499494

ABSTRACT

AIM: To evaluate the efficacy of cytoflavin inclusion in the complex therapy of patients with multiple sclerosis in the remitting form during the period of exacerbation. MATERIAL AND METHODS: The results of therapy of 41 patients matched for sex, age and parameters of clinical and laboratory data were analyzed. Depending on the scheme of therapy, patients were divided into 2 groups: patients of the first group (n=22) received hormonal therapy with methylprednisolone. Patients of group II (n=19) received cytoflavin. The efficacy of treatment was assessed by a set of clinical and laboratory indicators in dynamics - before the start of therapy, with a 10-day interval and after treatment. The neurological status was assessed with the most commonly used scales (functional system scale (FS), EDSS scale), also neuroimaging data were assessed. RESULTS AND CONCLUSION: The inclusion of cytoflavin as an antioxidant and neuroprotective agent in the therapy of patients with multiple sclerosis in the acute phase increased the efficacy of basic (hormonal) therapy, which is manifested in a significant decrease in the severity of neurologic symptoms and visual system disorders and fewer cases of non-response to treatment.


Subject(s)
Flavin Mononucleotide , Inosine Diphosphate , Multiple Sclerosis , Niacinamide , Succinates , Drug Combinations , Flavin Mononucleotide/therapeutic use , Humans , Inosine Diphosphate/therapeutic use , Multiple Sclerosis/drug therapy , Niacinamide/therapeutic use , Succinates/therapeutic use , Treatment Outcome
3.
Article in Russian | MEDLINE | ID: mdl-14716998

ABSTRACT

As the result of the high flood, an increase in the area of anopheligenic water reservoirs occurred on the inundated territories, which created favorable conditions for the proliferation of Anopheles mosquitoes, the vectors of malarial plasmodia, thus creating the threat of the formation of the local sources of malaria in case of its penetration from other regions unfavorable with respect to this disease. In the affected towns and regions hydrotechnical measures aimed at decreasing the surface of anopheligenic water reservoirs, as well as measures aimed at the decrease in the number of the larval and imaginal stages in the development of mosquitoes, were taken, which made it possible to prevent the probable epidemiological aggravations in malaria.


Subject(s)
Disasters , Malaria/epidemiology , Malaria/prevention & control , Water , Animals , Anopheles/parasitology , Government Agencies/organization & administration , Insect Vectors/parasitology , Malaria/transmission , Population Surveillance , Retrospective Studies , Russia/epidemiology , Sanitation/standards
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