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1.
Nat Prod Res ; 36(2): 515-522, 2022 Jan.
Article in English | MEDLINE | ID: mdl-32627596

ABSTRACT

A new ceramide is being reported herein together with six known compounds from the methanol extract of the leaves of Lannea schimperi (Hochst. ex A.Rich.) Engl. The metabolites were obtained through repeated open column chromatography and were characterized by spectroscopic and spectrometric techniques. The radical-scavenging activity of the crude extract and isolated compounds was evaluated using the DPPH radical. The obtained results suggest the studied species as prominent candidate to fight reactive oxygen species (ROS).


Subject(s)
Anacardiaceae , Ceramides , Antioxidants , Methanol , Plant Extracts , Plant Leaves
2.
Nat Prod Res ; 36(17): 4379-4387, 2022 Sep.
Article in English | MEDLINE | ID: mdl-34694175

ABSTRACT

A phytochemical study of the methanol extract of the fruit of Maesa lanceolata resulted in the isolation of a new alkenylbenzoquinone (1), alongside the known compounds (Z)-2,5-dihydroxy-6-methyl-3-(pentadec-10'-enyl)-1,4-benzoquinone (2), 2,5-dihydroxy-6-methyl-3-(nonadec-14'-enyl)-1,4-benzoquinone (3), 2,5-dihydroxy-6-methyl-3-(tridecyl)-1,4-benzoquinone (4), (2S,3S,4R,2'R,9E)-[2'-hydroxytetraeicosanoyl]-2-aminooctadec-9-ene-1,3,4-triol (5), monopalmitin (glyceryl palmitate) (6), lupeol (7), and 3-O-(ß-D-glucopyranoside)-ß-sitosterol (8). The structures of the compounds were established by the means of spectroscopic (1 D- and 2 D-NMR) and spectrometric techniques (MS). The isolated compounds were assessed for their antibacterial, cytotoxic, and antiradical activities. Compound 2 showed moderate activity against Staphylococcus warneri (DSMZ 20036), while the other compounds were inactive. The two quinones 1 and 2 were significantly cytotoxic, with IC50 values of 0.005 µM and 12.5 µM respectively, and were weakly active towards DPPH radical (IC50 >250 µg/mL).


Subject(s)
Fruit , Maesa , Anti-Bacterial Agents/analysis , Anti-Bacterial Agents/pharmacology , Benzoquinones/chemistry , Fruit/chemistry , Molecular Structure , Plant Extracts/chemistry
3.
Planta Med ; 86(17): 1298-1303, 2020 Nov.
Article in English | MEDLINE | ID: mdl-32726812

ABSTRACT

A phytochemical study of the methanol extract of the leaves of Embelia schimperi resulted in the isolation of three new alkenylresorcinols, 1:  - 3: , together with the known analogs 4:  - 7: . Their structures were established by a combination of spectroscopic techniques. Compounds 1:  - 7: exhibited moderate cytotoxic activity against human cervical cancer cells HeLa-S3 and more pronounced antimicrobial properties towards bacteria and filamentous fungi. The present study falls into an ongoing research project on the characterization of bioactive phenolic lipids from plants of the family Primulaceae.


Subject(s)
Anti-Infective Agents , Embelia , Anti-Infective Agents/pharmacology , Humans , Phytochemicals , Plant Extracts/pharmacology , Plant Leaves
4.
Nat Prod Res ; 33(13): 1909-1915, 2019 Jul.
Article in English | MEDLINE | ID: mdl-29798678

ABSTRACT

A new alkylbenzoquinone named embeliquinone (1) together with five known compounds, lupeol (2), 3-O-[6'-O-palmitoyl-ß-d-glucosyl]-spinasta-7,22(23)-diene (3), quercetin (4), (2S,3S,4R,8E)-2-[(2'R)-2'-hydroxy-heneicosanoylamino]-heneicosane-1,3,4-triol-8-ene (5), and ß-sitosterol-3-O-ß-d-glucopyranoside (6) were isolated from the MeOH leaf extract of Embelia rowlandii by using repeated open column chromatography techniques. The structure of the new compound was characterized by analyses of 1D- and 2D-NMR, and MS data. Embeliquinone (1) had moderate anti-cell proliferation activity against A549 cell line with the IC50 value of 21.8 µM. In addition, 1 exhibited weak antibacterial activities against Klebsiella pneumoniae and Staphylococcus aureus with an MIC value of 206.0 µM in both cases.


Subject(s)
Anti-Bacterial Agents/pharmacology , Benzoquinones/pharmacology , Embelia/chemistry , A549 Cells , Anti-Bacterial Agents/chemistry , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/pharmacology , Benzoquinones/chemistry , Cell Proliferation/drug effects , Drug Evaluation, Preclinical/methods , Humans , Klebsiella pneumoniae/drug effects , MCF-7 Cells , Magnetic Resonance Spectroscopy , Microbial Sensitivity Tests , Molecular Structure , Plant Extracts/chemistry , Plant Leaves/chemistry , Staphylococcus aureus/drug effects
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