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Fertil Steril ; 95(5): 1568-73, 2011 Apr.
Article in English | MEDLINE | ID: mdl-21300339

ABSTRACT

OBJECTIVE: To compare the efficacy of leuprolide and continuous oral contraceptives in the treatment of endometriosis-associated pain. DESIGN: Prospective, randomized, double-blind controlled trial. SETTING: Academic medical centers in Rochester, New York, and Boston, Massachusetts. PATIENT(S): Forty-seven women with endometriosis-associated pelvic pain. INTERVENTION(S): Forty-eight weeks of either depot leuprolide, 11.25 mg IM every 12 weeks with hormonal add-back using norethindrone acetate 5 mg orally, daily; or a generic monophasic oral contraceptive (1 mg norethindrone + 35 mg ethinyl estradiol) given daily. MAIN OUTCOME MEASURE(S): Biberoglu and Behrman (B&B) pain scores, numerical rating scores (NRS), Beck Depression Inventory (BDI), and Index of Sexual Satisfaction (ISS). RESULT(S): Based on enrollment of 47 women randomized to continuous oral contraceptives and to leuprolide, there were statistically significant declines in B&B, NRS, and BDI scores from baseline in both groups. There were no significant differences, however, in the extent of reduction in these measures between the groups. CONCLUSION(S): Leuprolide and continuous oral contraceptives appear to be equally effective in the treatment of endometriosis-associated pelvic pain.


Subject(s)
Contraceptives, Oral, Hormonal/therapeutic use , Endometriosis/drug therapy , Leuprolide/therapeutic use , Pelvic Pain/drug therapy , Peritoneal Diseases/drug therapy , Adult , Double-Blind Method , Endometriosis/complications , Female , Fertility Agents, Female/therapeutic use , Humans , Patient Satisfaction , Pelvic Pain/etiology , Peritoneal Diseases/complications , Quality of Life , Sexuality/drug effects , Sexuality/physiology , Young Adult
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