Epilepsy in Africa: a multifaceted perspective on diagnosis, treatment, and community support.

Epilepsy is the most widespread neurological disorder in Africa, affecting an estimated 25 million people. The disorder is characterized by recurrent seizures, which can be caused by a variety of factors, including past trauma, central nervous system infections, and genetic disorders. Diagnosis and treatment of epilepsy are challenging in African patients due to several factors, including the low socioeconomic status of the residents and limited access to appropriate medication. Phenobarbital remains the only drug widely available to patients, but it is not always effective and can have significant side effects. In addition to the medical challenges, individuals with epilepsy also face a lot of social stigmas in Africa. Widespread superstitions and false beliefs lead to prejudices against these people, making it difficult for them to live fulfilling social lives. With the development of new treatment modalities, such as gene therapy, stem cell therapy, and P-glycoprotein inhibitors, it is more important now than ever to increase the research output for the African region to create the best possible treatment and maximize patient outcomes.

Recognizing vaccine wastage in Georgia.

The COVID-19 vaccination program in the country of Georgia began on March 15, 2021, and reached its peak in the summer of 2021. Throughout the process, individuals had access to over 5.3 million doses of COVID-19 vaccines which were acquired from various sources as reported by the National Center for Disease Control and Public Health (NCDC). Factors such as widespread vaccine hesitancy and low demand led to reduced vaccine uptake, low vaccination rates, and vaccine wastage. As of August 2022, a total of 2,922,000 doses have been administered with less than 35% of the Georgian population, or 1,276,000 people, fully vaccinated with at least two doses. Over 400,000 doses have expired at NCDC's storage facilities due to low demand. Many more doses have been wasted at administration points, and there is a risk of wasting more in the future. The key reasons for wastage are widespread public hesitancy toward the newly developed vaccines, inconsistent policies and communication from government officials, rampant disinformation, and ambiguity from influential bodies in Georgian society. Despite certain limitations, logistics is not among the leading causes of wastage, as Georgia was able to develop a strong cold-chain and vaccine administration infrastructure through years of international cooperation that allowed for efficient management of the COVID-19 vaccination process. Lastly, in addition to establishing a robust reporting system and ensuring transparency of vaccine wastage data, relevant studies based on original data are required to better understand the problem. Conducting studies on health literacy in the country as a baseline for long-term interventions, as well as research that will increasingly evidence-inform further pandemic response are being recommended.