ABSTRACT
Glucagonoma Syndrome is a rare syndrome comprising hyperglucagonemia, diabetes mellitus, necrolytic migratory erythema and hypoaminoacidemia in the setting of a glucagon producing, alpha cell tumour of the pancreas. We report a case of Glucagonoma Syndrome palliatively treated successfully with octreotide. In addition to classical clinical and biochemical findings, this patient also had a Glomus Jugulare tumour, and Empty Sella Syndrome and demonstrated an unusual pattern of plasma lactate dehydrogenase isoenzymes, features not previously reported in this syndrome.
Subject(s)
Glucagonoma/drug therapy , Octreotide/therapeutic use , Pancreatic Neoplasms/drug therapy , Empty Sella Syndrome/complications , Female , Glomus Jugulare Tumor/pathology , Glucagonoma/complications , Glucagonoma/enzymology , Glucagonoma/pathology , Humans , Isoenzymes , L-Lactate Dehydrogenase/metabolism , Middle Aged , Multiple Endocrine Neoplasia Type 1/pathology , Neoplasms, Second Primary/pathology , Palliative Care , Pancreatic Neoplasms/complications , Pancreatic Neoplasms/enzymology , Pancreatic Neoplasms/pathology , SyndromeABSTRACT
Some skin problems either occur exclusively in summer, or are exacerbated by heat and humidity. The more common of these conditions are discussed briefly in this article.
Subject(s)
Hot Temperature/adverse effects , Seasons , Skin Diseases, Infectious/etiology , Female , Humans , Male , Miliaria/therapy , Risk Factors , Skin Diseases, Infectious/pathology , Skin Diseases, Infectious/therapy , Sunburn/therapyABSTRACT
The reports from all keratoacanthoma curettings which were submitted to a Brisbane pathology practice over a two year period were reviewed. Those followed up for less than 12 months were not included in the analysis, unless recurrence occurred. Of 150 submitted, 111 keratoacanthomas in 106 patients could be studied. The sex distribution was almost equal, and the mean age of patients was 65 years for females and 64 years for males. Four keratoacanthomas recurred over periods ranging from 3 to 26 months. Curettage and electrodesiccation is shown to be an efficient and effective form of therapy.
Subject(s)
Curettage , Desiccation , Keratoacanthoma/surgery , Skin Diseases/surgery , Adult , Aged , Aged, 80 and over , Evaluation Studies as Topic , Female , Follow-Up Studies , Humans , Keratoacanthoma/pathology , Male , Middle Aged , Recurrence , Skin Diseases/pathologySubject(s)
Hirsutism , Female , Hirsutism/diagnosis , Hirsutism/etiology , Hirsutism/therapy , Humans , Hypertrichosis/etiology , Hypertrichosis/therapyABSTRACT
Multiple small hyperkeratoses were observed in a 42-year-old woman. They had first appeared in early adult life. There was a history of an apparently identical disorder affecting her father, her brother, and her brother's son. A similar condition has been described in four previous reports in which seven individual cases have been documented. Four had a positive family history, bringing the total number of previously known cases to 14. The disorder is characterized by the development in early adult life of widely disseminated small spikes of keratin that are unrelated to hair follicles. Microscopic examination shows digitate orthokeratosis with moderate epidermal cell hyperplasia and a normal underlying dermis.
