ABSTRACT
An adult drug abuser with endocarditis due to a group II Staphylococcus aureus developed the staphylococcal scalded skin syndrome (SSSS). Studies of the patient's immune function found cell-mediated immunity (CMI) to be essentially normal; thus, previous suggestions that deficient CMI is required in adults who develop SSSS seem unfounded. Pathogenesis, diagnosis, and therapy of SSSS and its differentiation from drug-induced hypersensitivity reaction are discussed in detail.
Subject(s)
Staphylococcal Infections/diagnosis , Stevens-Johnson Syndrome/diagnosis , Adult , Aged , Diagnosis, Differential , Drug Hypersensitivity/diagnosis , Female , Humans , Immunity, Cellular , Male , Middle Aged , Staphylococcal Infections/immunology , Staphylococcal Infections/pathology , Stevens-Johnson Syndrome/immunology , Stevens-Johnson Syndrome/pathology , Substance-Related Disorders/complications , SyndromeABSTRACT
Sulfasalazine hepatotoxicity has been poorly documented in the literature. We report a case of a young female with inflammatory bowel disease who developed severe hepatotoxicity as part of a systemic hypersensitivity reaction to sulfasalazine. The clinical, biochemical, and histopathological features resemble those of sulfonamide-induced hepatic injury. Although rare, our case as well as previous reports indicate the serious nature of the illness.