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Clin Transl Oncol ; 21(7): 954-959, 2019 Jul.
Article in English | MEDLINE | ID: mdl-30565082

ABSTRACT

INTRODUCTION: Our aim is to find features that define prognosis in surgically resected ductal pancreatic adenocarcinoma readily accessible in everyday practice. MATERIALS AND METHODS: Longitudinal retrospective case series of pancreatic adenocarcinoma operated with a curative intent in a large tertiary hospital in Madrid between 2009 and 2015. RESULTS: 162 were enrolled. 40.8% survived less than 1 year. Multivariate Cox's regression model revealed that gender, presence of symptoms, T and N stage independently influenced progression-free survival, while overall survival was determined by gender, smoking, presence of symptoms and N stage. Logistic regression analysis revealed that only symptoms at diagnosis could predict death, while gender, symptoms, histopathological type, vessel invasion, T stage and necrosis could independently predict recurrence. DISCUSSION: Our series show that patients with symptomatic disease at the time of diagnosis and females showed a shorter progression-free and overall survival. We herein propose a regression model to predict outcome.


Subject(s)
Adenocarcinoma/pathology , Carcinoma, Pancreatic Ductal/pathology , Molecular Medicine , Neoplasm Recurrence, Local/pathology , Pancreatic Neoplasms/pathology , Pancreaticoduodenectomy/methods , Adenocarcinoma/surgery , Aged , Carcinoma, Pancreatic Ductal/surgery , Disease Progression , Female , Follow-Up Studies , Humans , Longitudinal Studies , Male , Neoplasm Recurrence, Local/surgery , Pancreatic Neoplasms/surgery , Prognosis , Retrospective Studies
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