Subject(s)
Endocarditis, Bacterial/physiopathology , Heart Septal Defects, Atrial/physiopathology , Ventricular Function, Right/physiology , Adult , Child , Endocarditis, Bacterial/etiology , Endocarditis, Bacterial/surgery , Heart Septal Defects, Atrial/complications , Heart Septal Defects, Atrial/surgery , Hemodynamics/physiology , Humans , Postoperative PeriodABSTRACT
Intracardiac central hemodynamic parameters were studied and myocardial functional states were assessed in 46 patients with congenital heart disease, 20 of them had stenosed pulmonary artery; 26, presented with secondary atrial septal defect complicated with bacterial endocarditis. The mechanisms responsible for myocardial adaptation after defect correction are discussed. Attention is given to inadequacy of the performance of the heterometric mechanism of regulation due to altered elasticoviscous properties of the cardiac muscle. Plotting the functional curves enables one to gain an insight into the functional states of the myocardium.
Subject(s)
Cardiomegaly/physiopathology , Endocarditis, Bacterial/physiopathology , Heart Septal Defects, Atrial/physiopathology , Myocardial Contraction , Pulmonary Valve Stenosis/physiopathology , Adolescent , Adult , Cardiomegaly/complications , Child , Child, Preschool , Endocarditis, Bacterial/complications , Heart Septal Defects, Atrial/complications , Heart Septal Defects, Atrial/surgery , Humans , Pulmonary Valve Stenosis/complications , Pulmonary Valve Stenosis/surgeryABSTRACT
Abnormal and compensatory reactions, arising in the course of myocardial adaptation to a new hemodynamic situation following the elimination of isolated pulmonary arterial stenosis have been studied. Rational treatment is proposed for the early postoperative period in this category of patients.
Subject(s)
Adaptation, Physiological , Myocardial Contraction , Pulmonary Valve Stenosis/surgery , Adolescent , Adult , Child , Child, Preschool , Heart Ventricles , Hemodynamics , HumansSubject(s)
Heart Failure/etiology , Pericardiectomy/adverse effects , Postoperative Complications/etiology , Adult , Heart/physiopathology , Heart Failure/physiopathology , Hemodynamics , Humans , Middle Aged , Pericarditis, Constrictive/complications , Pericarditis, Constrictive/physiopathology , Pericarditis, Constrictive/surgery , Postoperative Complications/physiopathologySubject(s)
Pericardium/surgery , Postoperative Complications/diagnosis , Adolescent , Adult , Aged , Child , Child, Preschool , Electrocardiography , Heart Failure/diagnosis , Heart Failure/etiology , Heart Failure/physiopathology , Hemodynamics , Humans , Infant , Male , Middle Aged , Myocardial Contraction , Pericarditis, Constrictive/complications , Pericarditis, Constrictive/physiopathology , Pericarditis, Constrictive/surgery , Postoperative Complications/etiology , Postoperative Complications/physiopathologyABSTRACT
Study of the amino acid spectrum in the blood plasma of 45 patients with multiple sclerosis (MS) demonstrated marked deaminoacidemia with a tendency toward hypoaminoacidemia in all those studied. Characteristic significant changes in the chromatogram of free amino acids were detected at the stages of rapid and slow disease progression, during disease remissions and at the stage of stabilization. The disclosed disorders of the composition of free amino acids contribute to the better understanding of the disease pathogenesis and may serve as a differential-diagnostic criterion in various forms of the MS course. They also make it possible to outline rational directions in the comprehensive management of MS.
