ABSTRACT
An analysis was carried out of chromosomal site-fragility in patients with primary multiple tumors and familial breast cancer. A possible correlation is discussed between fragile sites, breakpoints in chromosome rearrangements in cancer patients and the localization of oncogenes mapped in chromosomal regions involved in said rearrangements.
Subject(s)
Breast Neoplasms/genetics , Chromosome Fragility , Neoplasms, Multiple Primary/genetics , Breast Neoplasms/blood , Cells, Cultured/ultrastructure , Chromosome Aberrations , Chromosome Fragile Sites , Female , Genetic Markers , Humans , Lymphocytes/ultrastructure , Neoplasms, Multiple Primary/bloodABSTRACT
A clinico-genealogic investigation was carried out in 216 patients with endometrial cancer. Familial accumulation of endometrial and other cancer incidence was established. The segregation rates appeared to be lower than those expected from simple Mendelian models (2-11%). A multifactorial nature of endometrial cancer in overall susceptibility to the disease was found to be at 61%. A genetic correlation analysis showed endometrial cancer to share common genes with breast and gastric cancer in females. Tables of recurrent risk of the disease for relatives were prepared to be used in medico-genetic counseling.
Subject(s)
Endometrial Neoplasms/genetics , Genetics, Population , Adult , Endometrial Neoplasms/epidemiology , Female , Genotype , Humans , Incidence , Male , Middle Aged , Neoplasms/epidemiology , Neoplasms/genetics , Phenotype , Risk Factors , Ukraine/epidemiologyABSTRACT
Polymorphism of the human c-Ha-ras-1 gene has been analysed in 66 BamHI restricted DNAs from blood of 35 patients with "inherited" breast cancer, 7 fibroadenoma patients, 13 healthy first-degree relatives and 11 unaffected controls. Two "common" and four "unusual" alleles were detected. The frequency of "common" (6.6 and 7.4 kb) and "unusual" (6.9 kb) alleles was identical to that in the control and unaffected groups (65.8, 17.1 and 7.1%). Rare alleles (7.6 and 7.8 kb) were only detected in breast cancer patients and in healthy first-degree relatives. A 8.0 kb allele specific for control patients was also detected. No absolute relationship between the genetic predisposition to breast cancer and the Ha-ras genotype was assumed.
Subject(s)
Breast Neoplasms/genetics , Genes, ras/genetics , Alleles , Female , Genetic Predisposition to Disease , Humans , Pedigree , Polymorphism, Genetic/geneticsABSTRACT
As a result of clinico-genealogical analysis of data on 691 skin melanoma patients, a classification of skin melanoma was elaborated which reflected the etiologic heterogeneity of the disease. Inheritable and non-inheritable forms of skin melanoma were identified. The inheritable tumor group included familial disease (2%) and tumors developing against the background of hereditary diseases and syndromes (32.7%). The data obtained served as basis for the identification of families with high genetic predisposition to skin melanoma development and for the assessment of individual risk of the disease in patients' relatives.
Subject(s)
Melanoma/genetics , Skin Neoplasms/genetics , Adult , Dysplastic Nevus Syndrome/genetics , Female , Humans , Male , Melanoma/classification , Middle Aged , Skin Neoplasms/classificationABSTRACT
The authors sum up the results of clinical and genealogic examinations of 2460 patients with most prevalent tumors, i.e. gastric and mammary carcinomas, melanomas. The obtained values of segregation frequencies for these tumors have proved to be lower than the theoretically expected values for monogenic types of inheritance. A genetic and epidemiologic approach, employed in the tumors analysis, has demonstrated the multifactorial nature of these tumors: the contribution of the genetic factors in mammary carcinoma has made up 52%, in gastric carcinoma 22% for male and 41.1% for female subjects, with the X-chromosome-linked genetic components making up 19%. The studies have shown the possibility of genetic heterogeneity of the tumor forms, identically localized. Basing on these data, the authors have plotted 'repeated risk tables' to assess the potentiality of new cases of the disease in the patients' families; such tables may be useful for practical medicogenetic counselling.
Subject(s)
Breast Neoplasms/genetics , Melanoma/genetics , Skin Neoplasms/genetics , Stomach Neoplasms/genetics , Adult , Age Factors , Breast Neoplasms/epidemiology , Breast Neoplasms/etiology , Female , Humans , Male , Melanoma/epidemiology , Melanoma/etiology , Middle Aged , Moscow , Sex Factors , Skin Neoplasms/epidemiology , Skin Neoplasms/etiology , Stomach Neoplasms/epidemiology , Stomach Neoplasms/etiologyABSTRACT
The multifactorial nature of breast cancer was established based on population and family study, the contribution of genetic factors being 52% (premenopausal--62 and postmenopausal--39%). Genetic heterogeneity of different coefficients of inheritance of breast cancer with the portion of common genes was shown to be 53%. The analysis of breast cancer interaction with other malignant neoplasms revealed that the development of other malignant neoplasms was the result of the influence of partially common genes. On the basis of data obtained in this study, the tables of repeated risk for the relatives have been worked out which may be used for medico-genetic consultations.
Subject(s)
Breast Neoplasms/genetics , Breast Neoplasms/epidemiology , Female , Genotype , Humans , Menopause/genetics , Moscow , Phenotype , Risk FactorsABSTRACT
The data on clinico-genealogy studies of 1046 probands with breast cancer and their relatives are presented. The nature of inheritance corresponded to the Mendelian model. As to other families, there is no strong evidence for the monogene model both with complete and incomplete penetrance of mutant homo- and heterozygotes. Penetrance of homozygotes was 7.9-30.5%, this being 2.0-7.3% for heterozygotes. The conclusion is drawn that it is necessary to consider the regularities of inheritance of breast cancer in the light of the multifactorial model.
