ABSTRACT
We present the case of a 21-year-old man with advanced refractory Parkinson's disease treated with Duodopa continuous infusion. With this therapy, the patient had a spectacular recovery but after six months, he experienced an aggravation of his symptoms. A failure of his pumping system was suspected but we discovered that the jejunal tube was blocked due to a knot around a bezoar. This is the first complication of this kind described with the Duodopa infusion technique.
Subject(s)
Antiparkinson Agents/administration & dosage , Antiparkinson Agents/adverse effects , Bezoars/etiology , Carbidopa/administration & dosage , Carbidopa/adverse effects , Jejunum , Levodopa/administration & dosage , Levodopa/adverse effects , Parkinson Disease/drug therapy , Bezoars/pathology , Drug Combinations , Gastrostomy , Humans , Infusion Pumps/adverse effects , Male , Young AdultABSTRACT
Alterations of normal function of interstitial cells of Cajal (ICC) are reported in many intestinal disorders. Diagnosis of their involvement is rare (infrequent), but necessary to propose a specific treatment. This article reviews the place of ICC in the pathogenesis of achalasia, gastroesophageal reflux disease, infantile hypertrophic pyloric stenosis, chronic intestinal pseudo-obstruction and slow transit constipation. Moreover we discuss the role of the Cajal cells in the development of stromal tumors of the gastrointestinal tract.
