Beneficial effects of dietary fibre supplementation of a high-fat diet on fetal development in rats.

The objective of the present study was to investigate the effects of the addition of fibre and the antioxidant N-acetylcysteine (NAC) to fat-rich diets on fetal intrauterine development in rats. A total of eighty virgin female Sprague-Dawley rats were fed a control diet, a high-fat diet (HF), a high-fat and high-fibre diet (HFF) or a high-fat NAC diet until day 19·5 of gestation. Maternal HFF consumption resulted in a significantly higher mean fetal number and placental weight than in the other groups (P < 0·05). The HFF diet significantly abrogated HF-induced decreases in maternal serum and placental superoxide anion and hydroxyl radical scavenging capacities (P < 0·05); partially abrogated HF-induced increases in maternal serum and placental malondialdehyde (MDA) and protein carbonyl concentrations (maternal serum MDA and placental protein carbonyl, P < 0·05); resulted in significantly higher fetal liver total superoxide dismutase (SOD), Cu- and Zn-containing SOD and Mn-containing SOD (Mn-SOD) activities than in the HF group (P < 0·05). Furthermore, mRNA expressions of hypoxia-inducible factor 1-α, thioredoxin 2 and Mn-SOD in fetal liver and Mn-SOD in fetal heart and placental GLUT3 in the HFF group were higher than those in the other groups (P < 0·05). The inclusion of dietary fibre in the HF diet was more effective than NAC supplementation in maintaining maternal serum and placental superoxide anion and hydroxyl radical scavenging capacities close to those of the control. These results suggest that maternal fibre intake during pregnancy is beneficial for fetal intrauterine development possibly through the improvement of maternal, placental and fetal antioxidant capacities and placental nutrient transfer capacity.

Analysis of normalized point source sensitivity as a performance metric for large telescopes.

We investigate a new metric, the normalized point source sensitivity (PSSN), for characterizing the seeing-limited performance of large telescopes. As the PSSN metric is directly related to the photometric error of background limited observations, it represents the efficiency loss in telescope observing time. The PSSN metric properly accounts for the optical consequences of wave front spatial frequency distributions due to different error sources, which differentiates from traditional metrics such as the 80% encircled energy diameter and the central intensity ratio. We analytically show that multiplication of individual PSSN values due to individual errors is a good approximation for the total PSSN when various errors are considered simultaneously. We also numerically confirm this feature for Zernike aberrations as well as for the numerous error sources considered in the error budget of the Thirty Meter Telescope (TMT) using a ray optics simulator. Additionally, we discuss other pertinent features of the PSSN, including its relations to Zernike aberration, RMS wave front error, and central intensity ratio.

Algorithm for the identification of malfunctioning sensors in the control systems of segmented mirror telescopes.

The active control systems of segmented mirror telescopes are vulnerable to a malfunction of a few (or even one) of their segment edge sensors, the effects of which can propagate through the entire system and seriously compromise the overall telescope image quality. Since there are thousands of such sensors in the extremely large telescopes now under development, it is essential to develop fast and efficient algorithms that can identify bad sensors so that they can be removed from the control loop. Such algorithms are nontrivial; for example, a simple residual-to-the-fit test will often fail to identify a bad sensor. We propose an algorithm that can reliably identify a single bad sensor and we extend it to the more difficult case of multiple bad sensors. Somewhat surprisingly, the identification of a fixed number of bad sensors does not necessarily become more difficult as the telescope becomes larger and the number of sensors in the control system increases.

Wind loads on ground-based telescopes.

One of the factors that can influence the performance of large optical telescopes is the vibration of the telescope structure due to unsteady wind inside the telescope enclosure. Estimating the resulting degradation in image quality has been difficult because of the relatively poor understanding of the flow characteristics. Significant progress has recently been made, informed by measurements in existing observatories, wind-tunnel tests, and computational fluid dynamic analyses. We combine the information from these sources to summarize the relevant wind characteristics and enable a model of the dynamic wind loads on a telescope structure within an enclosure. The amplitude, temporal spectrum, and spatial distribution of wind disturbances are defined as a function of relevant design parameters, providing a significant improvement in our understanding of an important design issue.

Control and alignment of segmented-mirror telescopes: matrices, modes, and error propagation.

Starting from the successful Keck telescope design, we construct and analyze the control matrix for the active control system of the primary mirror of a generalized segmented-mirror telescope, with up to 1000 segments and including an alternative sensor geometry to the one used at Keck. In particular we examine the noise propagation of the matrix and its consequences for both seeing-limited and diffraction-limited observations. The associated problem of optical alignment of such a primary mirror is also analyzed in terms of the distinct but related matrices that govern this latter problem.