Neuroprotective effects of niosomes loaded with thymoquinone in the cerebral ischemia model of male Wistar rats.

The complex stroke pathophysiology, like oxidative stress and inflammatory reactions, causes substantially challenged in stroke treatment. Thymoquinone (TQ) is attributed to pharmacological actions like antioxidant and anti-inflammation. Thymoquinone is chemically hydrophobic, which causes poor solubility and bioavailability. To overcome this challenge Thymoquinone niosome was applied in this in-vivo study. The results demonstrated a significant reduction in rats treated with Thymoquinone niosome compared to free Thymoquinone and control groups (SOD), (TAC), and (GPX) activities were increased in the TQN group compared to the MCAO control group. The decrease in (MDA) level was seen in the Thymoquinone niosome group compared to the MCAO control group. The inflammation factors expression rates of IL-IB, IL-6, TNFα in I/R Thymoquinone niosome group were decreased. This study indicated that Thymoquinone niosome might be utilized as a promising novel carrier to improve Thymoquinone bioavailability and therapeutic effect in treating cerebral I/R injury.

Comment on "Quantum fidelity approach to the ground-state properties of the one-dimensional axial next-nearest-neighbor Ising model in a transverse field".

Here we show that, although quantum fidelity can truly identify two quantum phase transitions of a one-dimensional spin-1/2 quantum Ising model with competing nearest and next-nearest neighbor interactions in a transverse magnetic field, it may not be a suitable approach for analyzing its ground-state phase diagram.

Ultrasonographic findings of masseter muscle in females with temporomandibular disorders.

OBJECTIVES: The aim of this study was to evaluate of ultrasonographic findings of masseter muscle in females with temporomandibular disorders. Sonographic features were compared in those with myofacial pain disorder (MPD) and temporomandibular click, as well as healthy women. METHODS: Sixty-three females referred to the Prosthetic Department of Dental Faculty of Mashhad University of Medical Sciences (22 with MPD, 21 with click, and 20 control subjects) aged from 20 to 40 years were evaluated. The masseter muscle thickness in each group was measured bilaterally at rest and maximum contraction by a real-time ultrasound imaging technique. The type of the internal pattern of the masseter muscle in sonography was classified to 3 types (I, II, and III) according to the visibility, widths, and echogenicity of internal echogenic bands. RESULTS: In the right-side masseter, thickness in the control group was greater than that in the MPD group (P = 0.033). There was no significant difference about the thickness of the masseter at rest and at maximum contraction between both sides in control and MPD groups; however, in the click group, the difference was significant. Also, the muscle thickness of either right or left side at rest and at maximum contraction was significant. There was a significant difference between control and MPD groups (P < 0.001) as well as MPD and click groups (P < 0.001) in the type of the internal pattern. CONCLUSIONS: There were obvious ultrasonographic changes of the masseter muscle in females with MPD, which might be related to the muscle inflammation.

Odontogenic keratocysts in Nevoid basal cell carcinoma syndrome: a case report.

Nevoid basal cell carcinoma syndrome, a rare autosomal dominant disorder, comprises a number of abnormalities such as multiple nevoid basal cell carcinomas, skeletal abnormalities and multiple odontogenic keratocysts. Considering the rarity of this syndrome, we present a 12-year-old boy affected by this syndrome. He had multiple okcs, calcification of falx cerebri, bifid ribs, frontal bossing and hypertelorism. Characteristic cutaneous manifestation (nevoid basal cell carcinoma) was not present in this patient. The jaw cysts were treated with marsupialization then enucleation. The dental clinician may be the first to encounter and identify this syndrome, when the multiple cystlike radiolucencies are discovered on panoramic view.