[Effect of anticholinesterase preparations on the conduction of nociceptive excitation in the spinal cord]. / Vliianie antikholinésteraznykh preparatov na provedenie notsitseptivnogo vozbuzhdeniia v spinnom mozge.

The effect of anticholinesterases physostigmine and galanthamine on spontaneous and intraarterial bradykinin-induced bioelectrical activity in the ventrolateral tracts of the spinal cord in spinal rats was studied. Physostigmine (1, 2 and 4 micrograms) and galanthamine (25, 50 and 100 micrograms) administered intrathecally were found to produce dose-dependent inhibition both of spontaneous and induced bioelectrical activity. Atropine (1 mg/kg, intravenously) abolished the inhibitory effect of anticholinesterases.

[Study of magnet-controlled transport of curare-like preparations of diadonium and dipyronium in animal experiments]. / Izuchenie magnitoupravliaemogo transporta kurarepodobnykh preparatov diadoniia i dipironiia v éksperimentakh na zhivotnykh.

The experiments on cats have shown that liposomes containing ferrocolloid and neuromuscular blocking agents (diadonium or dipyronium) cause selective muscle relaxation in the animal limb placed into the magnetic field, compared to the control limb kept outside the field. This effect was not related to the action of the magnetic field per se on neuromuscular transmission or the potency of neuromuscular blocking agents not contained in liposomes, but was induced by the accumulation of magnet-controlled liposomes in the target limb. The use of magnet-controlled liposomes for diadonium and dipyronium transport to one of the animal limbs decreases their unfavourable effect on respiratory muscle function.

[Effect of M-cholinomimetics on nociceptive stimulation in the spinal cord]. / Vliianie M-kholinomimetikov na provedenie notsitseptivnogo vozbuzhdeniia v spinnom mozge.

Two series of experiments were performed to study the effects of oxotremorine (5, 10 and 20 micrograms/kg), arecoline (0.25, 0.5 and 1.0 mg/kg), pilocarpine (5, 10 and 20 mg/kg) and aceclidine (0.25, 0.5 and 1.0 mg/kg) injected intravenously on nociceptive transmission in the spinal cord of spinal rats. It was established that the m-cholinomimetics inhibit in a dose-dependent manner the nociceptive reflex induced by intraarterial injection of bradykinin. When given in the same doses the drugs reduce the bradykinin-induced bioelectrical activity in the afferent tracts of the spinal cord. Atropine (1 mg/kg i. v.) abolishes the antinociceptive action of the cholinomimetics.

[Use of a magnetic field for guided transport of curare-like substances]. / Ispol'zovanie magnitnogo polia dlia napravlennogo deistviia kurarepodobnykh sredstv.

Magnetically carried microspheres were used to investigate whether the curare-like drugs can be selectively transported to the muscles of one of the limbs of the cat. Pyrocurine and diadonium incorporated in such microspheres primarily suppressed neuromuscular transmission in the limb placed in magnetic field as compared with the control placed outside the field. The use of magnetic microspheres cointaining pyrocurine and diadonium produced no changes in systemic arterial blood pressure, local blood flow, EEG or ECG. The method also diminished the respiratory depression produced by the curare-like substances when they are routinely used for body muscle relaxation.

[Effect of droperidol, aminazine and diazepam on the analgesic activity of leucine-enkephalin]. / Vliianie droperidol, aminazina i diazepama na anal'geticheskuiu aktivnost' leitsin-énkefalina.

In experiments on rats it was shown that the neuroleptics droperidol (0.6 mg/kg) and aminazin (10 mg/kg) can potentiate the analgetic action of the endogenous morphine-like pentapeptide leucin-enkephalin administered into the brain ventricles at a dose of 50 micrograms. A statistically significant increase in the analgetic activity lf leucin-enkephalin given at a dose of 100 micrograms was induced only by droperidol. The tranquilizer diazepam (5 mg/kg) had no effect on the action lf leucin-enkephalin. Naloxon (2 mg/kg) removed the analgetic effect of leuchin-enkephalin administered both alone and after a preliminary injection od droperidol or aminazin.