ABSTRACT
We assessed the lifetime prevalence and morbid risk of psychoactive substance use disorder (SUD; alcoholism and drug use disorder) in the first- and second-degree relatives, excluding children, of 34 female patients with anorexia nervosa (AN) and 34 age- and sex-matched controls who had no history of an eating disorder. Diagnoses of relatives were made blind to probands' diagnoses. The prevalence of SUD was 9% in both anorectic and control relatives, and the figures for morbid risk were 14% and 15%, respectively; these differences were nonsignificant. These results suggest that adolescent and adult women with AN do not possess many of the familial factors that predispose to the development of psychoactive SUD.
Subject(s)
Anorexia Nervosa/genetics , Psychotropic Drugs , Substance-Related Disorders/genetics , Adolescent , Adult , Alcoholism/diagnosis , Alcoholism/genetics , Alcoholism/psychology , Anorexia Nervosa/diagnosis , Anorexia Nervosa/psychology , Bulimia/diagnosis , Bulimia/genetics , Bulimia/psychology , Depressive Disorder/diagnosis , Depressive Disorder/genetics , Depressive Disorder/psychology , Female , Humans , Substance-Related Disorders/diagnosis , Substance-Related Disorders/psychologyABSTRACT
The authors determined the lifetime prevalence of affective disorder in the first- and second-degree relatives, excluding children, of 27 bulimic women who had never had anorexia nervosa and 27 women with no history of an eating disorder. Family diagnoses were made blind to the proband's diagnosis. The prevalence of affective disorder was 9% in the relatives of the bulimic probands and 10% in the relatives of the control probands, a nonsignificant difference. These findings are in contrast to reports of an increased prevalence of affective disorder in the relatives of patients with anorexia nervosa.
