Subject(s)
Decamethonium Compounds/administration & dosage , Formaldehyde/administration & dosage , Maxillary Sinus/drug effects , Penicillins/administration & dosage , Sinusitis/drug therapy , Acute Disease , Adolescent , Adult , Child , Chronic Disease , Drug Evaluation , Female , Humans , Male , Middle Aged , SolutionsABSTRACT
Biological properties and sensitivity to antibiotics and decametoxin of 464 strains of Ps. aeruginosa isolated at Pedigree Cattle Stations in the Chernovitsy region were studied in vitro. The isolates proved to be resistant to penicillin. Decametoxin, a new antimicrobial drug was at the same level as neomycin by its effect on Ps. aeruginosa (bactericidal concentrations of 62.5 to 125 gamma/ml). Gentamycin prepared in the USSR was approximately 20 times more active against Ps. aeruginosa than decametoxin and neomycin.
Subject(s)
Cattle/microbiology , Pseudomonas aeruginosa/isolation & purification , Animals , Anti-Bacterial Agents/pharmacology , Male , Microbial Sensitivity Tests , Mucus/microbiology , Penis/microbiology , Pseudomonas aeruginosa/drug effects , Pseudomonas aeruginosa/pathogenicity , Semen/microbiology , UkraineABSTRACT
The results of the study of the detoxicating effect of decamethoxin on diphtheria toxin are presented. It was noted that decamethoxin in subbacteriostatic concentrations inhibited the process of the toxin production in Corynebacteria diphtheriae. The detoxicating effect of the drug was clearly evident when used in a concentration of 10gamma/ml at a 2-hour exposure. Decamethoxin in a dose of 0.1 gamma/ml neutralized the effect of the diphtheria toxin on contact for 24 hours.
Subject(s)
Decamethonium Compounds/pharmacology , Diphtheria Toxin/pharmacology , Animals , Corynebacterium diphtheriae/drug effects , Corynebacterium diphtheriae/metabolism , Corynebacterium diphtheriae/pathogenicity , Culture Media , Depression, Chemical , Diphtheria Toxin/biosynthesis , Dose-Response Relationship, Drug , Drug Interactions , Guinea Pigs , Microbial Sensitivity Tests , RabbitsABSTRACT
Biological properties and sensitivity of 6 Corynebacteria strains to 9 antibiotics were studied in vitro. The rate of the development of resistance to neomycin, levomycetin, decamine and decamethoxin in the diphtheria causative agents was determined. Biological properties of the decamethoxin resistant variants of the diphtheria causative agents were investigated: 100 passages on media with increasing amounts of the drug. The rate of the development of resistance to decamethoxin was slower than that to neomycin, levomycetin and decamine. Changes in the biological properties and antibiotic sensitivity of the decamethoxin-adapted strains were revealed.
