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J Colloid Interface Sci ; 526: 135-144, 2018 Sep 15.
Article in English | MEDLINE | ID: mdl-29729965

ABSTRACT

The goal of this investigation was the development of smart plurifunctional polymeric particles able to deliver a biocide following an acidic trigger due to the presence of microorganisms. Such particles were synthesized by Ring-Opening Metathesis Polymerization of an α-norbornenyl polyglycidol macromonomer functionalized with biocide through a pH-sensitive imine bond. H. resinae was selected as a target strain. In the first part, the pH sensitivity of the functionalized particles was studied. Then, the antifungal activity of both the biocide-functionalized macromonomer and the functionalized particles was evaluated. Incorporation of the particles in a commercial model coating was also tested, to verify that its original barrier properties were maintained.


Subject(s)
Antifungal Agents , Ascomycota/growth & development , Nanoparticles/chemistry , Propylene Glycols , Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Delayed-Action Preparations/chemistry , Delayed-Action Preparations/pharmacology , Hydrogen-Ion Concentration , Propylene Glycols/chemistry , Propylene Glycols/pharmacology
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