CriPAV: Street-Level Crime Patterns Analysis and Visualization.

Extracting and analyzing crime patterns in big cities is a challenging spatiotemporal problem. The hardness of the problem is linked to two main factors, the sparse nature of the crime activity and its spread in large spatial areas. Sparseness hampers most time series (crime time series) comparison methods from working properly, while the handling of large urban areas tends to render the computational costs of such methods impractical. Visualizing different patterns hidden in crime time series data is another issue in this context, mainly due to the number of patterns that can show up in the time series analysis. In this article, we present a new methodology to deal with the issues above, enabling the analysis of spatiotemporal crime patterns in a street-level of detail. Our approach is made up of two main components designed to handle the spatial sparsity and spreading of crimes in large areas of the city. The first component relies on a stochastic mechanism from which one can visually analyze probable×intensive crime hotspots. Such analysis reveals important patterns that can not be observed in the typical intensity-based hotspot visualization. The second component builds upon a deep learning mechanism to embed crime time series in Cartesian space. From the embedding, one can identify spatial locations where the crime time series have similar behavior. The two components have been integrated into a web-based analytical tool called CriPAV (Crime Pattern Analysis and Visualization), which enables global as well as a street-level view of crime patterns. Developed in close collaboration with domain experts, CriPAV has been validated through a set of case studies with real crime data in São Paulo - Brazil. The provided experiments and case studies reveal the effectiveness of CriPAV in identifying patterns such as locations where crimes are not intense but highly probable to occur as well as locations that are far apart from each other but bear similar crime patterns.

Viral surveillance: Governing social isolation in São Paulo, Brazil, during the COVID-19 Pandemic.

In the context of COVID-19 pandemics, Brazilian cities implemented social isolation policies and deployed digital systems to monitor urban mobility. This article addresses the setting of two digital technologies based on massive cell-phone data collection by private companies in São Paulo state. We relied on secondary data from multiple sources (press conferences, interviews, newspaper articles, public documents), complemented by primary data from the authors' ongoing research. In our analysis of heterogeneous and contingent techniques of pandemic control, we found that although these monitoring technologies seem to be effective in assisting public services and informing society, they also raise issues about performativity and transparency, with relevant consequences for their adoption in sanitary emergencies, and their potential legacy to São Paulo's public safety management.

CrimAnalyzer: Understanding Crime Patterns in São Paulo.

São Paulo is the largest city in South America, with crime rates that reflect its size. The number and type of crimes vary considerably around the city, assuming different patterns depending on urban and social characteristics of each particular location. Previous works have mostly focused on the analysis of crimes with the intent of uncovering patterns associated to social factors, seasonality, and urban routine activities. Therefore, those studies and tools are more global in the sense that they are not designed to investigate specific regions of the city such as particular neighborhoods, avenues, or public areas. Tools able to explore specific locations of the city are essential for domain experts to accomplish their analysis in a bottom-up fashion, revealing how urban features related to mobility, passersby behavior, and presence of public infrastructures (e.g., terminals of public transportation and schools) can influence the quantity and type of crimes. In this paper, we present CrimAnalyzer, a visual analytic tool that allows users to study the behavior of crimes in specific regions of a city. The system allows users to identify local hotspots and the pattern of crimes associated to them, while still showing how hotspots and corresponding crime patterns change over time. CrimAnalyzer has been developed from the needs of a team of experts in criminology and deals with three major challenges: i) flexibility to explore local regions and understand their crime patterns, ii) identification of spatial crime hotspots that might not be the most prevalent ones in terms of the number of crimes but that are important enough to be investigated, and iii) understand the dynamic of crime patterns over time. The effectiveness and usefulness of the proposed system are demonstrated by qualitative and quantitative comparisons as well as by case studies run by domain experts involving real data. The experiments show the capability of CrimAnalyzer in identifying crime-related phenomena.

Praziquantel-Solid Lipid Nanoparticles Produced by Supercritical Carbon Dioxide Extraction: Physicochemical Characterization, Release Profile, and Cytotoxicity.

Solid lipid nanoparticles (SLNs) can be produced by various methods, but most of them are difficult to scale up. Supercritical fluid (SCF) is an important tool to produce micro/nanoparticles with a narrow size distribution and high encapsulation efficiency. The aim of this work was to produce cetyl palmitate SLNs using SCF to be loaded with praziquantel (PZQ) as an insoluble model drug. The mean particle size (nm), polydispersity index (PdI), zeta potential, and encapsulation efficiency (EE) were determined on the freshly prepared samples, which were also subject of Differential Scanning Calorimetry (DSC), Fourier-Transform Infrared Spectroscopy (FTIR), drug release profile, and in vitro cytotoxicity analyses. PZQ-SLN exhibited a mean size of ~25 nm, PdI ~ 0.5, zeta potential ~-28 mV, and EE 88.37%. The DSC analysis demonstrated that SCF reduced the crystallinity of cetyl palmitate and favored the loading of PZQ into the lipid matrices. No chemical interaction between the PZQ and cetyl palmitate was revealed by FTIR analysis, while the release or PZQ from SLN followed the Weibull model. PZQ-SLN showed low cytotoxicity against fibroblasts cell lines. This study demonstrates that SCF may be a suitable scale-up procedure for the production of SLN, which have shown to be an appropriate carrier for PZQ.

Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(ε-caprolactone) Nanocapsules.

The objective of this work was to characterize the toxicological profile of a newly developed sunscreen formulation based on polymeric nanocapsules (NCs) loading benzophenone-3 (BZP3). NCs composed of poly(ε-caprolactone) carrot oil and Pluronic® F68 were produced by emulsification-diffusion method. Their mean particle size (Z-Ave) ranged from 280 to 420 nm, polydispersity index (PDI) was below 0.37, while zeta potential (ZP) reached about |+11 mV|. No cytotoxic effects were observed in L929 fibroblast cell line for the blank (i.e., non-loaded) NCs and BZP3-loaded NCs (BZP3-NCs). The semi-solid sunscreen formulation was stable over time (centrifugation testing) and exhibited non-Newtonian pseudoplastic behavior, which is typical of products for topical application onto the skin. The sun protection factor (SPF) value reached 8.84, when incorporating BZP3-NCs (SPF of 8.64) into the semi-solid formulation. A synergistic effect was also observed when combining the formulation ingredients of nanocapsules, i.e., SPF of carrot oil was 6.82, blank NCs was 6.84, and BZP3-loaded NCs was 8.64. From the hen's egg-chorioallantoic membrane test (HET-CAM) test, the non-irritation profile of the developed formulations could also be confirmed. The obtained results show a promising use of poly(ε-caprolactone) nanocapsules to be loaded with lipophilic sunscreens as benzophenone-3.

Evolução dos homicídios e indicadores de segurança pública no Município de São Paulo entre 1996 a 2008: um estudo ecológico de séries temporais / Homicide and public security indicator trends in the city of São Paulo between 1996 and 2008: a time-series ecological study

OBJETIVO: analisar a associação entre homicídios e indicadores de segurança pública no MSP entre 1996 e 2008, após controle para taxa de desemprego e proporção de jovens na população. METODOLOGIA: estudo ecológico de série temporal, tendo como unidade de análise o Município de São Paulo (MSP), entre 1996 e 2008. Variável dependente: óbitos por homicídio; variáveis independentes principais: taxa de aprisionamento-encarceramento (TAE), o acesso a armas de fogo (AAF), e a atividade policial (ATP). A análise dos dados foi realizada com o software Stata.IC 10.0. Modelos de regressão binomial negativa simples e multivariados foram construídos. RESULTADOS: A análise univariada demonstrou associação entre óbitos por homicídio e TAE e entre óbitos e ATP. O AAF não se mostrou associado à redução no número de óbitos por homicídios (p > 0,05). Após ajuste houve perda da significância na associação com ambos indicadores de Segurança Pública. CONCLUSÕES: No MSP o papel das ações de segurança pública perdem importância como fatores explicativos para a redução nos níveis de homicídios após controle para taxa de desemprego e redução na proporção de jovens. Os resultados reforçam a importância dos fatores socioeconômicos e demográficos para a mudança no cenário da segurança em São Paulo.

The scope of this paper was to analyze the association between homicides and public security indicators in São Paulo between 1996 and 2008, after monitoring the unemployment rate and the proportion of youths in the population. A time-series ecological study for 1996 and 2008 was conducted with São Paulo as the unit of analysis. Dependent variable: number of deaths by homicide per year. Main independent variables: arrest-incarceration rate, access to firearms, police activity. Data analysis was conducted using Stata.IC 10.0 software. Simple and multivariate negative binomial regression models were created. Deaths by homicide and arrest-incarceration, as well as police activity were significantly associated in simple regression analysis. Access to firearms was not significantly associated to the reduction in the number of deaths by homicide (p>0,05). After adjustment, the associations with both the public security indicators were not significant. In São Paulo the role of public security indicators are less important as explanatory factors for a reduction in homicide rates, after adjustment for unemployment rate and a reduction in the proportion of youths. The results reinforce the importance of socioeconomic and demographic factors for a change in the public security scenario in São Paulo .

Regimes espaciais: dinâmica dos homicídios dolosos na cidade de São Paulo entre 2000 e 2008 / Spatial regimes: dynamics of intentional homicides in the city of São Paulo between 2000 and 2008

OBJETIVO: Identificar a existência de padrões espaço-temporais na ocorrência de homicídios dolosos no Município de São Paulo (MSP) e discutir o valor analítico de levar em conta tais padrões ao elaborar estudos que tratam da dinâmica e dos fatores associados à incidência dos homicídios dolosos. MÉTODOS: Realizou-se um estudo ecológico e longitudinal, tendo como unidades de análise 13 205 setores censitários e os 96 distritos censitários que congregam esses setores na capital paulista. Foram estudados todos os homicídios dolosos registrados no município entre 2000 e 2008 e calculadas as taxas brutas de homicídios dolosos por 100 000 habitantes para cada setor censitário, assim como as taxas bayesianas globais e locais. Para verificar a possibilidade de identificar diferentes padrões de distribuição espacial dos homicídios, foram utilizadas as técnicas BoxMap e o índice de Moran. RESULTADOS: Não houve uma tendência homogênea e sistemática dos homicídios ao longo da última década na capital paulista. Ao invés disso, foram identificados sete padrões de distribuição espacial, ou seja, sete regimes espaciais, para a ocorrência de homicídios dolosos, considerando as taxas dentro de cada setor censitário e nos setores adjacentes. Esses regimes de distribuição espacial não estavam contidos nos limites dos setores e distritos censitários do município. CONCLUSÕES: Os resultados mostraram a importância de analisar a distribuição espacial dos fenômenos sociais sem restrição de fronteiras político-administrativas.

OBJECTIVE: To identify the existence of spatial and temporal patterns in the occurrence of intentional homicides in the municipality of São Paulo (MSP), Brazil, and to discuss the analytical value of taking such patterns into account when designing studies that address the dynamics and factors associated with the incidence of homicides. METHODS: A longitudinal ecological study was conducted, having as units of analysis 13 205 census tracts and the 96 census districts that congregate these sectors in São Paulo. All intentional homicides reported in the city between 2000 and 2008 were analyzed. The gross homicide rates per 100 000 population was calculated as well as the global and local Bayesian estimates for each census tract during the study period. To verify the possibility of identifying different patterns of the spatial distribution of homicides, we used BoxMap and Moran's I index. RESULTS: The homicide trends in the city of São Paulo in the last decade were not homogeneous and systematic. Instead, seven patterns of spatial distribution were identified; that is, seven spatial regimes for the occurrence of intentional homicides, considering the homicide rates within each census tract as well as the rates in adjacent tracts. These spatial distribution regimes were not contained within the limits of the census tracts and districts. CONCLUSIONS: The results show the importance of analyzing the spatial distribution of social phenomena without restriction of political and administrative boundaries.

[Homicide and public security indicator trends in the city of São Paulo between 1996 and 2008: a time-series ecological study]. / Evolução dos homicídios e indicadores de segurança pública no Município de São Paulo entre 1996 a 2008: um estudo ecológico de séries temporais.

The scope of this paper was to analyze the association between homicides and public security indicators in São Paulo between 1996 and 2008, after monitoring the unemployment rate and the proportion of youths in the population. A time-series ecological study for 1996 and 2008 was conducted with São Paulo as the unit of analysis. Dependent variable: number of deaths by homicide per year. Main independent variables: arrest-incarceration rate, access to firearms, police activity. Data analysis was conducted using Stata.IC 10.0 software. Simple and multivariate negative binomial regression models were created. Deaths by homicide and arrest-incarceration, as well as police activity were significantly associated in simple regression analysis. Access to firearms was not significantly associated to the reduction in the number of deaths by homicide (p>0,05). After adjustment, the associations with both the public security indicators were not significant. In São Paulo the role of public security indicators are less important as explanatory factors for a reduction in homicide rates, after adjustment for unemployment rate and a reduction in the proportion of youths. The results reinforce the importance of socioeconomic and demographic factors for a change in the public security scenario in São Paulo .

[Spatial regimes: dynamics of intentional homicides in the city of São Paulo between 2000 and 2008]. / Regimes espaciais: dinâmica dos homicídios dolosos na cidade de São Paulo entre 2000 e 2008.

OBJECTIVE: To identify the existence of spatial and temporal patterns in the occurrence of intentional homicides in the municipality of São Paulo (MSP), Brazil, and to discuss the analytical value of taking such patterns into account when designing studies that address the dynamics and factors associated with the incidence of homicides. METHODS: A longitudinal ecological study was conducted, having as units of analysis 13 205 census tracts and the 96 census districts that congregate these sectors in São Paulo. All intentional homicides reported in the city between 2000 and 2008 were analyzed. The gross homicide rates per 100 000 population was calculated as well as the global and local Bayesian estimates for each census tract during the study period. To verify the possibility of identifying different patterns of the spatial distribution of homicides, we used BoxMap and Moran's I index. RESULTS: The homicide trends in the city of São Paulo in the last decade were not homogeneous and systematic. Instead, seven patterns of spatial distribution were identified; that is, seven spatial regimes for the occurrence of intentional homicides, considering the homicide rates within each census tract as well as the rates in adjacent tracts. These spatial distribution regimes were not contained within the limits of the census tracts and districts. CONCLUSIONS: The results show the importance of analyzing the spatial distribution of social phenomena without restriction of political and administrative boundaries.

[Decline in homicide rates in São Paulo, Brasil: a descriptive analysis]. / Queda dos homicídios em São Paulo, Brasil: uma análise descritiva.

OBJECTIVE: To describe homicide mortality in the municipality of São Paulo according to type of weapon, sex, race or skin color, age, and areas of socioeconomic inequalities, between 1996 and 2008. METHOD: For this ecological time-series study, data about deaths in the municipality of São Paulo were collected from the municipal program for improvement of mortality information, using International Classification of Diseases, 10th revision (ICD-10) codes. Homicide mortality rates (HMR) were calculated for the overall population and specifically for each sex, race or skin color, age range, type of weapon, and occurrence in social deprivation/affluence areas. HMR were adjusted for age using the direct method. The percentage age of variation in HMR was calculated for the study period. For areas of socioeconomic inequalities, the relative risk of death from homicide was calculated. RESULTS: HMR fell 73.7% between 2001 and 2008. A reduction in HMR was observed in all groups, especially males (-74.5%), young men between 15 and 24 years of age (-78.0%), and residents in areas of extreme socioeconomic deprivation (-79.3%). The reduction occurred mostly in firearm homicide rates (-74.1%). The relative risk of death from homicide in areas of extreme socioeconomic deprivation, as compared to areas with some degree of socioeconomic deprivation, was 2.77 in 1996, 3.9 in 2001, and 2.13 in 2008. In areas of high socioeconomic deprivation, the relative risk was 2.07 in 1996 and 1.96 in 2008. CONCLUSIONS: To understand the reduction in homicide rates in the municipality of São Paulo, it is important to take into consideration macrodeterminants that affect the entire municipality and all population subgroups, as well as micro/local determinants that have special impact on homicides committed with firearms and on subgroups such as the young, males, and residents of areas of high socioeconomic deprivation.

Queda dos homicídios em São Paulo, Brasil: uma análise descritiva / Decline in homicide rates in São Paulo, Brasil: a descriptive analysis

OBJETIVO: Descrever a evolução da mortalidade por homicídios no Município de São Paulo segundo tipo de arma, sexo, raça ou cor, idade e áreas de exclusão/inclusão social entre 1996 e 2008. MÉTODOS: Estudo ecológico de série temporal. Os dados sobre óbitos ocorridos no Município foram coletados da base de dados do Programa de Aprimoramento das Informações sobre Mortalidade, seguindo a Classificação Internacional de Doenças, Décima Revisão (CID-10). Foram calculadas as taxas de mortalidade por homicídio (TMH) para a população total, por sexo, raça ou cor, faixa etária, tipo de arma e área de exclusão/inclusão social. As TMH foram padronizadas por idade pelo método direto. Foram calculados os percentuais de variação no período estudado. Para as áreas de exclusão/inclusão social foram calculados os riscos relativos de morte por homicídio. RESULTADOS: As TMH apresentaram queda de 73,7 por cento entre 2001 e 2008. Foi observada redução da TMH em todos os grupos analisados, mais pronunciada em homens (-74,5 por cento), jovens de 15 a 24 anos (-78,0 por cento) e moradores de áreas de exclusão social extrema (-79,3 por cento). A redução ocorreu, sobretudo, nos homicídios cometidos com armas de fogo (-74,1 por cento). O risco relativo de morte por homicídio nas áreas de exclusão extrema (tendo como referência áreas com algum grau de exclusão social) foi de 2,77 em 1996, 3,9 em 2001 e 2,13 em 2008. Nas áreas de alta exclusão social, o risco relativo foi de 2,07 em 1996 e 1,96 em 2008. CONCLUSÕES: Para compreender a redução dos homicídios no Município, é importante considerar macrodeterminantes que atingem todo o Município e todos os subgrupos populacionais e microdeterminantes que atuam localmente, influenciando de forma diferenciada os homicídios com armas de fogo e os homicídios na população jovem, no sexo masculino e em residentes em áreas de alta exclusão social.

OBJECTIVE: To describe homicide mortality in the municipality of São Paulo according to type of weapon, sex, race or skin color, age, and areas of socioeconomic inequalities, between 1996 and 2008. METHOD: For this ecological time-series study, data about deaths in the municipality of São Paulo were collected from the municipal program for improvement of mortality information, using International Classification of Diseases, 10th revision (ICD-10) codes. Homicide mortality rates (HMR) were calculated for the overall population and specifically for each sex, race or skin color, age range, type of weapon, and occurrence in social deprivation/affluence areas. HMR were adjusted for age using the direct method. The percentage age of variation in HMR was calculated for the study period. For areas of socioeconomic inequalities, the relative risk of death from homicide was calculated. RESULTS: HMR fell 73.7 percent between 2001 and 2008. A reduction in HMR was observed in all groups, especially males (-74.5 percent), young men between 15 and 24 years of age (-78.0 percent), and residents in areas of extreme socioeconomic deprivation (-79.3 percent). The reduction occurred mostly in firearm homicide rates (-74.1 percent). The relative risk of death from homicide in areas of extreme socioeconomic deprivation, as compared to areas with some degree of socioeconomic deprivation, was 2.77 in 1996, 3.9 in 2001, and 2.13 in 2008. In areas of high socioeconomic deprivation, the relative risk was 2.07 in 1996 and 1.96 in 2008. CONCLUSIONS: To understand the reduction in homicide rates in the municipality of São Paulo, it is important to take into consideration macrodeterminants that affect the entire municipality and all population subgroups, as well as micro/local determinants that have special impact on homicides committed with firearms and on subgroups such as the young, males, and residents of areas of high socioeconomic deprivation.

Litíase biliar no paciente idoso / Bile duct stone in the elderly

Os autores buscam com esta revisäo bibliográfica, uma atualizaçäo da fisiopatologia e terapêutica da litías biliar, especificamente no paciente idoso