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Bioorg Med Chem
; 12(5): 1151-75, 2004 Mar 01.
Article
in English
| MEDLINE
| ID: mdl-14980627
ABSTRACT
A series of 3-mercapto-propionic acid derivatives that function as reversible inhibitors of carboxypeptidase U have been prepared. We present a successful design strategy using cyclic, low basicity guanidine mimetics resulting in potent, selective and bioavailable inhibitors of carboxypeptidase U (TAFIa).