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J Perinatol ; 31 Suppl 1: S57-60, 2011 Apr.
Article in English | MEDLINE | ID: mdl-21448206

ABSTRACT

Parenteral nutrition (PN), containing fat emulsions derived from soybean, has been implicated in the progression of PN-associated liver disease and cholestasis, particularly in infants with short bowel syndrome. Clinical use of Omegaven, a parenteral fish-oil emulsion, has been shown in recent studies to be a promising therapy to reverse liver disease and cholestasis. This review summarizes the rationale, relevant clinical investigations and future direction of Omegaven therapy for PN-dependent infants.


Subject(s)
Fat Emulsions, Intravenous , Fatty Acids, Omega-3/administration & dosage , Liver Diseases/etiology , Liver Diseases/therapy , Parenteral Nutrition/adverse effects , Cholestasis/etiology , Cholestasis/therapy , Humans , Infant , Infant, Newborn , Short Bowel Syndrome/therapy
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