ABSTRACT
The serum and cerebrospinal fluid (CSF) from patients with epilepsy resultant from cerebral leptomeningitis in the fit-free intervals were examined for some hypophyseal and adrenal hormones with reference to the disease course, severity and duration, frequency of the seizures. The levels of hydrocortisone, aldosterone and STH were found stable, while those of prolactin got elevated, especially in males. Hormonal shifts in the serum and CSF appeared significantly different. STH lowered, but prolactin went up only in CSF. The latter increase was related to the seizures frequency.
Subject(s)
Adrenal Cortex Hormones/analysis , Epilepsy, Generalized/metabolism , Pituitary Hormones/analysis , Adolescent , Adult , Animals , Brain Chemistry/drug effects , Cerebrospinal Fluid/physiology , Epilepsy, Generalized/etiology , Female , Humans , Male , Meningitis/complications , Meningitis/metabolism , Middle Aged , Osteochondritis/metabolism , Rats , Spondylitis/metabolismABSTRACT
The prolactin concentration in blood of 58 patients was measured during vestibular crisis and compensation of vestibular disorders. The results were compared with the clinical development of the disease and localization of vestibular problems. Patients with acute vestibular lesions at the central level of vestibular disorders showed a significant increase of prolactin concentrations that was higher than the concentrations in patients with the peripheral vestibular syndrome at the decompensation stage. Hyperprolactinemia during central vestibular dysfunction is viewed as a manifestation of dopamine deficiency of the tuberoinfundibular area. It is suggested that inadequacy of dopaminergic structures is one of the factors reducing adaptive and compensatory capabilities of the vestibular apparatus when its central compartments are injured.