ABSTRACT
AIM: Monitoring of post-vaccinal complications in children immunized with a parotitis vaccine. MATERIALS AND METHODS: Observation of 198 945 children, immunized with 16 lots of parotitis vaccine with Leningrad-3 strain (L-3), was carried out for 3 years. Paired samples of sera and saliva were obtained from children, in whom adverse events were registered for 42 days after vaccination. Titers of specific IgM and IgG were determined in blood sera. Analysis of nucleotide sequences of genes F, SH and NH of RNA of parotitis virus was carried out from samples of blood and saliva. RESULTS: Intensive parameter of vaccine-associated aseptic meningitis under the conditions of the experiments was 0 for 100 000 immunized. Frequency of occurrence of post-vaccinal parotitis was 0.06% from the number of vaccinated--18 cases of vaccine-associated parotitis were registered and laboratory confirmed. A significant difference in specific activity was detected for 3 lots of the vaccine, that were associated with cases of development of parotitis, relative to that of 13 lots of vaccine, development of parotitis was not registered after administration of those. CONCLUSION: The study carried out confirmed low neurovirulence of the parotitis vaccine with the L-3 strain of parotitis virus, as well as a low degree of its reactogenicity. A relatively high immunization dose of the used vaccine could be one of the reasons of development of post-vaccinal complications in part of the immunized children.
Subject(s)
Antibodies, Viral/blood , Parotitis/prevention & control , RNA, Viral/blood , Vaccination , Viral Vaccines/administration & dosage , Adolescent , Child , Child, Preschool , Female , Humans , Immunization Schedule , Male , Parotid Gland/immunology , Parotid Gland/pathology , Parotid Gland/virology , Parotitis/immunology , Parotitis/pathology , Parotitis/virology , Patient Safety , Russia , Saliva/immunology , Saliva/virology , Viral Vaccines/biosynthesis , Viral Vaccines/immunologyABSTRACT
Presented are the results of experimental research on 144 animals (the rats Wistar), on whom was carried out resection of a part of large intestine and a intestinal anastamosis was formed in the presents of acute intestinal obstruction and peritonitis. The sanitation of abdominal cavity in the basic group of animals (74) was performed using sodium hypochlorite solution and dissolved ozone. The intestinal lavage was carried out by dissolved ozone with the subsequent introduction of ozonized oil Ozonide in the area of intestinal anastamosis. The combined application of ozone and sodium produces an expressed samative effect which leads to healing of intestinal anastamosis and decreases unstability of intestinal sutures and mortality.
Subject(s)
Intestinal Obstruction/drug therapy , Oxidants, Photochemical/pharmacology , Ozone/pharmacology , Peritonitis/drug therapy , Sodium Hypochlorite/pharmacology , Abdominal Cavity , Acute Disease , Animals , Disease Models, Animal , Rats , Rats, Wistar , Remission InductionABSTRACT
The organized benchmark analysis result treatments 152 sick with taken in perforated gastroduodenal ulcers. In the main group (87 sick) in complex treatment are used methods of ozonotherapy. In group of the comparison (65 sick) used standard scheme of the treatment to peptic ulcer. Methods of ozonotherapy promote more early and more full recovering the structure gastroduodenal mucous and provide efficient eradication of Helicobacter pylori, reduces the time of the healing the ulcers and reduces the risk of the relapse ulcers.
