[The use of the medicine Ophtalmoferon for the treatment of conjunctivitis in patients with HIV-infection and tuberculosis]. / Opyt primeneniya preparata Oftal'moferon pri kon"yunktivitakh, assotsiirovannykh s VICh-infektsiei i tuberkulezom.

PURPOSE: To assess the effectiveness of the medicine Ophtalmoferon (eye drops) in the treatment of conjunctivitis of mixed aetiology in patients with first-time tuberculosis (TB) and human immunodeficiency virus (HIV) infection, who have been treated at the Clinical Anti-tuberculosis Hospital No. 4. MATERIAL AND METHODS: The study included 60 patients (42 men and 18 women with mean age of 41.48±1.34 years), who had consulted the ophthalmologist for conjunctivitis. The patients were divided into two groups: the first group - main one (n=32) - received complex local therapy with the medicine Ophtalmoferon; the second group (n=28) - control one - did not receive Ophtalmoferon as a part of complex local treatment. The treatment involved assessment of the effectiveness, tolerability and safety of the examined medicine. RESULTS: Patient examinations were conducted on the first visit, then on the third, fifth and seventh day of treatment. On the third day of treatment as compared to the baseline the burning sensation and pain in the eyes were less severe; in the main group that received the medicine Ophtalmoferon (group 1) the number of patients describing these symptoms as mild (1 point) were 15.6% (pain) and 18.8% (burning), respectively (W=2.15; p=0.03). Severe lacrimation (3 points) remained in 5 (15.6%) patients. On the fifth day there were no main group patients with severe (3 points) or moderate (2 points) lacrimation. On the seventh day complete resolution of subjective symptoms was noted in 71.9% (group 1) and 42.9% (group 2) of patients (χ2=1.39; p=0.238), respectively. There was no lacrimation in 71.9% (group 1) and 35.7% (group 2) of patients (χ2=2.36; p=0.125), no eye redness was noted in 78.1% (group 1) and 28.6% (group 2) of patients (χ2=4.51; p=0.034), respectively. CONCLUSION: The use of the combined medicine Ophtalmoferon in the complex local treatment of conjunctivitis of mixed aetiology in patients with tuberculosis and HIV infection helps to achieve a rapid relief of subjective and objective symptoms with good tolerability of the medicine.

[The rationale for the conservative treatment of chronic tonsillitis in the patients of the older age groups by the «soft¼ therapy methods]. / Obosnovanie konservativnogo lecheniya khronicheskogo tonzillita u lits starshikh vozrastnykh grupp metodami «myagkoi¼ terapii.

The objective of the present study was to develop an efficient system for the treatment of chronic tonsillitis in the patients of advanced and middle age based on the application of polyvalent bacteriophages in the combination with the physical factors and herbal medicines. The study involved 65 patients (39 women and 276 men) at the age from 65 to 73 years presenting with chronic tonsillitis. The treatment included washing the tonsillar lacunae with herbal infusion consisting of a tetterwort (Choledoniummajus) extract. This procedure was followed by phonophoresiswith the use of the combined polyvalent bacteriophage preparation in the non-liquid formulation during 7-10 days. The effectiveness of such treatment was evaluated based on the results of clinical examination and the analysis of the subjective feelings reported by the patients. In addition, the rosette-forming function of lymphocytes was estimated and palatine tonsil microbiotas in different patients were compared. The effectiveness of therapy was estimated at 89.2%. The positive outcome of the proposed treatment was documented in 78.6% of the cases within 6 months after the onset of therapy. It is concluded that the treatment of chronic tonsillitis with bacteriophagal preparations and herbal infusions in combination with thetraditionallow-frequency ultrasound treatment is highly efficacious (favourable outcome in 78.6% of the patients of middle and advanced age) without the use of antibiotic medications.

[The analysis of the influence of the adenoiditis treatment by different methods on the nasopharyngeal microbiocenosis in the children]. / Analiz vliianiia metoda lecheniia adenoidita na mikrobiotsenoz nosoglotki u deteĭ.

The objective of the present study was to analyze the quality of nasopharyngeal sanation during the treatment of the children presenting with exacerbations of chronic adenoiditis with the use of different methods. Another objective was to estimate the influence of individual methods on the indigenous microflora. The study has revealed the prevailing groups of microflora in the nasopharynx, nasal cavity, and palatine tonsils of 2.228 patients. The clinical examination and comparative analysis of the results of the bacteriological study of nasopharyngeal discharge involved 170 children at the mean age of 5.06±2.6 years presenting with exacerbations of chronic adenoiditis. The patients of group 1 (n=60, control group) underwent nasopharyngeal sanation by means of the low-frequency ultrasound treatment, those of group 2 (n=53) were given an oral antibiotics (amoxicillin/clavulanic acid) at an age-based dose during 7-10 days. The patients of group 3 (n=57) were treated with bacterial lysate OM-85 BV (Broncho-Vaxom) (a 3.5 mg capsule once daily in the morning hours under the fasting condition for 3 months (during 10 days of every month). The amount of anaerobic bacteria in the control cultures from the patients of group 1decreased six-fold and that of pneumococci by 3 times. In the children comprising group 2 all pathogenic species persisted despite the treatment whereas in group 3 the number of those species largely decreased whose lysates were contained in the medication. In the patients treated with Broncho-Vaxom the beneficial results of therapy 1 and 3 months after its onset were more apparent than in the children of two other groups. Moreover, this preparation did not affect the indigenous microflora.

[The effectiveness of topical antihistamine monotherapy in the patients presenting with the manifestations of seasonal allergic rhinitis]. / Éffektivnost' topicheskoĭ antigistaminnoĭ monoterapii pri manifestatsii sezonnogo allergicheskogo rinita.

The objective of the present study was to evaluate the effectiveness and safety of monotherapy with the use of allergoferon gel composed of topical recombinant human interferon-α-2ß and loratadine. A total of 105 patients at the age varying from 18 to 55 years presenting with the manifest form of seasonal allergic rhinitis were available for the examination. They were given the topical treatment in the recommended standard doses. The patients included in group 1 (n=65) were treated with allergoferon while those comprising group 3 (n=40) received mometasonefuorate (nasonex). Changes in the clinical symptoms were recorded on days 3, 7, 14, 21, and 28. The best results of the treatment were documented in the patients of group 1 on day 3 afterthe onset of therapy; this effect was attributed to the rapid beginning of the drug action that was apparent within15 minutes after the topical application of the medication. There were no significant difference between the manifestations of the symptoms on days 7 and 14 in the patients of both groups. None of the patients in group 1 refused to continue therapy up to day 28. Two patients in group 2 (5%) wished to discontinue the treatment due to side effects. It is concluded that the treatment with the allergoferon gel for the topical and external applications extends the possibilities for efficacious and safe therapy of the clinical manifestations of seasonal allergic rhinitis.

[Conservative therapy of chronic tonsillitis: comparison of different methods].

A comparative analysis was made of efficacy of chronic tonsillitis (CT) treatment with high frequency ultrasound (HFU), low frequency ultrasound (LFU) and laser. The study covered 172 CT patients aged 7 to 35 (65 males and 107 females) with CT history 5-32 years. Clinical examination included micropharyngoscopy, blood count, urine tests, microbiological investigation of tonsillar lacune lavage and nasal mucus, immunological tests, consultation of the therapist. Tonsillar prints were analysed for 40 patients. A compensated CT form was diagnosed in 58 patients, a decompensated one--in 114. The treatment efficacy was evaluated in the course of therapy and 1, 3, 6, 12 and 24 months after it. Immediate results were the best in patients treated with LFU on the palatine tonsils (73%). Patients exposed to LFU and laser showed good response in 35-37% in equal number of unsatisfactory outcomes. Repeated courses of all three therapies improved results in all the groups: good and satisfactory results were 69%, 51% and 43% for LFU, HFU, laser, respectively. Thus, LFU (Tonsillor device) is the most efficient up-to-date conservative therapy of CT which provides mechanical elimination of pathogens from the tonsils, a bactericidal effect, recovery of the barrier function.