Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
J Intraven Nurs ; 23(3): 176-80, 2000.
Article in English | MEDLINE | ID: mdl-11272975

ABSTRACT

A case is presented of cytotoxic extravasation as a result of an implantable venous port being perforated by a standard Huber needle. A patient receiving 5-fluorouracil via a dual reservoir port, implanted within the left chest wall, presented with hemoserous discharge from the right needle entry site. The left chest wall was warm to touch, erythematous, and swollen. Subcutaneous infiltration was suspected, and the infusion was ceased. A venogram was performed demonstrating significant extravasation around the left reservoir only. On port removal, inspection showed the Huber needle had penetrated the base plate on the left side. It is recommended that this complication be added as a possible sequelae of central venous port use.


Subject(s)
Antimetabolites, Antineoplastic/adverse effects , Carcinoma, Signet Ring Cell/drug therapy , Catheters, Indwelling/adverse effects , Fluorouracil/adverse effects , Stomach Neoplasms/drug therapy , Aged , Equipment Failure , Humans , Male
2.
Acta Neuropathol ; 96(5): 509-14, 1998 Nov.
Article in English | MEDLINE | ID: mdl-9829815

ABSTRACT

Autosomal recessive limb-girdle muscular dystrophies are a heterogeneous group of genetic diseases with a wide spectrum of clinical severity and age of onset; mutations in the gene encoding the dystrophin-associated sarcoglycan proteins (alpha, beta, gamma and delta) have recently been shown to cause some cases of these myopathies (primary sarcoglycanopathies, types 2D, 2E, 2C and 2F, respectively). In this study we have examined a large population of Italian myopathic patients to determine the frequency of (alpha-, beta- and gamma-sarcoglycan deficiency and to correlate molecular defects with clinical phenotypes; to exclude the presence of primary dystrophinopathies both genetic and immunological analysis of dystrophin was performed. We report 12 patients (10 male and 2 female) with deficiency of either one or more sarcoglycan proteins. They were aged 8-56 years with onset between 4 and 30 years of age; they all presented with either mild, moderate or severe limb-girdle involvement associated with elevated blood creatine kinase levels and myopathic pattern at EMG; one was also affected with a mild dilation cardiomyopathy. All patients, except one, showed pathological muscle histological changes. Absence of all three proteins always correlates with severe forms, whereas mild protein deficiencies or isolated partial alpha-sarcoglycan deficiency correlate with either severe, moderate or mild forms.


Subject(s)
Cytoskeletal Proteins/deficiency , Membrane Glycoproteins/deficiency , Muscular Diseases/metabolism , Adolescent , Adult , Child , Dystroglycans , Female , Humans , Immunoblotting , Immunohistochemistry , Italy , Male , Middle Aged , Muscle, Skeletal/metabolism , Muscle, Skeletal/pathology , Muscular Diseases/pathology , Sarcoglycans
SELECTION OF CITATIONS
SEARCH DETAIL
...