[Hypogammaglobulinemia as risk factor for Cryptococcus neoformans infection: report of 2 cases]. / Hipogamaglobulinemia como fator de risco para infecção por Cryptococcus neoformans: a propósito de dois casos.

Two HIV-seronegative patients with cryptococcal disease refractory to conventional antifungal therapy were submitted to an evaluation of the immune system. Hypogammaglobulinemia was found in both and associated with abnormal function of cell-mediated immunity. Hypogammaglobulinemia is considered as a possible predisposing factor for cryptococcal infection. The importance of the antibodies on the control of Cryptococcus neoformans infection is discussed.

[Disseminated cutaneous sporotrichosis as the initial manifestation of acquired immunodeficiency syndrome--case report]. / Esporotricose cutânea disseminada como manifestação inicial da síndrome da imunodeficiência adquirida--relato de caso.

The authors report a case of disseminated cutaneous infection with Sporothrix schenckii in a previously asymptomatic HIV-infected 30 year-old man. Extensive cutaneous involvement was observed with suppurative collections and ulcerations. The agent was isolated in culture. Treatment with liposomal amphotericin B proved to be effective.