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J Dtsch Dermatol Ges
; 20(12): 1657-1658, 2022 12.
Article
in English
| MEDLINE
| ID: mdl-36121369
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Bioorg Med Chem Lett
; 24(18): 4490-4495, 2014 Sep 15.
Article
in English
| MEDLINE
| ID: mdl-25127869
ABSTRACT
Since high MAO-B levels are present in early stages of AD, the MAO-B system can be designated as an appropriate and prospective tracer target of molecular imaging biomarkers for the detection of early AD. According to the preceding investigations of Mishra et al. the aim of this work was the development of a compound library of selective and reversible MAO-B inhibitors by performing bioisosteric modifications of the core structure of 3-(anthracen-9-yl)-5-phenyl-4,5-dihydro-1H-pyrazoles. In conclusion, 13 new pyrazoline based derivatives have been prepared, which will serve as precursor substances for future radiolabeling as well as reference compounds for the investigation of increased MAO-B levels in AD.