Is depression a risk factor for heart complaints? Longitudinal aspects in the Zurich study.

BACKGROUND: The objective of this longitudinal study was to assess the association between major depression and heart complaints in a population of young and healthy adults. METHODS: Starting at the age 20/21, participants of the Zurich Study underwent 6 structured, psychological interviews during a span of 20 years. We evaluated longitudinal data from 277 persons who participated in all 6 interviews including questions about heart complaints. RESULTS: Over 20 years, heart complaints were reported by two thirds of participants, and the frequency of depression was 11.4%. At the age of 40/ 41, heart complaints were significantly associated with earlier heart complaints and major depression, both more often in women. Recurrent brief depression showed a tendency, but neither minor depression nor depressive symptoms were predictive for later heart complaints. CONCLUSIONS: This study suggests that major depression is a predictor for heart complaints at the age of 40 and that the severity of depressive disorder in younger age has an effect on subsequent heart complaints. Follow-up data will help to elucidate whether these subjective heart complaints show any correlation with a later coronary heart disease.

WEXTOR: a Web-based tool for generating and visualizing experimental designs and procedures.

WEXTOR is a Javascript-based experiment generator and teaching tool on the World-Wide Web that can be used to design laboratory and Web experiments in guided step-by-step process. It dynamically creates the customized Web pages and Javascripts needed for the experimental procedure and provides experimenters with a print-ready visual display of their experimental design. WEXTOR flexibly supports complete and incomplete factorial designs with between-subjects, within-subjects, and quasi-experimental factors, as well as mixed designs. The software implements client-side response time measurement and contains a content wizard for creating interactive materials, as well as dependent measures (graphical scales, multiple-choice items, etc.), on the experiment pages. However, it does not aim to replace a full-fledged HTML editor. Several methodological features specifically needed in Web experimental design have been implemented in the Web-based tool and are described in this paper. WEXTOR is platform independent. The created Web pages can be uploaded to any type of Web server in which data may be recorded in logfiles or via a database. The current version of WEXTOR is freely available for educational and noncommercial purposes. Its Web address is http://www.genpsylab.unizh.ch/wextor/index.html.