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Bioorg Med Chem Lett
; 16(6): 1574-8, 2006 Mar 15.
Article
in English
| MEDLINE
| ID: mdl-16386905
ABSTRACT
High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.