A Predictive Visual Analytics System for Studying Neurodegenerative Disease Based on DTI Fiber Tracts.

Diffusion tensor imaging (DTI) has been used to study the effects of neurodegenerative diseases on neural pathways, which may lead to more reliable and early diagnosis of these diseases as well as a better understanding of how they affect the brain. We introduce a predictive visual analytics system for studying patient groups based on their labeled DTI fiber tract data and corresponding statistics. The system's machine-learning-augmented interface guides the user through an organized and holistic analysis space, including the statistical feature space, the physical space, and the space of patients over different groups. We use a custom machine learning pipeline to help narrow down this large analysis space and then explore it pragmatically through a range of linked visualizations. We conduct several case studies using DTI and T1-weighted images from the research database of Parkinson's Progression Markers Initiative.

Level Set Restricted Voronoi Tessellation for Large scale Spatial Statistical Analysis.

Spatial statistical analysis of multivariate volumetric data can be challenging due to scale, complexity, and occlusion. Advances in topological segmentation, feature extraction, and statistical summarization have helped overcome the challenges. This work introduces a new spatial statistical decomposition method based on level sets, connected components, and a novel variation of the restricted centroidal Voronoi tessellation that is better suited for spatial statistical decomposition and parallel efficiency. The resulting data structures organize features into a coherent nested hierarchy to support flexible and efficient out-of-core region-of-interest extraction. Next, we provide an efficient parallel implementation. Finally, an interactive visualization system based on this approach is designed and then applied to turbulent combustion data. The combined approach enables an interactive spatial statistical analysis workflow for large-scale data with a top-down approach through multiple-levels-of-detail that links phase space statistics with spatial features.

Scalable Visualization of Time-varying Multi-parameter Distributions Using Spatially Organized Histograms.

Visualizing distributions from data samples as well as spatial and temporal trends of multiple variables is fundamental to analyzing the output of today's scientific simulations. However, traditional visualization techniques are often subject to a trade-off between visual clutter and loss of detail, especially in a large-scale setting. In this work, we extend the use of spatially organized histograms into a sophisticated visualization system that can more effectively study trends between multiple variables throughout a spatial domain. Furthermore, we exploit the use of isosurfaces to visualize time-varying trends found within histogram distributions. This technique is adapted into both an on-the-fly scheme as well as an in situ scheme to maintain real-time interactivity at a variety of data scales.