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1.
Crit. Care Sci ; 35(4): 367-376, Oct.-Dec. 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1528492

ABSTRACT

ABSTRACT Objective: To assess the impact of different vertical positions on lung aeration in patients receiving invasive mechanical ventilation. Methods: An open-label randomized crossover clinical trial was conducted between January and July 2020. Adults receiving invasive mechanical ventilation for > 24 hours and < 7 days with hemodynamic, respiratory and neurological stability were randomly assigned at a 1:1 ratio to the sitting position followed by passive orthostasis condition or the passive orthostasis followed by the sitting position condition. The primary outcome was lung aeration assessed using the lung ultrasound score (score ranges from 0 [better] to 36 [worse]). Results: A total of 186 subjects were screened; of these subjects, 19 were enrolled (57.8% male; mean age, 73.2 years). All participants were assigned to receive at least one verticalization protocol. Passive orthostasis resulted in mean lung ultrasound scores that did not differ significantly from the sitting position (11.0 versus 13.7; mean difference, -2.7; [95%CI -6.1 to 0.71; p = 0.11). Adverse events occurred in three subjects in the passive orthostasis group and in one in the sitting position group (p = 0.99). Conclusion: This analysis did not find significant differences in lung aeration between the sitting and passive orthostasis groups. A randomized crossover clinical trial assessing the impact of vertical positioning on lung aeration in patients receiving invasive mechanical ventilation is feasible. Unfortunately, the study was interrupted due to the need to treat COVID-19 patients. ClinicalTrials.gov registry: NCT04176445


RESUMO Objetivo: Avaliar o impacto de diferentes posicionamentos verticais na aeração pulmonar em pacientes em ventilação mecânica invasiva. Métodos: Trata-se de ensaio clínico aberto, randomizado e transversal, realizado entre janeiro e julho de 2020. Adultos em ventilação mecânica invasiva por mais de 24 horas e menos de 7 dias com estabilidade hemodinâmica, respiratória e neurológica foram distribuídos aleatoriamente em uma proporção de 1:1 à postura sentada seguida da condição de ortostatismo passivo ou o ortostatismo passivo seguido de postura sentada. O desfecho primário foi a aeração pulmonar avaliada pelo lung ultrasound score. O escore varia de zero (melhor) a 36 (pior). Resultados: Foram selecionados 186 indivíduos; destes, 19 foram incluídos (57,8% do sexo masculino; média idade de 73,2 anos). Todos os participantes foram selecionados para receber pelo menos um protocolo de verticalização. O ortostatismo passivo resultou em escores médios de aeração pulmonar por ultrassonografia que não diferiram significativamente da postura sentada (11,0 versus 13,7; diferença média, -2,7; IC95% -6,1 a 0,71; p = 0,11). Ocorreram eventos adversos em três indivíduos no grupo ortostatismo passivo e em um no grupo postura sentada (p = 0,99). Conclusão: Esta análise não encontrou diferenças significativas na aeração pulmonar entre os grupos ortostatismo passivo e postura sentada. É factível conduzir um estudo clínico transversal randomizado para avaliar o impacto do posicionamento vertical na aeração pulmonar em pacientes em ventilação mecânica invasiva. Infelizmente, o estudo foi interrompido devido à necessidade de tratar pacientes com COVID-19. Registro ClinicalTrials.gov: NCT04176445

2.
Crit Care Sci ; 35(4): 367-376, 2023.
Article in English, Portuguese | MEDLINE | ID: mdl-38265318

ABSTRACT

OBJECTIVE: To assess the impact of different vertical positions on lung aeration in patients receiving invasive mechanical ventilation. METHODS: An open-label randomized crossover clinical trial was conducted between January and July 2020. Adults receiving invasive mechanical ventilation for > 24 hours and < 7 days with hemodynamic, respiratory and neurological stability were randomly assigned at a 1:1 ratio to the sitting position followed by passive orthostasis condition or the passive orthostasis followed by the sitting position condition. The primary outcome was lung aeration assessed using the lung ultrasound score (score ranges from 0 [better] to 36 [worse]). RESULTS: A total of 186 subjects were screened; of these subjects, 19 were enrolled (57.8% male; mean age, 73.2 years). All participants were assigned to receive at least one verticalization protocol. Passive orthostasis resulted in mean lung ultrasound scores that did not differ significantly from the sitting position (11.0 versus 13.7; mean difference, -2.7; [95%CI -6.1 to 0.71; p = 0.11). Adverse events occurred in three subjects in the passive orthostasis group and in one in the sitting position group (p = 0.99). CONCLUSION: This analysis did not find significant differences in lung aeration between the sitting and passive orthostasis groups. A randomized crossover clinical trial assessing the impact of vertical positioning on lung aeration in patients receiving invasive mechanical ventilation is feasible. Unfortunately, the study was interrupted due to the need to treat COVID-19 patients.ClinicalTrials.gov registry: NCT04176445.


Subject(s)
COVID-19 , Orthostatic Intolerance , Adult , Humans , Male , Aged , Female , Dizziness , Respiration, Artificial , Critical Care , Intensive Care Units
3.
J Chem Phys ; 157(21): 214303, 2022 Dec 07.
Article in English | MEDLINE | ID: mdl-36511526

ABSTRACT

In this work, the pressure- and temperature-dependent reaction rate constants for the hydrogen abstraction and addition of hydroxyl radicals to the unsaturated cyclopentene were studied. Geometries and vibrational frequencies of reactants, products, and transition states were calculated using density functional theory, with single-point energy corrections determined at the domain-based local pair natural orbital-coupled-cluster single double triple/cc-pVTZ-F12 level. The high-pressure limit rate constants were calculated using the canonical variational transition state theory with the small-curvature tunneling approximation. The vibrational partition functions were corrected by the effects of torsional and ring-puckering anharmonicities of the transition states and cyclopentene, respectively. Variational effects are shown to be relevant for all the hydrogen abstraction reactions. The increasing of the rate constants by tunneling is significant at temperatures below 500 K. The pressure dependence on the rate constants of the addition of OH• to cyclopentene was calculated using the system-specific quantum Rice-Ramsperger-Kassel model. The high-pressure limit rate constants decrease with increasing temperature in the range 250-1000 K. The falloff behavior was studied at several temperatures with pressures varying between 10-3 and 103 bar. At temperatures below 500 K, the effect of the pressure on the addition rate constant is very modest. However, at temperatures around and above 1000 K, taking pressure into account is mandatory for an accurate rate constant calculation. Branching ratio analyses reveal that the addition reaction dominates at temperatures below 500 K, decreasing rapidly at higher temperatures. Arrhenius parameters are provided for all reactions and pressure dependent Arrhenius parameters are given for the addition of OH• to cyclopentene.

4.
Pediatr Transplant ; 26(4): e14242, 2022 06.
Article in English | MEDLINE | ID: mdl-35122453

ABSTRACT

BACKGROUND: Perioperative pain management in small infants weighing <10 kg undergoing liver transplantation is challenging. The use of TEA in this setting has not been reported, as well as its potential role to facilitate IE, ie, in the OR. METHODS: We describe here the use of TEA in two small infants who had IE after a LDLT procedure. RESULTS: TEA was successfully performed and IE was achieved in both cases. Postoperative analgesia assessment in the OR was satisfactory according to the FLACC pain scale, with scores of 2 and 3 for each patient, respectively. There were no major complications in the postoperative period, and the two children were discharged home uneventfully. CONCLUSIONS: The use of TEA and its influence on IE rate and other perioperative outcomes should be more explored in small infants undergoing LDLT.


Subject(s)
Analgesia, Epidural , Liver Transplantation , Airway Extubation , Analgesia, Epidural/methods , Child , Humans , Infant , Liver Transplantation/methods , Living Donors , Pain Measurement
5.
Respir Physiol Neurobiol ; 266: 115-120, 2019 08.
Article in English | MEDLINE | ID: mdl-31096012

ABSTRACT

This study evaluated the ventilatory and haemodynamic effects of the mechanical insufflator-exsufflator (MI-E) in critically ill patients. Sixteen mechanically ventilated patients performed three protocols: MI-E (-30/+30 cmH2O) plus endotracheal suctioning; 50S: MI-E (-50/+50 cmH2O) plus endotracheal suctioning; and isolated endotracheal suctioning (IES). The protocols were applied randomly in all subjects, with 3 -h intervals in between. Peak airway pressure (Ppeak), plateau pressure (Pplat), airway resistance (Raw), static compliance (Cst), heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressure, peripheral oxygen saturation (SpO2) and amount of removed secretions were evaluated before (PRE), immediately after (POST) and 10 min after (10' POST) each protocol. The 50S protocol reduced Ppeak and Raw and increased Cst immediately after its application. Moreover, this protocol provided the largest amount of removed secretions and held SBP, DBP and SpO2 at basal values. The MI-E at high pressures promotes benefits to respiratory mechanics, is more effective in removing pulmonary secretions and it does not lead to hemodynamic repercussions.


Subject(s)
Critical Care , Hemodynamics , Insufflation/methods , Outcome and Process Assessment, Health Care , Respiration, Artificial , Respiratory Physiological Phenomena , Adult , Aged , Aged, 80 and over , Clinical Protocols , Cross-Over Studies , Female , Humans , Insufflation/instrumentation , Male , Middle Aged , Sputum
6.
Hepatobiliary Pancreat Dis Int ; 18(5): 423-429, 2019 Oct.
Article in English | MEDLINE | ID: mdl-30853253

ABSTRACT

BACKGROUND: Early allograft dysfunction (EAD) is a severe complication after liver transplantation. The associated risk factors and complications have re-gained recent interest. This study investigated risk factors, survival and complications associated with EAD in a large liver transplant center in Latin America. METHODS: Retrospective, unicenter, cohort, based on data from adult patients undergoing first deceased-donor liver transplant from January 2009 to December 2013. EAD was defined by one or more of the following: (i) bilirubin ≥10 mg/dL on postoperative day 7; (ii) international normalized ratio ≥1.6 on postoperative day 7, and (iii) alanine aminotransferase or aspartate aminotransferase >2000 IU/L within the first seven days after transplant. RESULTS: A total of 602 patients were included; of these 34.2% developed EAD. Donor risk factors were male (P = 0.007), age between 50 and 59 years (P = 0.034), overweight (P = 0.028) or grade I obesity (P = 0.012), sodium >157 mmol/L (P = 0.002) and grade IV ischemia/reperfusion injury (P = 0.002). Cold ischemia time ≥10 h (P = 0.008) and warm ischemia time ≥40 min (P = 0.013) were the surgical factors. Male (P <0.001) was the only recipient protective factor. Compared with the non-EAD group, patients with EAD were submitted to more reoperations (24.3% vs. 13.4%, P = 0.001) and had higher graft loss rates (37.9% vs. 21.2%, P <0.001), with similar patient survival rates (P = 0.238). CONCLUSIONS: EAD risk factors are related to donor, surgical procedure and recipient. Donor risk factors for EAD were male, age between 50 and 59 years, donor overweight or grade I obesity, sodium >157 mmol/L and grade IV ischemia/reperfusion injury. Cold ischemia time ≥10 h and warm ischemia time ≥40 min were the surgical risk factors. Male was the only recipient protective factor. Patients with EAD had higher reoperations and graft loss rates.


Subject(s)
Delayed Graft Function/etiology , Graft Survival , Liver Transplantation/adverse effects , Postoperative Complications/etiology , Adult , Age Factors , Allografts/physiopathology , Cold Ischemia/adverse effects , Female , Humans , Hypernatremia/complications , Male , Middle Aged , Obesity/complications , Protective Factors , Reperfusion Injury/complications , Retrospective Studies , Risk Factors , Sex Factors , Warm Ischemia/adverse effects , Young Adult
8.
Einstein (Säo Paulo) ; 14(4): 567-572, Oct.-Dec. 2016. tab
Article in English | LILACS | ID: biblio-840273

ABSTRACT

ABSTRACT Primary graft dysfunction is a multifactorial syndrome with great impact on liver transplantation outcomes. This review article was based on studies published between January 1980 and June 2015 and retrieved from PubMed database using the following search terms: “primary graft dysfunction”, “early allograft dysfunction”, “primary non-function” and “liver transplantation”. Graft dysfunction describes different grades of graft ischemia-reperfusion injury and can manifest as early allograft dysfunction or primary graft non-function, its most severe form. Donor-, surgery- and recipient-related factors have been associated with this syndrome. Primary graft dysfunction definition, diagnostic criteria and risk factors differ between studies.


RESUMO A disfunção primária do enxerto hepático é uma síndrome multifatorial com grande impacto no resultado do transplante de fígado. Foi realizada uma ampla revisão da literatura, consultando a base de dados PubMed, em busca de estudos publicados entre janeiro de 1980 e junho de 2015. Os termos descritivos utilizados foram: “primary graft dysfunction”, “early allograft dysfunction”, “primary non-function” e “liver transplantation”. A disfunção traduz graus diferentes da lesão de isquemia e reperfusão do órgão, e pode se manifestar como disfunção precoce ou, na forma mais grave, pelo não funcionamento primário do enxerto. Fatores relacionados ao doador, ao transplante e ao receptor contribuem para essa síndrome. Existem definições diferentes na literatura quanto ao diagnóstico e aos fatores de risco associados à disfunção primária.


Subject(s)
Humans , Tissue Donors , Liver Transplantation/adverse effects , Primary Graft Dysfunction , Aspartate Aminotransferases/blood , Syndrome , Risk Factors , Alanine Transaminase/blood , Primary Graft Dysfunction/diagnosis , Primary Graft Dysfunction/etiology , Primary Graft Dysfunction/physiopathology , Graft Survival
9.
Einstein (Sao Paulo) ; 14(4): 567-572, 2016.
Article in English, Portuguese | MEDLINE | ID: mdl-27783749

ABSTRACT

Primary graft dysfunction is a multifactorial syndrome with great impact on liver transplantation outcomes. This review article was based on studies published between January 1980 and June 2015 and retrieved from PubMed database using the following search terms: "primary graft dysfunction", "early allograft dysfunction", "primary non-function" and "liver transplantation". Graft dysfunction describes different grades of graft ischemia-reperfusion injury and can manifest as early allograft dysfunction or primary graft non-function, its most severe form. Donor-, surgery- and recipient-related factors have been associated with this syndrome. Primary graft dysfunction definition, diagnostic criteria and risk factors differ between studies. RESUMO A disfunção primária do enxerto hepático é uma síndrome multifatorial com grande impacto no resultado do transplante de fígado. Foi realizada uma ampla revisão da literatura, consultando a base de dados PubMed, em busca de estudos publicados entre janeiro de 1980 e junho de 2015. Os termos descritivos utilizados foram: "primary graft dysfunction", "early allograft dysfunction", "primary non-function" e "liver transplantation". A disfunção traduz graus diferentes da lesão de isquemia e reperfusão do órgão, e pode se manifestar como disfunção precoce ou, na forma mais grave, pelo não funcionamento primário do enxerto. Fatores relacionados ao doador, ao transplante e ao receptor contribuem para essa síndrome. Existem definições diferentes na literatura quanto ao diagnóstico e aos fatores de risco associados à disfunção primária.


Subject(s)
Liver Transplantation/adverse effects , Primary Graft Dysfunction , Tissue Donors , Alanine Transaminase/blood , Aspartate Aminotransferases/blood , Graft Survival , Humans , Primary Graft Dysfunction/diagnosis , Primary Graft Dysfunction/etiology , Primary Graft Dysfunction/physiopathology , Risk Factors , Syndrome
10.
Einstein (Sao Paulo) ; 13(1): 136-41, 2015.
Article in English, Portuguese | MEDLINE | ID: mdl-25993080

ABSTRACT

Intestinal transplantation has shown exceptional growth over the past 10 years. At the end of the 1990's, intestinal transplantation moved out of the experimental realm to become a routine practice in treating patients with severe complications related to total parenteral nutrition and intestinal failure. In the last years, several centers reported an increasing improvement in survival outcomes (about 80%), during the first 12 months after surgery, but long-term survival is still a challenge. Several advances led to clinical application of transplants. Immunosuppression involved in intestinal and multivisceral transplantation was the biggest gain for this procedure in the past decade due to tacrolimus, and new inducing drugs, mono- and polyclonal anti-lymphocyte antibodies. Despite the advancement of rigid immunosuppression protocols, rejection is still very frequent in the first 12 months, and can result in long-term graft loss. The future of intestinal transplantation and multivisceral transplantation appears promising. The major challenge is early recognition of acute rejection in order to prevent graft loss, opportunistic infections associated to complications, post-transplant lymphoproliferative disease and graft versus host disease; and consequently, improve results in the long run.


Subject(s)
Intestines/transplantation , Organ Transplantation/trends , Viscera/transplantation , Graft Survival , Humans , Liver Transplantation
11.
Einstein (Sao Paulo) ; 13(1): 149-52, 2015.
Article in English, Portuguese | MEDLINE | ID: mdl-25993082

ABSTRACT

In 1958 Francis Moore described the orthotopic liver transplantation technique in dogs. In 1963, Starzl et al. performed the first liver transplantation. In the first five liver transplantations no patient survived more than 23 days. In 1967, stimulated by Calne who used antilymphocytic serum, Starzl began a successful series of liver transplantation. Until 1977, 200 liver transplantations were performed in the world. In that period, technical problems were overcome. Roy Calne, in 1979, used the first time cyclosporine in two patients who had undergone liver transplantation. In 1989, Starzl et al. reported a series of 1,179 consecutives patients who underwent liver transplantation and reported a survival rate between one and five years of 73% and 64%, respectively. Finally, in 1990, Starzl et al. reported successful use of tacrolimus in patents undergoing liver transplantation and who had rejection despite receiving conventional immunosuppressive treatment. Liver Transplantation Program was initiated at Hospital Israelita Albert Einstein in 1990 and so far over 1,400 transplants have been done. In 2013, 102 deceased donors liver transplantations were performed. The main indications for transplantation were hepatocellular carcinoma (38%), hepatitis C virus (33.3%) and alcohol liver cirrhosis (19.6%). Of these, 36% of patients who underwent transplantation showed biological MELD score > 30. Patient and graft survival in the first year was, 82.4% and 74.8%, respectively. A major challenge in liver transplantation field is the insufficient number of donors compared with the growing demand of transplant candidates. Thus, we emphasize that appropriated donor/receptor selection, allocation and organ preservation topics should contribute to improve the number and outcomes in liver transplantation.


Subject(s)
Liver Transplantation , Animals , Brazil , Dogs , Graft Rejection , Graft Survival , History, 20th Century , History, 21st Century , Humans , Kaplan-Meier Estimate , Liver Transplantation/history , Liver Transplantation/statistics & numerical data , Liver Transplantation/trends , Treatment Outcome
12.
Einstein (Säo Paulo) ; 13(1): 149-152, Jan-Mar/2015. tab, graf
Article in English | LILACS | ID: lil-745888

ABSTRACT

In 1958 Francis Moore described the orthotopic liver transplantation technique in dogs. In 1963, Starzl et al. performed the first liver transplantation. In the first five liver transplantations no patient survived more than 23 days. In 1967, stimulated by Calne who used antilymphocytic serum, Starzl began a successful series of liver transplantation. Until 1977, 200 liver transplantations were performed in the world. In that period, technical problems were overcome. Roy Calne, in 1979, used the first time cyclosporine in two patients who had undergone liver transplantation. In 1989, Starzl et al. reported a series of 1,179 consecutives patients who underwent liver transplantation and reported a survival rate between one and five years of 73% and 64%, respectively. Finally, in 1990, Starzl et al. reported successful use of tacrolimus in patents undergoing liver transplantation and who had rejection despite receiving conventional immunosuppressive treatment. Liver Transplantation Program was initiated at Hospital Israelita Albert Einstein in 1990 and so far over 1,400 transplants have been done. In 2013, 102 deceased donors liver transplantations were performed. The main indications for transplantation were hepatocellular carcinoma (38%), hepatitis C virus (33.3%) and alcohol liver cirrhosis (19.6%). Of these, 36% of patients who underwent transplantation showed biological MELD score > 30. Patient and graft survival in the first year was, 82.4% and 74.8%, respectively. A major challenge in liver transplantation field is the insufficient number of donors compared with the growing demand of transplant candidates. Thus, we emphasize that appropriated donor/receptor selection, allocation and organ preservation topics should contribute to improve the number and outcomes in liver transplantation.


Em 1958, Francis Moore descreveu a técnica do transplante de fígado em cães. Em 1963, Starzl e sua equipe realizaram o primeiro transplante de fígado. Nos primeiros cinco transplante de fígado, nenhum paciente sobreviveu mais que 23 dias. Até 1977, aproximadamente 200 transplante de fígado tinham sido realizados no mundo. Neste período, foi estabelecida a solução de problemas técnicos do transplante de fígado. Calne, em 1979, utilizou, pela primeira vez, a ciclosporina em dois pacientes submetidos ao transplante de fígado. Starzl e seus colaboradores relataram, já em 1989, que a sobrevida de 1.179 pacientes submetidos ao transplante de fígado em 1 e 5 anos foi, respectivamente, de 73 e 64%. Finalmente, em 1990, Starzl relatou o primeiro uso do novo imunossupressor tacrolimo em pacientes de transplante de fígado que apresentavam rejeição mesmo com o tratamento imunossupressor convencional. O transplante de fígado iniciou-se no Hospital Israelita Albert Einstein em 1990 e já foram realizados mais de 1.400 transplantes. Em 2013, foram realizados 102 transplantes de fígado de doadores falecidos. As principais indicações para o transplante foram carcinoma hepatocelular (38%), cirrose hepática secundária ao vírus C (33,3%) e cirrose alcoólica (19,6%). Destes, 36% dos transplantes apresentavam MELD biológico superior a 30. As sobrevidas do paciente e do enxerto no primeiro ano foram, respectivamente, 82,4 e 74,8%. Um dos maiores desafios da área do transplante de fígado é o número insuficiente de doadores para uma demanda crescente de candidatos ao procedimento. Dessa forma, destacamos que tópicos relacionados à seleção de doadores/receptores, alocação e preservação de órgãos devem contribuir para o aumento e a melhora dos resultados do transplante de fígado.


Subject(s)
Animals , Dogs , History, 20th Century , History, 21st Century , Humans , Liver Transplantation , Brazil , Graft Rejection , Graft Survival , Kaplan-Meier Estimate , Liver Transplantation/history , Liver Transplantation/statistics & numerical data , Liver Transplantation/trends , Treatment Outcome
13.
Einstein (Säo Paulo) ; 13(1): 136-141, Jan-Mar/2015. tab
Article in English | LILACS | ID: lil-745889

ABSTRACT

Intestinal transplantation has shown exceptional growth over the past 10 years. At the end of the 1990’s, intestinal transplantation moved out of the experimental realm to become a routine practice in treating patients with severe complications related to total parenteral nutrition and intestinal failure. In the last years, several centers reported an increasing improvement in survival outcomes (about 80%), during the first 12 months after surgery, but long-term survival is still a challenge. Several advances led to clinical application of transplants. Immunosuppression involved in intestinal and multivisceral transplantation was the biggest gain for this procedure in the past decade due to tacrolimus, and new inducing drugs, mono- and polyclonal anti-lymphocyte antibodies. Despite the advancement of rigid immunosuppression protocols, rejection is still very frequent in the first 12 months, and can result in long-term graft loss. The future of intestinal transplantation and multivisceral transplantation appears promising. The major challenge is early recognition of acute rejection in order to prevent graft loss, opportunistic infections associated to complications, post-transplant lymphoproliferative disease and graft versus host disease; and consequently, improve results in the long run.


O transplante de intestino, ao redor do mundo, tem crescido de maneira sólida e consistente nos últimos 10 anos. No final da década de 1990, passou de um modelo experimental para uma prática clínica rotineira no tratamento dos pacientes com complicação severa da nutrição parenteral total com falência intestinal. Nos últimos anos, vários centros têm relatado uma crescente melhora nos resultados de sobrevida do transplante no primeiro ano (ao redor de 80%), porém, a longo prazo, ainda é desafiador. Diversos avanços permitiram sua aplicação clínica. O surgimento de novas drogas imunossupressoras, como o tacrolimus, além das drogas indutoras, os anticorpos antilinfocíticos mono e policlonal, nos últimos 10 anos, foi de suma importância para a melhora da sobrevida do transplante de intestino/multivisceral, mas, apesar dos protocolos bastante rígidos de imunossupressão, a rejeição é bastante frequente, podendo levar a altas taxas de perdas de enxerto a longo prazo. O futuro do transplante de intestino e multivisceral parece promissor. O grande desafio é reconhecer precocemente os casos de rejeição, prevenindo a perda do enxerto e melhorando os resultados a longo prazo, além das complicações causadas por infecções oportunistas, doenças linfoproliferativas pós-transplante e a doença do enxerto contra hospedeiro.


Subject(s)
Humans , Intestines/transplantation , Organ Transplantation/trends , Viscera/transplantation , Graft Survival , Liver Transplantation
14.
Saúde debate ; 38(102): 646-653, 09/2014. tab, graf
Article in Portuguese | LILACS-Express | LILACS | ID: lil-726397

ABSTRACT

A prática regular de caminhada pode tornar a população mais ativa fisicamente. Buscamos relatar as atividades desenvolvidas com praticantes de caminhada em ambientes públicos de lazer em Uruguaiana - RS. Os participantes foram entrevistados, avaliados fisicamente, e divididos em faixas etárias. Resultados sugerem que idosos têm maior frequência e são motivados pela orientação médica. Jovens assumem prazer na realização da prática. Adultos de meia idade são maioria, e se exercitam pela preocupação com a saúde. Alterações posturais observadas sugerem precaução quanto ao tipo e forma de atividade física praticada, mostrando a necessidade de maior orientação profissional em espaços de lazer.


Walking can help people become physically active. We present a report concerning activities developed with walkers in a public space for leisure in Uruguaiana - RS. Participants were interviewed, underwent a simple physical examination and divided into age groups. Elderly are more frequent in weekly activities, motivated by medical personnel. Young people indicated enjoyment when performing walking or running. Middle-aged adults are the majority, and exercise for health concerns. The concerns of users and postural alterations suggest concern regarding the modality and development of the physical activity, denoting that the professional orientation in these leisure spaces should be considered.

15.
Rev. bras. ciênc. mov ; 22(2): 36-46, jan.-mar.2014. tab
Article in Portuguese | LILACS | ID: lil-733938

ABSTRACT

Atualmente, dados reportam um alto índice de reprovação em escolares nos anos iniciais do ensino fundamental, de escolas publicas do país. Neste contexto, o aprendizado e o rendimento escolar são influenciados por diversos fatores, sendo que controlá-los representa um desafio cada vez mais presente na realidade sócio-educacional. Ainda, algumas escolas públicas carecem de professores de educação física neste nível de ensino, e estudos demonstram uma relação direta entre atrasos no desenvolvimento motor, devido à falta de atividade física, e dificuldades de aprendizagem em escolares. Sabendo dos vários fatores que podem estar associados com o mau desempenho escolar destas crianças, o objetivo deste trabalho foi identificar o perfil físico, bem como os níveis de ansiedade, motivação e atenção, de estudantes nos anos iniciais com baixo rendimento escolar, e, a partir destes dados, discutir a importância da inserção do professor de educação física. Assim, trata-se de um estudo quantitativo, de caráter transversal, onde foram incluídos 22 estudantes do sexo masculino, compreendendo uma faixa-etária de 10 à 12 anos de idade, com baixo rendimento escolar, selecionados por professores de escolas públicas, do município de Uruguaiana/RS. Os resultados demonstraram que estes alunos apresentaram um risco para sobrepeso corporal, um alto nível de insatisfação com a imagem corporal, uma baixa motivação e um grande déficit nos níveis de atenção. Frente a estes achados, a atuação do professor de educação física se faz pertinente nos anos iniciais do ensino fundamental, uma vez que o estímulo à prática de atividade física influencia positivamente o perfil físico das crianças, melhorando a percepção da imagem corporal, além de atuar sobre aspectos de motivação, ansiedade e atenção, podendo favorecer o desempenho escolar.


Currently data report a high failure index in students in the early years of the public schools in the country. In this sense, the learning and school performance are influenced by many factors, and controlling the same is a current challenge in the socio-educational reality. So, some public schools require physical education teachers at this level of education, and studies show a direct relationship between delays in motor development due to lack of physical activity, and learning difficulties in students. Knowing the several factors that can be associated with low school performance these children, the purpose this study was to identify the physical profile, as well as the anxiety, motivation and attention levels of students in the early years with low school performance, and from these data, discuss the importance of the physical education teacher inset. So, it’s a quantitative study of crosscutting nature, which were included 22 male students, comprising an age range 10-12 years with low school performance, selected by teachers in the city of Uruguaiana/RS – Brazil. The results showed which these students had a risk for overweight body, a high level of dissatisfaction with body image, low motivation and a large deficit in attention levels. View these findings, the acting of physical education teacher becomes relevant in the early years of elementary school, once the stimulus to the practice of physical activity induce the children’s physical profile, improving the body image perception and acts on motivation, anxiety and attention aspects and can improve school performance.


Subject(s)
Humans , Male , Child , Physical Education and Training , Students , Underachievement , Child , Men
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