ABSTRACT
Pulmonary complications are important cause of mortality and morbidity after hematopoietic stem cell transplantation, in 30% to 60% of the patients. Improvements in prophylaxis and treatment of infectious complications have been increasing the rate of non-infectious complications. Early diagnosis and treatment of those complications can significantly change the evolution of hematopoietic stem cell transplantation receptors. The objective of this study is to review the most frequent non-infection complications associated to hematopoietic stem cell transplantation since the first bone marrow transplantation performed in 1957. A systematic literature review was performed, using the PICO strategy to ask the questions. The descriptors hematopoietic stem cell transplantation, non-infectious pulmonary complications, systematic review, in portuguese and their english correspondents, were used to access the following databases: MEDLINE, EBM, Embase, Cocrane Library, LILACS and SciELO. In this review, 263 studies were identified, from which 31 were selected for full analyzis. The non-infection pulmonary complications most frequently found were: bronchiolitis obliterans, bronchiolitis obliterans organizing pneumonia, pulmonary edema, idiopathic pneumonia syndrome, delayed pulmonary toxicity syndrome, diffuse alveolar hemorrhage, engrafment syndrome and pulmonary cytolitic thrombi.
Subject(s)
Hematopoietic Stem Cell Transplantation/adverse effects , Lung Diseases/etiology , Algorithms , Bronchiolitis Obliterans/etiology , Humans , Lung Diseases/diagnosis , Lung Diseases/therapyABSTRACT
Este relato descreve a evolução clínica de paciente de 27 anos de idade, admitida no Hospital das Clínicas da UFMG com diagnóstico de corioamnionite, em quem foi necessária a indução do parto. Evoluiu com choque séptico, sendo necessários o suporte avançado de vida em terapia intensiva e a administração de antibioticoterapia de amplo espectro. Recebeu alta no décimo terceiro dia de internação hospitalar. Seu recém-nascido teve inúmeras complicações e evoluiu para o óbito. A corioamnionite manifesta-se com síndrome febril, taquicardia materna e fetal, leucocitose com desvio para a esquerda, dor pélvica e corrimento vaginal. Requer antibioticoterapia e realização do parto. Associa-se ao desenvolvimento de várias complicações, como hemorragia pós-parto, abscesso pélvico, sepse neonatal, leucomalácia periventricular cística e paralisia cerebral. A melhor assistência pré-natal e a adequada formação dos obstetras podem prevenir a ocorrência de corioamnionite, assim como suas complicações.
Chorioamnionitis is an infection of the amniotic fluid, fetal membranes, placenta, and/or decidua, involving 0.5% to 10% of all pregnancies. With the onset of labor or with ruptures of membranes, bacteria from the lower genital tract are able to ascend into the amniotic cavity, causing infection. This article reports the case of a 27-year-old pregnant woman, admitted to the Hospital das Clinicas of UFMG, with the diagnosis of chorioamnionitis, having been submitted to labor induction. The patient progressed to septic shock, being hospitalized in the ICU and receiving broad-spectrum antibiotic and support therapy, being discharged at the 13th day of hospitalization. The newborn had numerous complications and died. Chorioamnionitis - manifested by fever, maternal and fetal tachycardia, leukocytosis, uterine tenderness and vaginal discharge - requires antibiotic therapy and delivery. Its linked to complications such as postpartum hemorrhage, pelvic abscess, and neonatal sepsis, cystic periventricular leukomalacia and cerebral palsy. A better prenatal care and proper training of obstetricians can prevent the occurrence of chorioamnionitis, as well as its complications.
