A Modern-Day Fight Club? The Stabilization and Management of Acutely Agitated Patients in the Emergency Department.

This article is an overview of the treatment and management of acutely agitated patients as they present in the emergency department or emergency psychiatric facility. This article focuses on how a patient encounter may unfold and what issues need to be considered along the way. Verbal de-escalation is emphasized as a standard of care, including the offering of environmental changes and medications when indicated. Approved medications are reviewed as well as the proper use of restraints.

Do the cup surface properties influence the initial stability?

This project tests the relationship between the acetabular cup surface characteristics and their initial stability by comparing uncemented (Trabecular Metal (TM) and Trilogy) and cemented polyethylene shells. We hypothesised that different surface properties of uncemented cups will influence the cup stability. Mounted directly onto host bone, TM and cemented cups were significantly more stable than Trilogy cups (P < 0.01), with minimal difference between TM and cemented cups (P > 0.1). On 100% graft bed, there was marginal difference between all three cup types (P > 0.1). Incremental cavitary and segmental defects resulted in reducing stability, with cemented cups being minimally more stable (P > 0.1). TM cups possess satisfactory initial stability in bone graft constructs. This study demonstrates that TM shells are marginally less stable than cemented cups in the absence of significant host bone contact.

Influence of the change in stem length on the load transfer and bone remodelling for a cemented resurfaced femur.

The effect of a short-stem femoral resurfacing component on load transfer and potential failure mechanisms has rarely been studied. The stem length has been reduced by approximately 50% as compared to the current long-stem design. Using 3-D FE models of natural and resurfaced femurs, the study is aimed at investigating the influence of a short-stem resurfacing component on load transfer and bone remodelling. Applied loading conditions include normal walking and stair climbing. The mechanical role of the stem along with implant-cement and stem-bone contact conditions was observed to be crucial. Shortening the stem length to half of the current length (long-stem) led to several favourable effects, even though the stress distributions in the implant and the cement were similar in both the cases. The short-stem implant led not only to a more physiological stress distribution but also to bone apposition (increase of 20-70% bone density) in the superior resurfaced head, when the stem-bone contact prevailed. This also led to a reduction in strain concentration in the cancellous bone around the femoral neck-component junction. The normalised peak strain in this region was lower for the short-stem design as compared to that of the long-stem one, thereby reducing the initial risk of neck fracture. The effect of strain shielding (50-75% reduction) was restricted to a small bone volume underlying the cement, which was approximately half of that of the long-stem design. Consequently, bone resorption was considerably less for the short-stem design. The short-stem design offers better prospects than the long-stem resurfacing component.

Strain and micromotion in intact and resurfaced composite femurs: experimental and numerical investigations.

Understanding the load transfer within a resurfaced femur is necessary to determine the influence of mechanical factors on potential failure mechanisms such as early femoral neck fractures and stress shielding. In this study, an attempt has been made to measure the stem-bone micromotion and implant cup-bone relative displacements (along medial-lateral and anterior-posterior direction), in addition to surface strains at different locations and orientations on the proximal femur and to compare these measurements with those predicted by equivalent FE models. The loading and the support conditions of the experiment were closely replicated in the FE models. A new experimental set-up has been developed, with specially designed fixtures and load application mechanism, which can effectively impose bending and deflection of the tested femurs, almost in any direction. High correlation coefficient (0.92-0.95), low standard error of the estimate (170-379 muepsilon) and low percentage error in regression slope (12.8-17.5%), suggested good agreement between the numerical and measured strains. The effect of strain shielding was observed in two (out of eight) strain gauges located on the posterior side. A pronounced strain increase occurred in strain gauges located on the anterior head and neck regions after implantation. Experimentally measured stem-bone micromotion and implant cup-bone relative displacements (0-13.7 microm) were small and similar in trends predicted by the FE models (0-25 microm). Despite quantitative deviations in the measured and numerical results, it appears that the FE model can be used as a valid predictor of the actual strain and stem-bone micromotion.

The effects of interfacial conditions and stem length on potential failure mechanisms in the uncemented resurfaced femur.

It is hypothesized that changes in stem length and implant-bone interfacial conditions would affect the mechanical environment within the uncemented resurfaced femur, thereby influencing potential short- and long-term failure mechanisms. This study is aimed at investigating the influence of changes in implant-bone interfacial conditions and stem length on eventual failure, using 3D FE models integrated with bone remodeling simulations. Musculoskeletal forces corresponding to normal walking and stair climbing were used as applied loading conditions. Sliding micromotions of 26-72 microm at the implant-bone interfaces for both the stem designs suggest bone ingrowth on the coated surface of the implant was likely. The initial risk of femoral neck fracture was less for the uncemented designs as compared to the cemented designs, irrespective of interfacial conditions and variation in stem length. For the uncemented variety, shortening the stem length provided only slight advantages (5%) with regard to strain shielding and bone remodeling. However, bone resorption was considerably higher when fully bonded interfaces were simulated. It may, therefore, be concluded that cementless fixation seems to be a viable alternative to cemented fixation, provided sufficient initial fixation and secondary stability through bone ingrowth into the coated surface of the implant can be achieved.

Probabilistic finite element analysis of the uncemented hip replacement--effect of femur characteristics and implant design geometry.

In the present study, a probabilistic finite element tool was assessed using an uncemented total hip replacement model. Fully bonded and frictional interfaces were investigated for combinations of three proximal femurs and two implant designs, the Proxima short stem and the IPS hip stem prostheses. The Monte Carlo method was used with two performance indicators: the percentage of bone volume that exceeded specified strain limits and the maximum nodal micromotion. The six degrees of freedom of bone-implant relative position, magnitude of the hip contact force (L), and spatial direction of L were the random variables. The distal portion of the proximal femurs was completely constrained and some of the main muscle forces acting in the hip were applied. The coefficients of the linear approximation between the random variables and the output were used as the sensitivity values. In all cases, bone-implant position related parameters were the most sensitive parameters. The results varied depending on the femur, the implant design and the interface conditions. Values of maximum nodal micromotion agreed with results from previous studies, confirming the robustness of the implemented computational tool. It was demonstrated that results from a single model study should not be generalised to the entire population of femurs and that bone variability is an important factor that should be investigated in such analyses.

Finite element analysis of unicompartmental knee arthroplasty.

Concerns over accelerated damage to the untreated compartment of the knee following unicompartmental knee arthroplasty (UKA), as well as the relatively poor success rates observed for lateral as opposed to the medial arthroplasty, remain issues for attention. Finite element analysis (FEA) was used to assess changes to the kinematics and potential for cartilage damage across the knee joint in response to the implantation of the Oxford Mobile Bearing UKA. FE models of lateral and medial compartment arthroplasty were developed, in addition to a healthy natural knee model, to gauge changes incurred through the arthroplasty. Varus-valgus misalignments were introduced to the femoral components to simulate surgical inaccuracy or over-correction. Boundary conditions from the Stanmore knee simulator during the stance phase of level gait were used. AP translations of the tibia in the medial UKA models were comparable to the behaviour of the natural knee models (+/-0.6mm deviation from pre-operative motion). Following lateral UKA, 4.1mm additional posterior translation of the tibia was recorded than predicted for the natural knee. IE rotations of the medial UKA models were less consistent with the pre-operative knee model than the lateral UKA models (7.7 degrees vs. 3.6 degrees deviation). Varus misalignment of the femoral prosthesis was more influential than valgus for medial UKA kinematics, whereas in lateral UKA, a valgus misalignment of the femoral prosthesis was most influential on the kinematics. Resection of the cartilage in the medial compartment reduced the overall risk of progressive OA in the knee, whereas removing the cartilage from the lateral compartment, and in particular introducing a valgus femoral misalignment, increased the overall risk of progressive OA in the knee. Based on these results, under the conditions tested herein, both medial and lateral UKA can be said to induce kinematics of the knee which could be considered broadly comparable to those of the natural knee, and that even a 10 degrees varus-valgus misalignment of the femoral component may not induce highly irregular kinematics. However, elevated posterior translation of the tibia in lateral UKA and large excursions of the insert may explain the higher incidence of bearing dislocation observed in some clinical studies.

A computational tool for the probabilistic finite element analysis of an uncemented total hip replacement considering variability in bone-implant version angle.

In the present study, a probabilistic finite element tool was implemented to assess an uncemented total hip replacement including variability in bone-implant version angle. The Monte Carlo method was used with two different performance indicators: the bone maximum nodal von-Mises elastic strain and the bone volume (BV) percentage exceeding specified strain limits. Implant version, bone stiffness and load magnitude were the most sensitive parameters. The results were more consistent using percentage BV under specified limit strains as the performance indicator, even for a low number of simulations. The reliability of the computational tool was demonstrated through a comparison with previous studies, and the consistency of the results for all strain limits investigated.

Design considerations for ceramic resurfaced femoral head: effect of interface characteristics on failure mechanisms.

Ceramic hip resurfacing may offer improved wear resistance compared to metallic components. The study is aimed at investigating the effects of stiffer ceramic components on the stress/strain-related failure mechanisms in the resurfaced femur, using three-dimensional finite element models of intact and resurfaced femurs with varying stem­bone interface conditions. Tensile stresses in the cement varied between 1 and 5 MPa. Postoperatively, 20­85% strain shielding was observed inside the resurfaced head. The variability in stem­bone interface condition strongly influenced the stresses and strains generated within the resurfaced femoral head. For full stem­bone contact, high tensile (151­158 MPa) stresses were generated at the cup­stem junction, indicating risk of fracture. Moreover, there was risk of femoral neck fracture due to elevated bone strains (0.60­0.80% strain) in the proximal femoral neck region. Stresses in the ceramic component are reduced if a frictionless gap condition exists at the stem­bone interface. High stresses, coupled with increased strain shielding in the ceramic resurfaced femur, appear to be major concerns regarding its use as an alternative material.

Probabilistic analysis of an uncemented total hip replacement.

This paper describes the application of probabilistic design methods to the analysis of the behaviour of an uncemented total hip replacement femoral component implanted in a proximal femur. Probabilistic methods allow variations in factors which control the behaviour of the implanted femur (the input parameters) to be taken into account in determining the performance of the construct. Monte Carlo sampling techniques were applied and the performance indicator was the maximum strain in the bone. The random input parameters were the joint load, the angle of the applied load and the material properties of the bone and the implant. Two Monte Carlo based simulations were applied, direct sampling and latin hypercube sampling. The results showed that the convergence of the mean value of the maximum strain improved gradually as a function of the number of simulations and it stabilised around a value of 0.008 after 6200 simulations. A similar trend was observed for the cumulative distribution function of the output. The strain output was most sensitive to the bone stiffness, followed very closely by the magnitude of the applied load. The application of latin hypercube sampling with 1000 simulations gave similar results to direct sampling with 10,000 simulations in a much reduced time. The results suggested that the number of simulations and the selection of parameters and models are important for the reliability of both the probability values and the sensitivity analyses.

The role of vibration and drainage in femoral impaction bone grafting.

Vibration is commonly used in civil engineering applications to efficiently compact aggregates. This study examined the effect of vibration and drainage on bone graft compaction and cement penetration in an in vitro femoral impaction bone grafting model with the use of 3-dimensional micro-computed tomographic imaging. Three regions were analyzed. In the middle and proximal femoral regions, there was a significant increase in the proportion of bone grafts with a reciprocal reduction in water and air in the vibration-assisted group (P < .01) as compared with the control group, suggesting tighter graft compaction. Cement volume was also significantly reduced in the middle region in the vibration-assisted group. No difference was observed in the distal region. This study demonstrates the value of vibration and drainage in bone graft compaction, with implications therein for clinical application and outcome.

Adult mesenchymal stem cells and impaction grafting: a new clinical paradigm shift.

The demographic challenges of an increasingly aging population emphasize the need for innovative approaches to skeletal reconstruction to augment and repair skeletal tissue lost as a consequence of implant loosening, trauma, degeneration or in situations involving revision surgery requiring bone stock. These clinical imperatives to augment skeletal tissue loss have brought mesenchymal stem cells to the fore in combination with the emerging discipline of tissue engineering. To date, impaction bone grafting for revision hip surgery is a recognized technique to reconstitute bone utilizing morselized allograft to provide a good mechanical scaffold, although with little osteoinductive biological potential. This review details laboratory and clinical examples of a paradigm shift in the application of mesenchymal stem cells with allograft to produce a living composite using the principles of tissue engineering. This step change creates a composite that offers a biological and mechanical advantage over the current gold standard of allograft alone. This translation of tissue engineering concepts into clinical practice offers enormous input into the field of bone regeneration and has implications for translation and future change in skeletal orthopedic practice in an increasingly aging population.

Making strong cords from surgical sutures.

The authors present a simple and cost effective technique of preparing strong cords from surgical sutures. The technique requires suture material, a drill, a clip and it takes less than a minute to prepare. The mechanical strength of the cord obtained by this method was compared to the mechanical strength of a single suture. Cords containing eight thicknesses of the suture material failed at slightly under eight times the single suture strength. A loop made out of cords of number 2 Vicryl or Dexon failed at loads of more than 1000 N. The authors have found these cords extremely useful and effective for reconstruction of the dislocated acromio-clavicular joint and also for the fixation of trans-femoral osteotomies.

Bone remodelling inside a cemented resurfaced femoral head.

BACKGROUND: Although the short-term performance of modern resurfacing hip arthroplasty is impressive, the long-term performance is still unknown. It is hypothesised that bone remodelling and the resulting changes in stress/strain distribution within the resurfaced femur influence the risk of fixation failure. METHOD: Three-dimensional finite element models and adaptive bone remodelling algorithms have been used to predict long-term changes in bone density following cemented femoral head resurfacing. Applied loading conditions include normal walking and stair climbing. The remodelling simulation was validated by comparing the results of an analysis of a proximal femur implanted with a Charnley femoral component with known clinical data in terms of bone density adaptations. FINDINGS: Resurfacing caused a reduction of strain of 20-70% in the bone underlying the implant as compared to the intact femur, immediately post operative. Elevated strains, ranging between 0.50 and 0.80% strain, were generated post-operatively around the proximal femoral neck regions, indicating a potential risk of neck fracture. However, this strain concentration was considerably reduced after bone remodelling. After remodelling, bone resorption of 60-90% was observed in the bone underlying the implant. Reduction in bone density of 5-47% occurred in the lateral femoral head. Bone apposition was observed in the proximal-medial cortex, around the inferior edge of the implant. Hardly any changes in bone density occurred in the distal neck or the femoral diaphysis. INTERPRETATION: Although resurfacing has produced encouraging clinical results, bone remodelling within the femoral head might be a concern for long-term fixation. Regions of strain concentration at the head-neck junction, which may increase the initial risk of femoral neck fracture, are reduced with bone remodelling. In order to reduce this risk of femoral neck fracture, patients should avoid activities which induce high loading of the hip during the early rehabilitation period after surgery.

Taking tissue-engineering principles into theater: augmentation of impacted allograft with human bone marrow stromal cells.

Human bone marrow contains bone progenitor cells that arise from multipotent mesenchymal stem cells. Seeding bone progenitor cells onto a scaffold can produce a 3D living composite with significant mechanical and biological potential. This article details laboratory and clinical findings from two clinical cases, where different proximal femoral conditions were treated using impacted allograft augmented with marrow-derived autogenous progenitor cells. Autologous bone marrow was seeded onto highly washed morselized allograft and impacted. Samples of the impacted graft were also taken for ex vivo analysis. Both patients made an uncomplicated clinical recovery. Imaging confirmed defect filling with encouraging initial graft incorporation. Histochemical and alkaline phosphatase staining demonstrated that a live composite graft with osteogenic activity had been introduced into the defects. These studies demonstrate that marrow-derived cells can adhere to highly washed morselized allograft, survive the impaction process and proliferate with an osteoblastic phenotype, thus creating a living composite.

Biological and mechanical enhancement of impacted allograft seeded with human bone marrow stromal cells: potential clinical role in impaction bone grafting.

With the demographics of an aging population the incidence of revision surgery is rapidly increasing. Clinical imperatives to augment skeletal tissue loss have brought mesenchymal stem cells to the fore in combination with the emerging discipline of tissue engineering. Impaction bone grafting for revision hip surgery is a recognized technique to reconstitute bone, the success of which relies on a combination of mechanical and biological factors. The use of morsellized allograft is currently the accepted clinical standard providing a good mechanical scaffold with little osteoinductive biological potential. We propose that applying the principles of a tissue engineering paradigm, the combination of human bone marrow stromal cells (hBMSCs) with allograft to produce a living composite, offers a biological and mechanical advantage over the current gold standard of allograft alone. This study demonstrates that hBMSCs combined with allograft can withstand the forces equivalent to a standard femoral impaction and continue to differentiate and proliferate along the bony lineage. In addition, the living composite provides a biomechanical advantage, with increased interparticulate cohesion and shear strength when compared with allograft alone.

Acetabular cementing technique in THA--flanged versus unflanged cups, cadaver experiments.

BACKGROUND: There are few studies on the effect of acetabular cup design on cement penetration. MATERIAL AND METHODS: We evaluated the effects of an acetabular flange on cement pressurization and cement penetration in 12 cadavers. Flanged or unflanged cups were implanted in paired human acetabula with simulated intraosseous bleeding pressure but without cement pressurization before insertion of the cup. Three pressure transducers were used to record intra-acetabular peak and average pressures during cup insertion. Following implantation, the whole specimens were AP-radiographed and standardized sections through the acetabula were microradiographed to evaluate cement penetration. RESULTS: Flanged cups produced greater intra-acetabular peak pressures than unflanged cups, but did not increase the average intra-acetabular pressure. Cement penetration did not differ significantly between the two groups. INTERPRETATION: Our findings do not support the use of flanged cups as the sole means of cement pressurization in the acetabulum.

A new bleeding model of the human acetabulum and a pilot comparison of 2 different cement pressurizers.

In this cadaver study, we compared 2 different acetabular cement pressurizers (Exeter and Bernoski type) in paired human acetabula with simulated intraosseous bleeding. Pressure transducers were used to record intra-acetabular pressures during pressurization. Anteroposterior radiographs of the entire specimens were taken. Subsequently, standardized 3-mm-thick sections were cut through the acetabula, which were then microradiographed to evaluate cement penetration. Adequate pressurization was obtained with either pressurizer. The peak and sustained pressures obtained with the Exeter pressurizer (peak, 80 kPa; sustained, 38 kPa) tended to be higher than the pressures obtained with the Bernoski pressurizer (73 kPa; 24 kPa; P > 0.05). Accordingly, a tendency toward improved cement penetration into cancellous bone was found using the Exeter pressurizer (P >.05).