ABSTRACT
ParaSHIFT agents have shown promise in detecting chemical targets in biological systems by magnetic resonance, but few studies have used transition metal complexes for this purpose. Here we report our investigations into CoMe6trenCl (tren = tris(2-aminoethyl)amine) as a paraSHIFT agent. The paramagnetic region of the 1H NMR spectrum shows characteristic spectral profiles in the presence of fluoride, acetate, lactate and citrate in aqueous solution. These distinctive NMR shifts of each anion are maintained even in mixtures of anions.
ABSTRACT
Health and Local Education Authority (LEA) personnel met in 1993 to consider how to meet the expanding caseload of children, needing speech and language therapy support in mainstream schools. The drive towards an inclusive policy for all children with special needs led to the joint funding of a peripatetic team of speech and language therapists (SLTs) and assistants. The preparatory training programmes for the team and school based staff focused on ensuring that differing perceptions, expectations and skills were acknowledged. Evaluation of the model has examined throughput, the opinion of consumers, pre- and post-therapy profiles of individual children and the team's view of their effectiveness in each school. The rotational service was implemented in 20 schools in January 1996 and 50 schools now participate.
Subject(s)
Education, Special/methods , Language Therapy/methods , Models, Educational , Speech Therapy/methods , Child , Education, Special/organization & administration , Forecasting , Humans , Mainstreaming, Education , Program DevelopmentSubject(s)
Appendix/pathology , Colonic Diseases/etiology , Intestinal Pseudo-Obstruction/etiology , Aged , Aged, 80 and over , Female , Gangrene , HumansABSTRACT
DSM-III and DSM-III-R diagnoses of 112 developmentally disordered preschool children were compared. There was no significant difference between the DSM-III and DSM-III-R diagnosis of the inclusive category of pervasive developmental disorder, but nearly twice as many cases (58) were diagnosed as autistic disorder by DSM-III-R criteria as were diagnosed as infantile autism (31) by DSM-III. Thirty children met both DSM-III and DSM-III-R criteria for autism (IA/AD) and 23 received a DSM-III diagnosis of atypical PDD (A-PDD) and a DSM-III-R diagnosis of AD (A-PDD/AD). All of the IA/AD children and none of the A-PDD/AD group displayed a marked lack of awareness of others. DSM-III-R criteria have specifically broadened the concept of autism to include children who, although socially impaired, are not pervasively unresponsive to others.
