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1.
J Antibiot (Tokyo) ; 37(8): 885-91, 1984 Aug.
Article in English | MEDLINE | ID: mdl-6480505

ABSTRACT

The synthesis of a series of analogues of clavulanic acid, possessing a substituted 1,2,3-triazole ring in place of the exocyclic hydroxyl group, is described. Quantitative structure-activity relationships in this series are discussed.


Subject(s)
Clavulanic Acids/pharmacology , Magnetic Resonance Spectroscopy , Microbial Sensitivity Tests , Structure-Activity Relationship
3.
Steroids ; 26(2): 219-25, 1975 Aug.
Article in English | MEDLINE | ID: mdl-1189005

ABSTRACT

3alpha-Hydroxy-5alpha-pregnane-11,20-dione-[21-14C] and 3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione-[21-14C] 21-acetate were prepared from a common radio-labelled intermediate, 21-diazo-3alpha-hydroxy-5alpha-pregnane-11,20-dione-[21-14C] 3-nitrate, obtained by the reaction of 17beta-chlorocarbonyl-3alpha-hydroxy-5alpha-androstan-11-one 3-nitrate with diazomethane-[14C].


Subject(s)
Alfaxalone Alfadolone Mixture/chemical synthesis , Pregnanediones/chemical synthesis , Carbon Radioisotopes , Chromatography, Gas , Chromatography, Thin Layer , Isotope Labeling , Methods
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