ABSTRACT
PURPOSE: To assess differences in surface energy due to processing induced disorder and to understand whether the disorder dominated the surfaces of particles. METHODS: Inverse gas chromatography was used to compare the surface energies of crystalline, amorphous, and ball milled lactose. RESULTS: The milling process made ca 1% of the lactose amorphous, however the dispersive contribution to surface energy was 31.2, 37.1, and 41.6 mJ m(-2) for crystalline, spray dried and milled lactose, respectively. A physical mixture of crystalline (99%) and amorphous (1%) material had a dispersive surface energy of 31.5 mJ m(-2). CONCLUSION: Milling had made the surface energy similar to that of the amorphous material in a manner that was very different to a physical mixture of the same amorphous content. The milled material will have similar interfacial interactions to the 100% amorphous material.
Subject(s)
Excipients/chemistry , Lactose/chemistry , Algorithms , Chemical Phenomena , Chemistry, Physical , Chromatography, Gas , Crystallization , Drug Compounding , Surface PropertiesABSTRACT
The purpose of this study was to assess the effect of relative humidity (RH) on the surface energy of amorphous lactose. Two samples of amorphous lactose were investigated; a spray dried 100% amorphous material and a ball milled sample of crystalline lactose. The milled sample had less than 1% amorphous content by mass, but on investigation at 0% RH, yielded surface energies comparable to those obtained from the 100% amorphous material, indicating that the surface was amorphous. The effect of increasing humidity was to reduce the dispersive surface energy of the two samples from 36.0 +/- 0.14 and 41.6 +/- 1.4 mJ m(-2) at 0% RH for the spray dried and milled samples respectively, to a value comparable to that obtained for the crystalline alpha-lactose monohydrate of 31.3 +/- 0.41 mJ m(-2). The change in surface energy due to water sorption was only reversible up to 20% RH; after exposure to higher RH values subsequent drying did not result in a return to the original surface energy of the amorphous form. This shows that the surface is reorganising as the glass transition temperature (Tg) is reduced, even though the sample has not collapsed or crystallised. It was possible to follow the collapse behaviour in the column with ease, using a number of different methods.
Subject(s)
Chromatography, Gas , Humidity , Lactose/chemistry , Absorption , Chromatography, Gas/instrumentation , CrystallizationABSTRACT
Science and technology are themselves a part of our modern culture. They contribute to the arts, furnish new media for human expression, provide better and new musical instruments and improved acoustics for enriched enjoyment of them, and give the artist new materials and techniques for his work. They enrich the humanities in furnishing man with a broader basis for understanding himself, his potentialities, and his place in nature. The historian has a better approach to his subject because of scientific methodology. The archeologist has a surer grasp on temporal relationships because of the tools that physics and chemistry give him for dating materials and identifying their sources. Slowly, an entire world absorbs the increased understanding of man and nature that science generates, and reflects that understanding in its literature, its social, political, and economic institutions, and its application to human daily living. Today, much of the world's population is aware of the world as a body of a solar system in a galaxy among millions of other galaxies. These people can conceive of man in a historical and cosmological perspective that did not exist in centuries past. As this understanding and these concepts spread to more and more of the world's people, it may be hoped that this common bond of understanding will not only give increased motivation to solve peaceably the problems that beset the world, but will also provide increased means for doing so.
