ABSTRACT
Primary hyperparathyroidism is rarely encountered in pregnancy. Because the symptoms may be variable in nature, the diagnosis may be delayed with an increase in maternal and perinatal morbidity or mortality. Several of the symptoms and clinical findings in hyperparathyroidism may also be present with preeclampsia, thus causing difficulty in distinguishing one from the other. Our case report describes a pregnant patient in the third trimester with HELLP syndrome and primary hyperparathyroidism.
Subject(s)
Hyperparathyroidism/diagnosis , Pregnancy Complications/diagnosis , Adult , Female , HELLP Syndrome/diagnosis , Humans , Hyperparathyroidism/therapy , Pregnancy , Pregnancy Complications/therapyABSTRACT
AIDS encephalitis is a common sequela to HIV-1 infection in humans and simian immunodeficiency virus (SIVmac) infection in macaques. Although lentiviral-infected macrophages comprise parenchymal inflammatory infiltrates in affected brain tissue, the mechanisms responsible for leukocyte trafficking to the central nervous system in AIDS are unknown. In this study, we investigated the expression of various endothelial-derived leukocyte adhesion proteins in SIVmac-induced AIDS encephalitis. Encephalitic brains from SIVmac-infected macaques, but not uninflamed brains from other SIVmac-infected animals, were found to express abundant vascular cell adhesion molecule-1 (VCAM-1) protein on the majority of arteriolar, venular, and capillary endothelial cells. Soluble VCAM-1 concentrations in cerebrospinal fluid (CSF) from encephalitic animals were increased approximately 20-fold above those from animals without AIDS encephalitis. Expression of other endothelial-related adhesion molecules, including E-selectin, P-selectin, and intercellular adhesion molecule-1 (ICAM-1), was not uniformly associated with AIDS encephalitis. Thus, the presence of VCAM-1 in both brain and CSF was uniformly associated with SIVmac-induced disease of the central nervous system, and this expression may, at least in part, influence monocyte and lymphocyte recruitment to the central nervous system during the development of AIDS encephalitis. Moreover, measurement of soluble VCAM-1 in CSF may assist in the clinical assessment of animals or people with AIDS.
Subject(s)
AIDS Dementia Complex/etiology , AIDS Dementia Complex/metabolism , Cell Adhesion Molecules/analysis , Simian Acquired Immunodeficiency Syndrome/complications , Simian Immunodeficiency Virus/physiology , Animals , Brain/blood supply , Brain/microbiology , Brain/pathology , Brain Chemistry , Cell Adhesion Molecules/cerebrospinal fluid , Cell Adhesion Molecules/physiology , Endothelium, Vascular/chemistry , Endothelium, Vascular/pathology , Enzyme-Linked Immunosorbent Assay , Ependyma/chemistry , Ependyma/pathology , Immunohistochemistry , Intercellular Adhesion Molecule-1 , Macaca fascicularis , Macaca mulatta , Macaca nemestrina , P-Selectin , Platelet Membrane Glycoproteins/analysis , Simian Immunodeficiency Virus/isolation & purification , Vascular Cell Adhesion Molecule-1ABSTRACT
A synthetic juvenile hormone mimic has been shown to cause premature metamorphosis of the cyprid larva of an acorn barnacle in concentrations as low as 10 parts per billion in filtered seawater. The effect of a juvenile hormone mimic on a crustacean has not previously been demonstrated.
ABSTRACT
Investigation of 33 islands, scattered widely across the Caroline and Marshall Island groups in the Central Pacific revealed no emerged reefs in which corals had unquestionably formed in situ, or other direct evidence of postglacial high stands of sea level. Low unconsolidated rock terraces and ridges of reefflat islands, mostly lying between tide levels, were composed of rubble conglomerates; carbon-14 dating of 11 samples from the conglomerates so far may suggest a former slightly higher sea level (nine samples range between 1890 and 3450 and one approaches 4500 years ago). However, recent hurricanes have produced ridges of comparable height and material, and in the same areas relics from World War II have been found cemented in place. Thus these datings do not in themselves necessarily indicate formerly higher sea levels. Rubble tracts are produced by storms under present conditions without any change in datum, and there seems to be no compelling evidence that they were not so developed during various periods in the past.
