[Comparative study of G8 glycated haemoglobin testing system and the Integra 800 immunoassay]. / Etude comparative du dosage de l'hémoglobine glyquée par la méthode CLHP sur G8 (R) versus Intégra 800 (R).

We compared the results of two methods of measurement of HbA(1c) before replacing the current method on Integra 800 by the HPLC method on an apparatus recently put on the market, the G8. The comparative study of the results for 119 patients was carried out. The reproducibility obtained with the G8 method is good with CV = 0 for the control Level 1 at 5.6%, CV = 0.6% for Level 2 at 10.5% and CV = 0.73% for the Bio-Rad control at 5.7%. The comparison of the results of HbA(1c) gives the Passing - Bablock equation: Y (G8) = X (Integra) + 0.10 with r = 0,996. Systematic bias is of 0.092% and the ratio of the G8/Integra averages of 1.014 (7.43 %/7.34 %). Only 8 results out of the 119 are out of limits of more than 0.4% between the two methods. They are only 4 after bringing together the results by correlation. The two methods provide results with exactitude in conformity with the recommendations of the French governmental agency (Afssaps). The G8 method is slightly better regarding accuracy and precision.