ABSTRACT
BACKGROUND AND AIM: Adiponectin, is an adipose tissue-specific adipokine, that circulates in human plasma at high levels, although lower levels are noted with insulin resistance and atherosclerosis. We investigated the relationship of adiponectin concentrations with dietary factors and some of the cardiovascular risk factors in patients with T2DM. METHODS AND RESULTS: Totally 107 patients with T2DM were recruited from the out patients clinic of Shariati Hospital, Tehran, Iran. Patients were evaluated for laboratory and anthropometric measurements including serum adiponectin, fasting insulin, FPG, OGTT, HbA1c, HOMA-IR, hsCRP, weight, height, BMI and WHR. Nutrients intakes were obtained via 24-h recall from each patient in three successive days. Nutrients and data analysis were done using FPII and SPSS version 13 softwares. The mean of log10-transformed serum adiponectin concentration was 0.79±0.27µg/ml. The univariate linear regression analysis could not show any significant relation between the log of serum adiponectin and dietary factors. In multivariate linear regression after multiple adjustment, the log of serum adiponectin was independently associated with WHR (P=0.02, t=-2.33), HDL-C (P=0.050, t=2.03) and markedly but not significantly with age of patients (P=0.058, t=1.92). CONCLUSIONS: Our findings showed that WHR, one of the important cardiovascular risk factors, can modulate independently adiponectin levels of T2DM patients in inverse manner. Also, the age of patients and HDL-C levels have marked positive effect on circulating levels of this adipocytokine. Thus, adiponectin might be a useful biomarker to prevent developing CVD in type 2 diabetes.
Subject(s)
Adiponectin , Cardiovascular Diseases/blood , Diabetes Mellitus, Type 2/blood , Diabetic Angiopathies/blood , Feeding Behavior , Insulin/blood , Obesity/blood , Adiponectin/blood , Adult , Anthropometry , Biomarkers/blood , Blood Glucose/metabolism , Body Mass Index , Cardiovascular Diseases/epidemiology , Cardiovascular Diseases/prevention & control , Cross-Sectional Studies , Diabetes Mellitus, Type 2/epidemiology , Diabetic Angiopathies/epidemiology , Diabetic Angiopathies/prevention & control , Diet Records , Fasting , Female , Glucose Tolerance Test , Glycated Hemoglobin/metabolism , Humans , Insulin Resistance , Iran/epidemiology , Male , Obesity/epidemiology , Obesity/prevention & control , Risk Factors , Surveys and QuestionnairesABSTRACT
AIM: The discovery of new adipokine, visfatin can significantly enhance our knowledge of insulin resistance and diabetes mellitus. We explored the relation of visfatin concentrations to cardiovascular risk factors, adiponectin and insulin resistance criteria in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Fifty-eight patients with T2DM were recruited from the out patients clinic of Shariati Hospital. Laboratory and anthropometric measurements include FBG, OGTT, HbA1c, fasting serum visfatin, insulin and adiponectin, HOMA-IR and hsCRP, weight, height, BMI and WHR were performed in all participants. All of the statistical data were analyzed using the SPSS15 software. RESULTS: The log(10)-transformed (log) plasma visfatin concentration was in significant positive correlation with age (r=0.286, p=0.033). Patients were divided in two groups by median log visfatin (0.85 ng/mL): group I had low values and group II had high values. In group I the log visfatin was in significant positive correlation with age (r=0.436, p=0.018) and in group II log visfatin was in significant negative correlation with FPG and HbA1c (r>0.4, p<0.05). CONCLUSION: In conclusion high circulating levels of visfatin could be in healthy relations with cardiovascular risk factors, insulin resistance status and adiponectin in diabetic patients.
