ABSTRACT
A cacalolide derivative named 4alpha-[2'-hydroxymethylacryloxy]-1beta-hydroxy-14-(5-->6) abeo eremophilan-12,8-olide and a shikimic acid derivative named (3'E)-(1alpha)-3-hydroxymethyl-4beta,5alpha-dimethoxycyclohex-2-enyloctadec-3'-enoate along with three known compounds, octacosan-1-ol, 3beta-hydroxyolean-12-en-28-oic acid and 3beta-acetoxyolean-12-en-28-oic acid were isolated from Senecio burtonii. Their structures and relative configurations were established on the basis of spectroscopic analysis.
Subject(s)
Naphthalenes/isolation & purification , Senecio/chemistry , Shikimic Acid/analogs & derivatives , Molecular Structure , Naphthalenes/chemistry , Plant Structures/chemistry , Shikimic Acid/chemistry , Shikimic Acid/isolation & purificationABSTRACT
In addition to one known compound, 3beta,8alpha-dihydroxyguaian-4(15),10(14),11(13)-trien-6,12 olide (8-desacylcynaropicrin) (3), two new sesquiterpene lactones have been isolated from the aerial parts of Crepis cameroonica. By means of spectroscopic analysis, the structures and relative configurations of the new compounds were established as 3beta,9beta-dihydroxyguaian-4(15),10(14),11(13)-trien-6,12 olide (1) and 8alpha-hydroxy-4alpha(13),11beta(15)-tetrahydrozaluzanin C (2). The in vitro antimicrobial spectrum of pure compounds and crude extracts are also reported.
Subject(s)
Anti-Bacterial Agents/pharmacology , Crepis , Phytotherapy , Plant Extracts/pharmacology , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/therapeutic use , Gram-Negative Bacteria/drug effects , Gram-Positive Bacteria/drug effects , Humans , Lactones/administration & dosage , Lactones/chemistry , Lactones/pharmacology , Lactones/therapeutic use , Microbial Sensitivity Tests , Plant Components, Aerial , Plant Extracts/administration & dosage , Plant Extracts/chemistry , Plant Extracts/therapeutic use , Sesquiterpenes/administration & dosage , Sesquiterpenes/chemistry , Sesquiterpenes/pharmacology , Sesquiterpenes/therapeutic useABSTRACT
From the methanol extract of the stem bark of Scaphopetalum thonneri, two new compounds, including one lignan, named scaphopetalone, one new ester of ferulic acid, named scaphopetalumate were isolated together with three known compounds including: two coumarins (scopoletin and scopolin), and one pentacyclic triterpene (oleanolic acid). The structure of the new compounds were elucidated by means of spectroscopic analyses.
Subject(s)
Coumaric Acids/isolation & purification , Guaiacol/isolation & purification , Malvaceae/chemistry , Oleanolic Acid/isolation & purification , Tetrahydronaphthalenes/isolation & purification , Triterpenes/isolation & purification , Cameroon , Coumaric Acids/chemistry , Esters , Guaiacol/analogs & derivatives , Guaiacol/chemistry , Lignans , Magnetic Resonance Spectroscopy , Molecular Structure , Oleanolic Acid/analogs & derivatives , Oleanolic Acid/chemistry , Plant Bark/chemistry , Tetrahydronaphthalenes/chemistry , Triterpenes/chemistryABSTRACT
One new diterpenoid, methyl 3alpha-hydroxy-7-oxo-dehydroabietate (1), two new limonoids, 3alpha-deacetyl-amoorastatin (2) and 9beta-amoorastatin (3), and the known limonoid amoorastatin (4) were isolated from the stem of Pterorhachis zenkeri.
